Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
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İyot Eksikliği Bölgesinde Radyografik İşlemler Sırasında İyotlu Kontrast Uygulanması Sonrası Gelişen Hipertiroidizm Sıklığı ve Etkileyen Faktörler
(Tıp Fakültesi, 2025-07-25) Ece Karaca Köle; İç Hastalıkları
The aim of this study is to evaluate the incidence and determinants of thyroid dysfunction following iodinated contrast media (ICM) exposure in a population residing in an iodine-deficient region, consisting of middle-to-older-aged individuals with high cardiovascular risk. Specifically, it aims to identify risk factors for the development of hyperthyroidism and to develop a clinically applicable risk score.Thyroid function was assessed in a total population of 385 patients, including a retrospective cohort (n=265) and a prospective cohort (n=120), who were scheduled for contrast-enhanced imaging or interventional procedures during cardiology evaluations. Baseline thyroid function tests, thyroid ultrasonography, and clinical parameters were analyzed for all patients. Risk factors associated with the development of hyperthyroidism were identified using multivariable analysis, and a nomogram-based risk score was developed. The overall incidence of hyperthyroidism following ICM exposure was found to be 12.7% (overt: 8.3%; subclinical: 4.4%). Patients who developed hyperthyroidism were older (65.8±8.7 years versus 60.5±8.7 years, p<0.001), had lower body weight (74.0±12.8 kg versus 79.8±14.5 kg, p=0.008), and larger thyroid volume (21.70 [15.90–27.55] mL versus 14.70 [11.90–19.20] mL, p<0.001). They also exhibited lower baseline TSH levels (0.77 mIU/L versus 1.72 mIU/L, p<0.001) and higher sT4 levels (13.87±3.96 pmol/L versus 11.87±2.68 pmol/L, p=0.005). The presence of nodular goiter and a family history of thyroid disease emerged as significant risk factors. Variables found significant in univariate analyses were included in a multivariate logistic regression model. Independent predictors of hyperthyroidism development were: low pre-contrast TSH (p=0.001, OR=15.254), elevated sT4 (p=0.031, OR=6.638), increased thyroid volume (p=0.009, OR=5.954), lower BMI (p=0.044, OR=3.863), and older age (p=0.028, OR=4.038). A risk score was developed based on these variables. This scoring model enables individualized risk prediction prior to contrast administration by integrating these parameters. Although 76.7% of hyperthyroid cases resolved within six months, persistent hyperthyroidism was observed in 23.3% of patients, and recurrence occurred in 18.2%.
In conclusion, thyroid dysfunction is frequently observed following ICM exposure in iodine-deficient populations. This study highlights the importance of identifying high-risk individuals in advance and taking appropriate preventive measures. The risk score developed in this study may serve as a practical predictive tool in clinical settings.
Depremde İmal Edilmiş Riskler Karşısında Bireylerin Mücadele Kapasitesinin Anlaşılmasına Yönelik Bir Derin Öğrenme Modeli Denemesi
(Sosyal Bilimler Enstitüsü, 2026) Coşkun, Serkan; Sosyoloji
This thesis examines the “manufactured risk regime” revealed by the 6 February 2023 Kahramanmaraş earthquakes, particularly in Hatay, through the disaster coping capacity of individuals and households. Bringing together Beck’s risk society, Giddens’s reflexive modernity and neoliberal responsibilization debates, Bourdieu’s capital approach, and the ecological/community resilience literature, it develops an original 5+1 Capital Model comprising economic, social (bonding–bridging–linking), cultural, human, physical, and social-ecosystem dimensions. This model is used to conceptualize and measure coping capacity along the tension between “the naturalness of hazard and the sociality of vulnerability.”
Within an explanatory sequential mixed-methods design, a survey was administered to 458 households across 15 districts of Hatay. The 5+1 capital indicators were psychometrically tested through EFA/CFA and integrated into a structured resilience index using MIMIC and causal-chain SEM models. Subsequently, XGBoost, Random Forest, Artificial Neural Networks, and Decision Trees were employed to model multidimensionally resilience scores; SHAP and GAM analyses were used to uncover threshold, saturation, and regime effects of capital blocks, as well as their interactions with demographic variables. Latent Profile Analysis and K-Means clustering identified four core resilience profiles, while in-depth and focus group interviews combined with Gephi-based network analysis made the quantitative patterns visible in everyday practices.
The findings show that economic capital, the public service ecosystem, housing resilience, and bonding social capital constitute the core layers of coping capacity, whereas cultural and human capital, together with bridging/linking ties, play complementary and reinforcing roles. The study thus offers a theoretically integrated capital model and an empirical basis for targeted policy recommendations tailored to different resilience profiles.
Refah Devletinden Düzenleyici Devlete: Bağımsız Düzenleyici Kurumlar ve Enerji Piyasası Düzenleme Kurumu
(Sosyal Bilimler Enstitüsü, 2026) Ünal, Ali Haydar; Kamu Hukuku
Independent regulatory agencies proliferated globally during the final quarter of the twentieth century, engendering a profound transformation in the organizational form and functional orientation of the state. Although such agencies have existed in the United States since the nineteenth century, their worldwide diffusion is closely intertwined with the ascendancy of neoliberal accumulation. Promoted by international organizations such as the IMF, the World Bank, and the OECD, these bodies are situated within the conceptual framework of the regulatory state that emerged under the Post-Washington Consensus, and they embody a form intrinsically linked to the intensified globalization of capital in the neoliberal era. The crisis of neoliberalism in 2008, alongside recent political developments most notably Donald Trump’s return to power in the United States and his subsequent escalation of tariff barriers has likewise begun to reshape the trajectory and future prospects of regulatory agencies in conjunction with broader transformations in the globalization process. This study concentrates on the transformation engendered by independent regulatory agencies in the form of the state, and specifically in the modalities of state intervention that structure economic regulation. To elucidate this transformation, the welfare state is examined as a point of historical contrast, with the aim of demonstrating the divergence between the economic interventions characteristic of the welfare-state era and those associated with the regulatory state under neoliberalism. Accordingly, the study first analyzes the welfare state through the lens of the Regulation Approach within the context of Fordism, followed by an explication of the crisis of Fordism and the emergence of neoliberal accumulation. It then investigates the evolution of regulatory agencies within the neoliberal accumulation regime. Finally, the analysis turns to independent regulatory agencies in Turkey, with particular emphasis on the Energy Market Regulatory Authority within the electricity sector. By examining the crisis of neoliberalism and the consequent transformation of independent regulatory agencies in Turkey, the study brings its inquiry to a conclusion.
Effort in Machine Translation Post-Editing: The Role of Translation Expertise and Individual Cognitive Differences
(Sosyal Bilimler Enstitüsü, 2026) Sayar Öztürk, Minel; Mütercim-Tercümanlık
Machine translation post-editing (MTPE) has become an integral component of contemporary translation workflows. While technological advances are often assumed to reduce human effort, research suggests that effort in MTPE is complex and multidimensional. This dissertation investigates the relationship between expertise, effort, accuracy, and individual cognitive differences in MTPE, addressing three research questions: (1) to what extent expertise serves as a valid indicator of cognitive, temporal, and technical/linguistic effort in MTPE; (2) how expertise relates to objective and self-reported effort and post-editing (PE) accuracy; and (3) whether individual cognitive difference scores predict effort during MTPE. A mixed-methods experimental design was employed with 21 participants grouped as experienced translators, inexperienced translators, and field experts. Participants post-edited three legal texts that had been machine-translated from English into Turkish. Data were collected through keylogging using Translog-II, capturing total task duration, mean pause duration, total pause duration, pause percentage, pauses per word, text production and elimination, and user and production events per minute indicators. PE accuracy, post-task questionnaires, and retrospective think-aloud protocols were also collected. Additionally, individual cognitive differences were examined using executive function tests administered in the PEBL, measuring cognitive flexibility, inhibition, and working memory. The findings demonstrate that experienced translators often invested more temporal, cognitive, and technical/linguistic effort than the other groups, reflecting deliberate monitoring, revision, and quality control strategies. At the same time, expertise emerged as the strongest predictor of PE accuracy. Cognitive flexibility was found to meaningfully predict how effort was managed during MTPE, while inhibition and working memory showed more limited and selective effects. Consequently, the results indicate that effort in MTPE is shaped by expertise and cognitive profiles rather than being automatically reduced by technology, underscoring the continued centrality of expert human translators in achieving high-quality PE outcomes.
UNDERSTANDING MIDDLE POWERS’ REGIONAL INITIATIVES A COMPARISON OF TÜRKIYE’S ASIA ANEW AND THE REPUBLIC OF KOREA’S NEW NORTHERN POLICY
(Sosyal Bilimler Enstitüsü, 2026-01-29) Hanryung Lee; Uluslararası İlişkiler
This thesis examines how structurally similar two middle powers: Türkiye and South Korea came with distinct regional initiatives under the same international conditions. Since the end of the Cold War, changing global structure created greater room for autonomy and heightened uncertainty. Middle powers became more active in the fields of global governance, norms and regional projects. Yet the concept of middle power still remains ambiguous allowing governments and other actors to set in terms of identity, history, domestic debates and capabilities for regional/global roles. Türkiye and South Korea are representative cases: both are located within great powers—geographically and ideologically, historically depended on the United States for security and sought greater autonomy in the post Cold War era. Despite similar backgrounds, the initiatives they produced took different forms. Türkiye’s Asia Anew Initiative launched in 2019 reflected their civilisational identity, strategic depth and Eurasian positioning; while South Korea’s New Northern Policy announced in 2017 grew from constrained autonomy, a new cabinet after impeachment, economic diversification and middle power diplomacy. The thesis asks why two middle powers developed region-specific initiatives at similar times but through different conceptualisations, tools and domestic pathways. The study argues that structural incentives alone cannot explain the variation. Middle powers do not automatically update their policies when conditions change; windows of opportunity must meet domestic actors who would diagnose problems, propose alternatives and mobilise resources. Using a four cue framework distinguishing idea and policy entrepreneurship, the thesis shows how identity framing, institutional channels, and interpretations of constraints produced different outcomes. The findings contribute to understanding how entrepreneurial agency interacts with domestic structures in shaping regional policies and what this suggests for the study of middle powers and regional cooperation.