Tip 2 diyabetli bireylerde diyetsel faktörlerin inflamatuvar belirteçler ve serum adiponektin düzeyi üzerindeki etkisi

Abstract

The aim of this study was to determine the effect of dietary factors on serum adiponectin and inflammatory markers in newly diagnosed Type 2 diabetic subjects. This study was conducted with 46 newly diagnosed Type 2 diabetic subjects (case group) and 30 healthy volunteers who determined by the physician (control group), between ages 19-64 years old. In addition to the anthropometric measurements, routine biochemical values (serum total cholesterol, triglyceride, HDL, LDL, VLDL, TSH) and insulin resistance components (fasting blood glucose, HbA1c, fasting insulin, HOMA-IR) were analyzed. Serum CRP, TNF-α, and IL-6 levels were measured to determine the presence of inflammation and serum adiponectin levels were also assessed. Dietary food record was taken for 2 days to assess the nutritional status of the individuals. The values of BMI, fat mass, percentage of fat mass, waist circumference, waist/hip ratio and waist/height ratio were found to be higher in diabetic individuals than controls (p<0.05). However, diabetic subjects had lower levels of HDL cholesterol but TG, VLDL cholesterol levels and insulin resistance values were significantly higher according to the healthy volunteers (p<0.05). It was determined that there was a significant positive correlation between anthropometric measurements and fasting insulin, HOMA-IR, CRP and TNF-α values in male diabetic subjects (p<0.05). In diabetic females, there were a significant positive correlation between waist/hip ratio, and fasting insulin, HOMA-IR (p<0.05). In addition, in the same group, there was a positive correlation between BMI, percentage of fat mass and serum CRP, adiponectin. There was no relationship between adiponectin level and insulin resistance in diabetic subjects (p>0.05). It was found that the dietary GI/GL of individuals were high in both group. There was no significant relationship between the dietary GI/GY and inflammatory markers and insülin resistance components in diabetic group (p>0,05). In this group, the inflammatory markers were positively associated with % carbohydrate of the diet but were negatively associated with dietary fiber (p<0.05). Inflammatory markers and adiponectin levels were not significantly correlated with energy and other macro nutrients. As a result, it is important to determine the presence of inflammation in the body especially in individuals at risk for diabetes. Identification of nutritional and lifestyle factors that affect systemic inflammation may help to determine the oxidative-antioxidant balance and inflammatory state and also reduce morbidity and mortality in diabetic patients. It should be recommended that provide dietary diversity and adequate and balanced nutrition in terms of antioxidant compounds accordance with the physiological conditions of the individual.