Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
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Recent Submissions
Effect of the Shelving Technique on the Outcome of Embolization in Intracranial Bifurcation Aneurysms
(2022) Arat, A.; Cay, F.; Radyoloji
Abstract
Background and purpose: Stent bulging technique has been introduced as a technique that improves the outcome of aneurysm coiling. Our aim was to evaluate the utility of this technique, which involves the intentional herniation of stents into the bifurcation aneurysms during coiling.
Materials and methods: Unruptured bifurcation aneurysms treated by stent-assisted coiling using a single type of low-profile braided (LEO Baby) stent between November 2012 and October 2018 were retrospectively evaluated. The clinical (age and sex) and morphologic characteristics (aneurysm size, neck size, proximal/distal diameters of the stented artery, incorporation of the origins of the side branches to the aneurysm neck, and bifurcation angle) and response to antiplatelet therapy were evaluated.
Results: Sixty-one patients (29 men, 47.5%; mean age, 55.95 [SD, 12.33] years) with 66 aneurysms were included. There were 36 aneurysms in group A (treated with the stent bulging technique) and 30 aneurysms in group B (treated by classic stent-assisted coiling). There was no significant difference in the patient and aneurysm characteristics in the groups except for the larger size and wider neck of the aneurysms in group A (P = .02 and P = .04, respectively). At the mean follow-up of 27.30 (SD, 17.45) months, there was no significant difference in the complication rate, the occlusion status, and the early and long-term occlusion rates between the groups. The stent bulging technique did not predict total occlusion (Raymond-Roy I) at the final imaging follow-up.
Conclusions: The stent bulging technique enables the coiling of larger, wide-neck aneurysms; however, we did not observe an added flow-diversion effect with the stent bulging technique compared with conventional stent-assisted coiling. We, therefore, suggest that bifurcation aneurysms should be coiled as densely and as safely as possible using this technique.
Pan-Immune Inflammation Value as a Novel Comprehensive Predictor of In-Hospital Mortality in Patients with Severe Burns: A Single-Center Retrospective Analysis
(2025) Dinçer, Hilmi Anil; Koci, Sara; Cennet, Ömer; Konan, Ali; Genel Cerrahi
Background and Objectives: Despite the advances in the treatment, severe burns with total
burn surface area ≥ 20% are still a major cause of mortality worldwide. Pan-immune
inflammation value (PIV) is a novel and promising biomarker to predict prognosis and
mortality in various diseases. The aim of this study was to evaluate the utility of PIV
to predict in-hospital mortality of patients with severe burn. Materials and Methods: This
retrospective cross-sectional study included ≥18 years old patients with severe burn who
were admitted to hospital within 12–24 h after the burn injury between January 2007
and August 2024. The demographics, clinical and laboratory characteristics of patients
were recorded from electronic hospital records. Pan-immune inflammation value was
calculated as neutrophil counts x monocyte count x platelet counts divided by lymphocyte
counts. The receiver operating characteristic (ROC) analysis was conducted to determine
the predictive value of PIV for mortality. Results: A total of 100 patients (median age
41 (26.3–55) years; 79% male) were included in the study of whom 23 were non-survivors.
The PIV was significantly higher in non-survivors when compared to survivors (p = 0.009).
The ideal cut-off of PIV was 1185, with a sensitivity of 69.6% and a specificity of 66.2%.
The multivariate analysis showed that high PIV along with inhalation injury, and the need
for surgery were predictors of in-hospital mortality. Conclusions: This study is the first to
demonstrate that the novel, comprehensive index, PIV, is a reliable immuno-inflammatory
marker predicting in-hospital mortality in patients with severe burn.
Silver Sulfadiazine and Boric Acid are Effective in Protecting the Stasis Zone from Secondary Ischemia
(2025) Süer, Muhammed Salih ; Cennet, Ömer; Ülkir, Mehmet; Zirh, Elham Bahador; Fırat, Ayşegül; Konan, Ali; Genel Cerrahi
A burn wound is characterized by hyperemia on the outer layer, stasis in the middle zone, and coagulation zones in the innermost region due to thermal damage to the skin. It is crucial to provide prompt and adequate treatment to prevent further damage. The depth of the burn increases as ischemic indicators become more distinct in the stasis zone when the burn is not adequately treated, despite the absence of ischemic signs in the stasis zone at the initial stages of the wound.
This study aims to assess the impact of silver sulfadiazine, boric acid, low-molecular-weight heparin, and glyceryl trinitrate on wound healing in the stasis zone. The study involved 4 intervention groups, each consisting of 6 rats, and a sham group. After 7 days of daily topical application of the active substances, the animals were sacrificed, and wound healing in the stasis zones was evaluated through macroscopic, histological, and immunohistochemical analysis. These findings demonstrate the effectiveness of these treatments in promoting wound healing.
The results demonstrated that the boric acid and silver sulfadiazine groups exhibited the highest levels of wound healing, both macroscopically and histologically. Immunohistochemistry revealed significant differences, with the silver sulfadiazine group demonstrating superior results in MMP9 staining and the boric acid group in VEGF staining (P < .05). These findings suggest that boric acid and silver sulfadiazine effectively prevent ischemia in the stasis zone. Boric acid, in particular, appears to have significant potential as a wound-healing agent due to its anti-inflammatory properties.
Kortikal Yayılan Depolarizasyonun cGAS-STING Yolağı Üzerindeki Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2026-06-09) Soylu Kadir Oğuzhan; Nörolojik ve Psikiyatrik Temel Bilimler
Cortical spreading depolarization (CSD) is a slowly spreading neuronal and glial depolarization wave through the cortex. CSD plays roles in ischemic and traumatic brain injury and it is thought to be responsible for aura and headache in migraine. CSD starts a sterile neuroinflammatory response in brain parenchyma and meninges. cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway is an innate immune system pathway that induces type 1 interferon and inflammatory cytokine synthesis in the cell. It has been shown to have important roles in neuroinflammation and nociception. In this study, we aimed to elucidate the roles of cGAS-STING pathway in CSD-associated neuroinflammation and nociception. CSD was induced with non-invasive optogenetic method in Thy1-ChR2-YFP transgenic mice and cGAS-STING pathway activation in the cerebral cortex was investigated with immunofluorescent staining and capillary based Western blotting (WES). Expression of pathway proteins were assessed in neuron, astrocyte and microglia cell types. Additionally, cGAS-STING pathway activity was pharmacologically manipulated with specific STING antagonist C-176 (20 mg/kg) and STING agonist 2’3’ cGAMP (1 mg/kg) and its effects on CSD-associated microglial activation, CSD susceptibility and CSD-associated nociceptive behaviours were assessed. After CSD induction, cGAS-STING pathway activation and interferon-β synthesis was observed predominantly in neurons in the cerebral cortex with downstream effects on microglial activation. Pathway activation with 2’3’cGAMP decreased CSD susceptibility and significantly alleviated the development of periorbital allodynia following CSD. Our findings suggested that cGAS-STING pathway plays a role in CSD-associated neuroinflammation and nociception and that STING modulation has a therapeutic potential in CSD-associated neurological disorders.
This study is supported by Hacettepe University Scientific Research Projects Coordination Unit (Project no: TSA-2022-19749), Council of Higher Education (100/2000 PhD scholarship) and The Scientific and Technological Research Institution of Turkey (TÜBİTAK, 2211-A PhD scholarship).
PHILIA KAVRAMININ PLASTİK SANATLARDA TEMSİLİ VE SEVGİNİN İMGELEŞMESİ
(Güzel Sanatlar Enstitüsü, 2026) Tolga ERSİN; Seramik ve Cam
This study examines the representations of the concept of love, one of the fundamental elements of human experience, in the plastic arts through the concept of philia in Ancient Greek philosophy and investigates the transformations it has undergone throughout the historical process. The primary aim of the research is to reveal how the concept of love has been interpreted in accordance with the philosophical, cultural, social, and artistic conditions of different periods and through which forms of expression it has been made visible in the plastic arts. Accordingly, the transformation of the concept of love throughout the historical process, extending from Antiquity to the Middle Ages, Renaissance, Enlightenment, Modernism, Postmodernism, and Contemporary Art periods, has been examined. In the research, a literature review was conducted by utilizing scientific, philosophical, sociological, psychological, and art-historical sources; artworks from different periods were examined, museum collections were researched, and visual documentation was carried out. The data obtained reveal that love has been represented in the plastic arts in various forms within the contexts of individual, social, religious, familial, romantic, and cultural relationships. In the practical section of the study, the data obtained from the theoretical research were associated with the researcher’s personal artistic practices produced using ceramic materials. Thus, the process through which the concept of philia is transformed into a tangible art object through form, material, technique, and plastic language was addressed. In addition to examining the philosophical and historical foundations of love within the context of the plastic arts, the study aims to transfer the theoretical data obtained into personal ceramic practices and to integrate the conceptual content with the artistic production process. As a result of the research, it is concluded that although the meaning and forms of expression of the concept of love have changed throughout history, it has maintained fundamental elements such as human relationships, belonging, attachment, and reciprocity; in the plastic arts, however, it has been reinterpreted in different forms depending on the conditions of each period and culture.