Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
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Recent Submissions
ARTIRILMIŞ GERÇEKLİK DESTEKLİ HAREKETLİ BİLİMSEL İLLÜSTRASYON: HACETTEPE ÜNİVERSİTESİ BİYOSFER MÜZE ÖRNEĞİ
(Güzel Sanatlar Enstitüsü, 2026-03-06) GÜNEŞ Fatma; Grafik
In this thesis, it is aimed to develop an interactive and augmented reality–supported digital exhibition approach that supports traditional exhibition methods by integrating motion graphics into scientific illustration drawings in biodiversity museums. Within the scope of the study, the theoretical foundations, historical development, methods, types, and application areas of scientific illustration were examined; additionally, the interaction possibilities of using two-dimensional motion graphics together with scientific illustration were explored. Considering the dynamic and multilayered nature of biodiversity, particularly in relation to animal species, the contribution of transforming static visuals into dynamic representations through virtual imagery was investigated.
The application project was carried out for the Biosphere Museum within the Hacettepe University Biodiversity Research and Application Center (HUBİOM), and scientific illustrations were prepared for four animals: the Anatolian leopard, brown bear, blue whale, and Tyrannosaurus Rex. In this context, drawings were produced to reflect the skeletal structure, muscular system, and external morphological features (skin, fur) of the animals. The prepared illustrations were supported with augmented reality technology and transformed into experiential content accessible to museum visitors. In addition, audio narrations accompanying the illustrations were provided to offer listening-based learning opportunities for visually impaired individuals. Species-specific behaviors of the selected animals were animated using two-dimensional motion graphics. These animations, which can be viewed and listened to on mobile devices, were enriched with the animals’ natural sounds and environmental atmosphere. The prepared content was designed to be presented to museum visitors via mobile devices.
As a result of the study, it was observed that the combined use of scientific illustration with motion graphics and augmented reality technologies enriches the museum experience, increases visitors’ interaction with exhibition objects, and supports the learning process.
European consensus statement on essential colposcopy
(Tıp Fakültesi, 2021-01) C W E Redman; V Kesic; M E Cruickshank; M Gultekin; X Carcopino; M Castro Sanchez; M Grigore; M Jakobsson; V Kuppers; A Pedro; O Reich; S Leeson; U Tabuica; J Zodzika; A Ciavattini; R Jach; M Katsyuba; R Koiss; P Martin-Hirsch; W A Tjalma; P Nieminen; Kadın Hastalıkları ve Doğum
This European consensus statement on essential colposcopy provides standards for the general colposcopist seeing women referred for colposcopy with an abnormal cervical screening test (including cytology and HPV tests) or with a clinically suspicious cervix. The article gives guidance regarding the aims and conduct of colposcopy. Recommendations are provided on colposcopy technique, the management of common colposcopy issues, treatment and follow-up of after treatment of CIN or early stage cervical. Colposcopists should make an informed decision on the management of each individual that is referred and organize appropriate follow-up. Cervical cancer is still a major health issue and the quality of care can only improve if there is a structured guidance for women with an abnormal smear or suspicious cervix.
Adnexal masses in patients with colorectal cancer
(Tıp Fakültesi, 2021-05) Utku Akgor; Oguzhan Kuru; Burcu Soyak; Ali Can Gunes; Esra Uyanık; Murat Gultekin; Nejat Ozgul; Coskun Salman; Kadın Hastalıkları ve Doğum
Objective: To evaluate the clinicopathological features and outcomes of patients undergone surgery for benign and metastatic adnexal masses during the surveillance of colorectal cancer (CRC).
Methods: A single institute retrospective study involving 90 patients diagnosed with CRC that undergone surgery at Hacettepe University Hospital between 2000-2018. Clinicopathological and survival data was obtained from hospital records.
Results: Elevated blood levels of CEA (HR, 1.23; 95 % CI: 1.03-1.24; p = 0.01), adnexal masses larger than 5 cm (HR, 3.296; 95 % CI: 1.527-7.076; p = 0.002), bilaterality of adnexal mass (HR, 2.200; 95 % CI: 2.464-11.969; p = 0.001) and high PCI score (HR, 0.150; 95 % CI: 0.044-0.479; p = 0.01) were found to be significantly associated with ovarian metastasis. There was a significant difference in overall survival (OS), with respect to complete and incomplete resection in adnexal surgery of ovarian metastasis (46.6 vs. 29.6 months; p = 0.004). The median survival time was 32.8 months for patients with ≤ 24 months interval time to adnexal metastasis surgery, and 48.5 months for patients with >24 months interval time to adnexal metastasis surgery (p = 0.001).
Conclusion: This study showed that numerous clinicopathological variables such as bilaterality and size of adnexal mass, serum blood levels of CEA and PCI score may have a significant impact on the prediction and management of ovarian masses diagnosed during CRC surveillance. Complete resection and interval time to adnexal surgery is significantly associated with OS.
Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy
(Tıp Fakültesi, 2021-05) Utku Akgor; Oguzhan Kuru; Mehmet Sakinci; Gokhan Boyraz; Serhat Sen; Ilker Cakır; Taner Turan; Mehmet Gokcu; Murat Gultekin; Sevil Sayhan; Coskun Salman; Nejat Ozgul; Kadın Hastalıkları ve Doğum
Objective: To investigate the clinicopathologic characteristics, prognostic factors, outcome, and treatment of the neuroendocrine carcinoma (NEC) of the endometrium.
Materials and methods: We retrospectively reviewed the clinicopathologic and survival data of 10 patients who underwent surgery for NEC. The patients were collected between 1999 and 2017 from four referral centers in Turkey.
Results: The median age of patients was 67 years (range: 34-75 years). The NEC of endometrium consist of 9 cases with small cell carcinoma (SC) NEC (two with mixed histotypes), and one with a large cell (LC) NEC. According to FIGO 2009 criteria, 70 % (7/10) of patients had advanced stage (III and IV) disease. All patients except one underwent surgical staging, eight patients received platinum-based chemotherapy (CTX) and of 6 those were additionally treated with radiotherapy (RT). Four patients died of disease ranging from 2 to 10 months and six were alive 12-72 months with no evidence of disease. In addition, 4 SC NEC cases raised in polypoid features had no evidence of disease from 24 to 72 months.
Discussion: NEC of the endometrium is a rare disease with poor prognosis, which frequently diagnosed in advanced stages. The main treatment modality was the administration of platinum-based CTX as an adjuvant to surgery or surgery and RT. Our result suggests that the polypoid feature of the tumor might be one of the best predictors for the prognosis of SC NEC.
Results of the interprofessional and interdisciplinary Berlin round table on patient-reported outcomes, quality of life, and treatment expectations of patients with gynecological cancer under maintenance treatment
(Tıp Fakültesi, 2020-10-30) Robert Armbrust; Sara Alavi; Adak Pirmorady; Frank Chen; Nicoletta Colombo; Murat Gultekin; Charo Hierro; Birthe Lemley; Mansoor Raza Mirza; Esra Urkmez; Christina Fotopoulou; Jutta Vinzent; Antonio Gonzalez Martin; Andrea Krull; Judith Heepe; Mathias Rose; Jalid Sehouli; Kadın Hastalıkları ve Doğum
Background: Patients' reported outcomes and their perspectives around their therapeutic management is a field of continuously increasing relevance in gynecological oncology. We report the results of the Berlin dialog on seven patient-reported parameters and outcomes concerning chemotherapy and maintenance treatment in patients with gynecological cancer.
Methods: Key opinion leaders in gynecological oncology from different European counties and representatives of leading patients' advocate groups in Berlin held a consensus meeting in Berlin on April 6, 2019. Seven topics of interest were identified in advance around quality of life, iatrogenic toxicity, treatment decision-making processes, sexuality, participation in clinical trials, second opinion, and long-term survivors with the the following standard operating procedure for processing and discussion: (1) agreement on its relevance; (2) literature review, and (3) discussion and consensus statements.
Results: All main topics reached a consensus approval. The defined statements emphasized the importance of patients' role in incorporating and establishing quality of life as an outcome parameter in clinical trials. Furthermore, discussants raised the importance of identifying new tools for reflecting patient-reported iatrogenic toxicity as well as emphasizing patients' rights in providing personal information, access to second opinion in the decision-making process, and their participation in clinical trials.
Conclusion: The results of this round table meeting could help redefine perspectives on the discussed topics and the importance for therapeutic management as well as for trial designs.