Amiyotrofik Lateral Skleroz Hastalarının Deri Biyopsilerinde Epidermal Büyüme Faktörü (Egf) ve Keratinosit Büyüme Faktörünün (Kgf) Ekspresyonunun Değerlendirilmesi

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes immobility. Bed sores are an important problem in immobile patients. However, in ALS, it is known that bed sores are less common than other neurological diseases. A number of studies have been conducted to determine the cause of this, and in our knowledge the effect of epidermal growth factor (EGF) and keratinocyte growth factor (KGF) have not been studied in ALS patients. This study included 10 ALS patients without bed sores and 16 patients with other neurological diseases. Skin biopsies were taken from the skin on the gluteus maximus muscle (proximal region) and 10 cm proximal to the lateral malleolus (distal region). Biopsies were stained with EGF and KGF antibodies by immunohistochemical methods. The samples were evaluated semi-quantitatively. It was observed that EGF expression was higher in the proximal region in ALS patients than in control patients. There was no difference between groups in terms of KGF expression. These results suggest that EGF may be an effective factor in the low incidence of bed injury in ALS patients, similar to other growth factors previously. New studies with a greater number of patients including patients with bed sores are needed to verify our results.