Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Communities in DSpace
Select a community to browse its collections.
- Ankara State Conservatory
- Directorates
- Faculty of Dentistry
- Faculty of Pharmacy
- Faculty of Letters
Recent Submissions
Treadmill versus overground gait training in patients with lower limb burn injury: A matched control study
(2022) Özkal, Özden; Kısmet, Kemal; Konan, Ali; Hayran Kadir, Mutlu; Topuz, Semra; Genel Cerrahi
Introduction: Gaitimpairmentis commonlyseeninpatientswith alower limb burninjury(LLBI).
Therefore, the aim of this study was to investigate the effects of two different gait training
modes on gait symmetry, functional mobility and kinesiophobia in patients with LLBI.
Methods: This matched control study was conducted between January 2017 and August 2018.
Patients with LLBI (n=28) were allocated to 2 different groups by matching according to burn
localization, age, and gender. Group 1 (overground group: n=14) received overground gait
training in addition to standard burn rehabilitation, and Group 2 (treadmill group: n=14)
received treadmill gait training in addition to standard burn rehabilitation. The rehabilitation
program and gait training were started when the patient was admitted to the hospital and
ended on discharge. These physical therapy interventions were performed 5 days per week.
The gait training intensity, including walking speed and duration, was determined according
topatienttolerance. Gaitparameters,functionalmobility, kinesiophobia andpainvalues were
evaluated with GAITRite, the timed up-and-go test (TUG), Tampa Kinesiophobia Scale and
Visual Analogue Scale, respectively. These evaluations were made twice; on admission and
immediately prior to discharge. Gait symmetry was calculated using the Symmetry Index.
Results: The baseline characteristics ofthe groups and initial outcome values were similar. In
the comparison ofthe differences between the overground and treadmill groups,the change
in kinesiophobia and TUG values were significantly higher in the treadmill group (p=0.01,
p=0.02, respectively). The intragroup comparisons showed significant differences in SI in
respect of step length (p=0.004), swing (p=0.006), stance (p=0.008) and velocity (p=0.001),
cadence (p=0.001), TUG (p=0.001), kinesiophobia (p=0.001) and pain (p=0.001) in the
overground group. Statistically significant differences were determined in step length
(p=0.01), swing (p=0.01), stance (p=0.02) and velocity (p=0.001), cadence (p=0.001), TUG
(p=0.001), kinesiophobia (p=0.001) and pain (p=0.001) in the treadmill group, when pre and
post-training values were compared.
Conclusions: The results of this study have shown that treadmill gait training was more
effective in the improvement of functional mobility and reduction in kinesiophobia levels of
patients with LLBI compared to overground gaittraining. Both overground and treadmill gait
training also provide greater improvements in the velocity and cadence, and gait symmetry
for step length, swing and stance in patients with LLBI.
Clinical predictors of pulmonary functions, respiratory/peripheral muscle strength and exercise capacity at discharge in adults with burn injury
(2021) Özkal, Özden; Topuz, Semra; Karahan, Sevilay; Erdem, Melek Merve; Konan, Ali; Yastıh, Ahmet Çınar; Genel Cerrahi
Purpose: To identify clinical predictors of pulmonary functions, respiratory and peripheral muscle strength and functional exercise capacity in burn injury patients, and to compare these parameters with healthy subjects.
Methods: The study included 47 burn injury patients aged 20-49 years, and 47 age and gender-matched healthy subjects. The patients were evaluated on the day of discharge from hospital. Pulmonary functions and respiratory muscle strength were assessed with a spirometer (Cosmed Pony FX). Hand grip and pain were evaluated with a Jamar dynamometer and visual analog scale, respectively. The six-minute walk test (6-MWT) was performed to determine the functional exercise capacity of the participants.
Results: With the exception of FEV1/FVC, all the parameters of pulmonary functions test, respiratory and peripheral muscle strength and 6-MWT distances were lower in the burn injury patients than in the healthy subjects (p < 0.05). Significant predictors for these parameters were age, gender, height, body mass index, total burn surface area, burn injury type, the presence of trunk burn, hand burn, lower limb burn, inhalation injury, and intubation in the burn group (p < 0.05).
Conclusions: Burn injury and the demographic characteristics of the patients are important determinants of clinical parameters. These results are clinically important as they can be of guidance in creating a personalized rehabilitation program.
Clinical trial registration number: NCT03780218.Implications for rehabilitationBurn patients have impaired pulmonary functions and exercise capacity at discharge. Assessment of respiratory muscle strength should be added into clinical practice in adults with burn injury.Lung functions and exercise capacity should be evaluated in burn patients at discharge.It is important to monitor lung functions of burn patients after discharge.
A Learning-Based Fault Detection Approach for Unmanned Aerial Systems Using Inertial Sensor Data
(Fen Bilimleri Enstitüsü, 2026) Furkan YÜKSEL; Bilgisayar Mühendisliği
This thesis presents a lightweight embedded fault detection framework for identifying propulsion system faults in Unmanned Aerial Vehicles (UAVs) using inertial sensor measurements. Mechanical degradation, imbalance, and physical damage affecting motors and propellers may reduce flight performance and compromise operational safety. Consequently, there is an increasing need for fault detection methods capable of operating in real time on resource-constrained embedded platforms.
The proposed approach utilizes three-axis acceleration and angular velocity measurements acquired from an onboard Inertial Measurement Unit. First, the raw sensor measurements undergo a lightweight preprocessing stage and are transformed into the frequency domain using the Fast Fourier Transform. Dominant frequencies, spectral amplitudes, band energies, and harmonic ratios are then extracted from the resulting spectrum to construct a compact feature vector.
To eliminate the need for labeled datasets, an online clustering algorithm is proposed for fault detection. The algorithm incrementally learns the characteristics of normal operating conditions and continuously evaluates newly acquired observations against the learned model. As a result, abnormal behavior can be identified without requiring an offline training stage while preserving the ability to adapt to changing operating conditions.
The proposed framework is experimentally evaluated under healthy, broken propeller, bent propeller, and direction-incompatible propeller scenarios. The results demonstrate that the method can successfully identify several abnormal operating conditions. Furthermore, power consumption, execution time, and memory analyses show that the proposed framework can operate in real time on resource-constrained embedded hardware.
Kedi Alerjenlerinin Hava Yolu Yeniden Yapılanmasına ve Oksidatif Stres Üzerine Etkisi
(Fen Bilimleri Enstitüsü, 2026) Çağla Burçin Bıçakçı; Biyoloji
In respiratory diseases, whose global prevalence is steadily increasing, exposure to allergens significantly affects the onset and severity of the disease. Airway epithelial cells, which constitute the primary barrier against inhaled allergens, protect the airways from external agents through their chemical and immune functions, as well as their physical barrier role. Airway allergens can be broadly classified as indoor and outdoor allergens. Among indoor allergens, cat allergens are among the most frequently encountered. Although there are studies in the literature demonstrating the disruptive effects of cat allergens on the epithelial barrier structure, research highlighting their impacts on oxidative stress and airway remodeling, both of which hold a pivotal role in the pathology of respiratory diseases, remains limited and insufficient.
This thesis aims to investigate the effects of Fel d 1 and Cat Dander Extract (CDE) allergens on processes associated with airway remodeling and oxidative stress. In this context, a co-culture system comprising bronchial epithelial cells (16HBE14o-) and fibroblast cells (CCD-16Lu) was established to mimic the airway microenvironment. To evaluate airway remodeling, the protein expressions of α-SMA, Vimentin, and Collagen I in CCD-16Lu cells were analyzed via Western Blotting, while their gene expression levels were examined using Real-Time Polymerase Chain Reaction (qPCR). The levels of Matrix Metalloproteinases (MMP-2, MMP-9) and their tissue inhibitors (TIMP-1, TIMP-2) were measured by Enzyme-Linked Immunosorbent Assay (ELISA), and their corresponding gene expressions were determined in CCD-16Lu cells. Oxidative stress parameters were evaluated using 16HBE14o- cells. The gene expressions of HMOX1, NOX4, TXNRD1, and GPX4, which are associated with oxidative stress and antioxidant activity, were analyzed by Real-Time PCR, and total intracellular ROS levels were determined through ROS assays.
Following the experiments and data analyses, a dose-dependent increase in the gene and protein expressions of α-SMA and Collagen I, key markers associated with airway remodeling, was detected upon stimulation with both allergens. ELISA results revealed an alteration in the MMP/TIMP balance, indicating that allergen-stimulated cells failed to tolerate the accumulation of proteins such as collagen. The dose- and allergen-dependent increases observed in TIMP-1 and TIMP-2 levels suggest a cellular response activated to counteract the tissue damage induced by the allergens.
Overall, the findings of this thesis demonstrate that airway remodeling and oxidative stress, which play crucial roles in respiratory diseases such as asthma, are significantly affected by cat allergens, and the underlying mechanisms vary depending on the specific allergen stimulation.
FARKLI TARIM YÖNTEMLERİ VE HASAT ZAMANININ DOMATESLERİN ANTİOKSİDAN BİLEŞİKLERİ VE ANTİOKSİDAN AKTİVİTESİ ÜZERİNE ETKİSİ
(2026) AYLİN İŞLER; Beslenme Bilimleri
Tomato (Solanum lycopersicum) is an important fruit in human nutrition due to its rich content of bioactive compounds with antioxidant properties, including lycopene, β-carotene, ascorbic acid, and phenolic compounds. The antioxidant activity of tomatoes may be influenced by several factors such as genotype, environmental conditions, harvest time, and cultivation practices. This study aimed to compare the antioxidant activities of tomatoes cultivated under organic (Afyon-Başmakçı), conventional (Denizli-Sarayköy), and soilless (Afyon-Sandıklı) agricultural production systems, with samples collected in June and August. The samples were freeze-dried and extracted with 80% ethanol, and their antioxidant activities were evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Antioxidant activity was determined by calculating the half-maximal inhibitory concentration (IC₅₀) values of the extracts. The IC₅₀ values of the tomato samples ranged between 97.93 and 947.10 µg/mL. Among the samples
harvested in June, the highest antioxidant activity was observed in the soilless-grown tomato (H.T.: 423.54 µg/mL), followed by conventional (H.K.: 486.15 µg/mL) and organic (H.O.: 670.18 µg/mL) samples. Among the samples harvested in August, the
highest antioxidant activity was observed in the conventional sample (A.K.: 97.93 µg/mL), followed by organic (A.O.: 898.15 µg/mL) and soilless-grown (A.T.: 947.10 µg/mL) samples. When compared across harvest periods, antioxidant activity increased in the conventional sample from June to August, whereas it decreased markedly in both organic and soilless-grown samples. These findings demonstrated that antioxidant activity varied considerably not only by cultivation method but also by harvest time. In conclusion, the antioxidant activity of tomatoes appears to be influenced not only by cultivation method but also by factors such as harvest time, environmental conditions, and genotype. Therefore, the evaluation of different agricultural production systems should consider all factors affecting nutritional quality rather than cultivation method alone.