Biyomühendislik: Recent submissions
Now showing items 21-40 of 64
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Havayolu Modellemesi Amaçlı Tasarlanan Mühendislik Ürünü 3B Hücre Kültür Sistemlerinin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2022-06)Chronic airway diseases have a complex set of mechanisms in which environmental and genetic factors play a role. It is very important to study the molecular pathologies of these diseases and to establish suitable cellular ... -
Kemik Tümörlerinde Lipozomal Kannabinoidlerin Reseptör Aracılı Antiproliferatif ve Apoptotik Etkilerinin Araştırılması
(Fen Bilimleri Enstitüsü, 2022-12-30)Primary osteosarcoma is the most common osteogenic tumor in children and adolescents, known with its rapid metastasis. The limitations of the treatment approaches applied in the clinic and the side effects observed in ... -
Böbrek Transplantasyonu Yapılacak PRA (Panel Reaktif Antikor) Pozitif Hastalarda Hla Haplotipleri İle İmmünofenotip İlişkisinin Araştırılması
(Fen Bilimleri Enstitüsü, 2022)The Human Leukocyte Antigen (HLA- Human Leucocyte Antigen) has an extremely complex morphology. This complex structure is an important factor that causes incompatibility between the patient and the donor, especially when ... -
Yüzey Plazmon Rezonans Sensörü ile Sentetik Reseptörler Kullanılarak Sütte Bulunan Benzilpenisilinin Tayini
(Fen Bilimleri Enstitüsü, 2022)Antibiotic residues in food products, drinking water and the environment cause the emergence of antibiotic-resistant bacterial strains, disruption of the normal ecological balance, and serious health consequences, including ... -
Kurkumin Tayinine Yönelik Yüzey Plazmon Rezonans Temelli Nanosensörlerin Hazırlanması
(Fen Bilimleri Enstitüsü, 2021-12)Herbal ingredients are among the most used products in alternative and complementary medicine. Curcumin, which is obtained from Curcuma longa plant known as Indian saffron or turmeric, has become quite popular in recent ... -
Centella Asıatıca Bitki Özütü ile Kaplı Gümüş Nanopartikül İçeren Polimer Liflerin Yara İyileştirici Etkisinin in Vitro ve in Vivo Araştırılması
(Fen Bilimleri Enstitüsü, 2021)In this study, we synthesized functional silver nanoparticles (AgNPs) from silver ions using the therapeutic plant extract of Centella asiatica (CA). The formation of AgNPs coated with CA functional groups (CA-AgNPs) is ... -
Deselülerize Miyokard-Elastomer Yamaların Hazırlanması ve In Vitro Performanslarının İncelenmesi
(Fen Bilimleri Enstitüsü, 2021)Heart failure is the final stage of most cardiovascular diseases, such as myocardial infarction. Unlike other tissues such as bone and skin, heart tissue does not have the ability to regenerate and repair itself. This ... -
Adenozin Tayinine Yönelik Optik Temelli Nanosensörlerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2022-01)In this thesis, a novel measurement method is proposed to measure the level of adenosine nucleoside which is a significant molecule utilized as a direct or indirect indicator to detect diseases such as neurodegenerative ... -
Aptamer Temelli Afinite Kromatografisiyle Protein C Saflaştırılmasının Araştırılması
(Fen Bilimleri Enstitüsü, 2021-12-30)Protein C (PC) is a vitamin K-dependent plasma protein. Activated Protein C (APC) is a glycoprotein derived from protein C. It is formed by cleavage of an activation peptide by the thrombin-linked thrombomodulin (T-TM) ... -
Nanotopografik Fiber Matrikslerin Doku İskelesi Olarak Üretimi ve İn-Vitro Etkinliklerinin İncelenmesi
(Fen Bilimleri Enstitüsü, 2022)This study was funded by Hacettepe University Scientific Research Projects Coordination Unit (BAP) graduate project entitled "Production Of Nanotopographic Fiber Matrices As Tissue Scaffold And Investigation Of Their ... -
Spermatogenezin Tasarlanmış Farklı Üç Boyutlu Fare Epididimal Beyaz Yağ Dokusu - Testis Kokültüründe Değerlendirilmesi
(Fen Bilimleri Enstitüsü, 2022)Gonadotoxic treatments in childhood cancer patients damage the testicular germ cells and microenvironment, causing 46% of the patients to become infertile. Air-liquid interphase (ALI) and U-plate (UP) techniques are ... -
Konkanavalin A Baskılanmış Yüzey Plazmon Rezonans Temelli Biyosensörün Hazırlanması
(Fen Bilimleri Enstitüsü, 2022)Within the scope of this thesis, a Concanavalin A imprinted surface plasmon resonance (SPR) biosensor was prepared for the determination of Concanavalin A. At the beginning, the surface of the SPR biosensor chip was modified ... -
Gıda Örneklerindeki Benzil Penisilin Hassas Tayinine Yönelik Moleküler Baskılanmış Polimer Temelli Optik Sensörlerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021)Penicillin is one of the most commonly used beta antibiotics and has long been widely used in the treatment of various bacterial infections in humans, livestock, poultry and aquaculture. Therefore, the detection of these ... -
Pamuklu Kumaş Üzerinde Yıkanmış Kan Lekesinin Raman Spektroskopi ve Kemometri ile Tespiti
(Fen Bilimleri Enstitüsü, 2022)Bloodstains are abundant biological fluids that are encountered in crime scenes. Precise bloodstain detection on the “proof” has vitally importance for ongoing or post-commital stages. The criminal inclined to dispose the ... -
Poli(3-hidroksi bütirat)/Poli(bütilen adipat-ko-tereftalat)/İpek- Bazlı Tendon Doku İskeleleri: Karakterizasyon ve Tenojenik Aktivite
(Fen Bilimleri Enstitüsü, 2022-02)Tendon ruptures are frequently seen in tendons due to inflammation and lesions caused by factors such as mechanical stress accumulation, aging, genetic predisposition, and trauma. Tendon tissue engineering approaches are ... -
Tetrasiklin Tayinine Yönelik Aptamer Bağlı Peroksidaz Benzeri Mikropartiküllerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021)Sensitive and selective methods are needed for the determination of antibiotic residues accumulated in food and water sources to protect human safety and health. Traditional methods used for determination of tetracycline ... -
İlaç Araştırmaları İçin 3-Boyutlu Mikroakışkan Damar Modelinin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021)There is a need for a 3-dimensional (3D) vessel model that can be used to simulate in vivo vessel physiology, anatomy, and blood flow-induced fluid tension force that can be used in the investigation of vascular diseases, ... -
Hücresizleştirilmiş Sığır Gözü Kası ve Pclkas Matriksi Kompozit Doku İskeleleriyle Göz Kası Rejenerasyonu
(Fen Bilimleri Enstitüsü, 2021)This study has been financially supported by TÜBİTAK under the project named "Extraocular Muscle Regeneration by Decellurized Bovine Extraocular Muscle and PCL-Extraocular Muscle Matrix Composite Tissue Skeleton" (1002 ... -
Akciğer Havayolu Modellemesine Yönelik Oluşturulan Deselülerize Doku İskeleleri ile 3b Hücre Kültür Sistemlerinin Kurulması
(Fen Bilimleri Enstitüsü, 2021)The lungs have the task of providing the necessary oxygen for the cells and carrying out the carbon dioxide formed as a result of metabolic events. During this process, which we call breathing, the lungs encounter many ... -
MOLEKÜLER BASKILANMIŞ KRİYOJEL DİSKLERDEN KURKUMİNİN KONTROLLÜ SALIMI
(Fen Bilimleri Enstitüsü, 2021-07)In the drug research area, the way these drugs are administered to patients is as important as developing new molecules for the treatment of diseases. In recent years, controlled drug release systems have been developed ...