Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)

  • HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
 

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Mycobacterium Kansasii İzolatlarında İlaç Direnç Profili ve İlgili Gen Mutasyonları
(Sağlık Bilimleri Enstitüsü, 2025-07-21) Mehmetzade, Hakan Farzin; Mikrobiyoloji
Nontuberculous mycobacteria (NTM) are predominantly environmental bacteria that are categorized into two groups based on their growth rates: slow-growing and rapid-growing NTM. M. kansasii is a slow-growing mycobacterium responsible for tuberculosis-like pulmonary diseases as well as extrapulmonary conditions such as lymphadenitis, skin, and soft tissue infections. This study aimed to determine the minimum inhibitory concentration (MIC) values of 40 M. kansasii isolates that were isolated in Turkey and to investigate mutations in the gyrA, gyrB, rpoB, rbpA, and rrl genes that are associated with drug resistance in resistant isolates. The study was conducted in five stages: conventional drug susceptibility testing, DNA extraction, amplification of gyrA, gyrB, rpoB, rbpA, and rrl genes, Sanger DNA sequencing, and next-generation sequencing. As a result of the study, all isolates were found to be susceptible to amikacin (AMK), clarithromycin (CLA), linezolid (LZD), moxifloxacin (MXF), and rifabutin (RFB); while 90% of the isolates were resistant to ciprofloxacin (CIP) and rifampin (RIF), 47.5% were resistant to doxycycline, and 70% were resistant to trimethoprim/sulfamethoxazole (TMP- SMZ). Susceptibility testing for minocycline could not be performed because minocycline is not included in the Sensititre SLOMYCO panel. Sanger sequencing revealed no mutations in the gyrA, gyrB, or rrl genes. The most frequent mutations in the Rifampin Resistance-Determining Region (RRDR) of the rpoB gene were identified at codons 447 and 457. Notably, for the first time, this study identified mutations outside the RRDR region of the rpoB gene at nucleotides 226, 617, 1191, and 2555. No mutations were detected in the rbpA gene region. This study identified novel mutations in the ropB gene, both inside and beyond the RRDR, in rifampin- resistant isolates.
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Süt Ve Daimi Birinci Büyük Azıların Tedavi Gereksiniminin Cast İndeksiyle Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2025-05-16) İltuş, Tuğçe Melisa; Pedodonti
The aim of this study was to determine the prevalence and severity levels of dental caries in primary and first permanent molars among 7-8-year-old children using the Caries Assessment Spectrum and Treatment (CAST) index and to assess their relationship with DMFT/dmft scores. A total of 101 children (50.5% girls, 49.5% boys) participated in the study. Dental caries assessment was performed using the CAST index, and individual DMFT and dmft scores were calculated. Additionally, a questionnaire was administered to parents to collect information on sociodemographic characteristics, dietary habits, and oral hygiene practices, and Plaque Index and Gingival Index evaluations were performed for all participants. Statistical analyses included descriptive statistics, Chi-Square Test, Mann-Whitney U Test, and Spearman Correlation Analysis (p<0.05). The mean CAST score of the children was found to be 6.15±1.91, indicating a high risk for poor oral health within the study population. No statistically significant difference was observed in CAST scores between genders (p>0.05). Similarly, no significant difference was found in maximum CAST scores with increasing age (p>0.05). However, a statistically significant positive correlation was detected between CAST scores and individual dmft/DMFT scores (p<0.001). In conclusion, the findings demonstrate that the CAST index is an effective tool for the detailed evaluation of caries progression in primary and permanent molars. The study emphasizes the importance of early detection and the necessity of implementing preventive oral health strategies among 7-8-year-old children.
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Daima İkinci Premolar Agenezisi ve Diş Gelişimi Arasındaki İlişkinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2025-06-30) Zeytin, Gamze; Pedodonti
In this study, the presence of mandibular second premolar agenesis, associated dental anomalies, and the effects of second premolar agenesis on dental development were retrospectively evaluated in children aged 5–15 years. A total of 14,460 panoramic radiographs, taken between 2012 and 2023 and archived in the digital database of Hacettepe University Faculty of Dentistry, were examined. The study group consisted of 429 individuals who met the inclusion criteria, and the control group included an equal number of individuals (n=429). In the included cases, the presence of dental anomalies, the intraoral condition of the primary second molars in the region associated with agenesis, and the presence of infraocclusion and root resorption were retrospectively assessed. Dental age estimation and assessment of tooth development stages were performed using the Demirjian method. On average, dental age in the study group was delayed by 0.70 years (approximately 8 months) compared to the control group. The prevalence of second premolar agenesis among the evaluated individuals was 4%. When the developmental stages of the permanent teeth adjacent to the second premolar were assessed in the study group, it was found that the second molars were at earlier developmental stages, and this difference between the groups was statistically significant (p < 0.05). In females, a statistically significant delay in the development of the right mandibular first premolars was observed (p < 0.05). Taurodontism was found more frequently in the study group (7.3%); however, no statistically significant association was found between the presence of taurodontism and second premolar agenesis (p = 0.447). The presence of primary second molars in the mandibular agenesis region was higher; among these teeth, 72.5% exhibited caries or restorations, 25.8% were healthy, and 25.9% presented with infraocclusion. In individuals with second premolar agenesis, early and detailed radiographic evaluations are of utmost importance for the accurate identification of developmental differences and associated dental anomalies, which is crucial for proper clinical management.
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Derin Çürüğün Yumuşak Dentine Kadar Selektif Olarak Uzaklaştırıldığı Dişlerin Pulpasının Korunmasında Kullanılan Kalsiyum Silikat Simanın Etkinliğinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2025-06-25) Kesim, Betül; Restoratif Diş Tedavisi
The aim of this randomized controlled clinical study had been to evaluate the 18-month clinical performance of a resin-modified calcium silicate-based liner material (TheraCal LC, Bisco, Schaumburg, IL, USA) used as a pulp capping agent in teeth with deep carious lesions in which caries had been selectively removed to soft dentin. A total of 94 teeth in 80 patients with deep dentin caries classified as D3 according to the American Dental Association Caries Classification System (ADA CCS) had been included in the study. All clinical procedures had been performed by a single operator under rubber dam isolation. During caries excavation, soft carious tissue had been intentionally left over the pulp to prevent pulp exposure, while the peripheral caries had been removed until hard dentin was reached in order to obtain an appropriate surface for adhesive restoration. The teeth had been randomly assigned to two groups: a test group treated with TheraCal LC (n = 47), and a control group treated with Dycal (Dentsply Caulk, Milford, DE, USA) (n = 47). Over the pulp capping materials, a resin-modified glass ionomer cement (RIVA LC, SDI, Bayswater, Australia) had been applied, and all teeth had been restored with Gradia Direct Posterior (GC Corp., Tokyo, Japan). Clinical evaluations had been conducted at 6, 12, and 18 months by two independent examiners according to the FDI criteria. By the end of the 18-month follow-up period, all teeth in both groups had maintained vitality, and the overall clinical success rate had been determined to be 100%. No difference had been found in clinical performance between TheraCal LC and Dycal. In conclusion, in deep dentin lesions treated with selective caries removal, both TheraCal LC and Dycal had yielded similarly successful clinical outcomes over the 18-month follow-up period.
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Sınıf II Restorasyonlarda Konvansiyonel Bulk-Fill Kompozitler İle Termovisköz Bulk-Fill Kompozitlerin Klinik Olarak Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2025-06-25) Tuncer, Meriç; Restoratif Diş Tedavisi
The aim of this in vivo study was to evaluate the clinical performance of three different bulk-fill composite resin materials applied to Class II cavities over a 12-month period according to modified USPHS criteria. A total of 168 teeth were included in the study. In each patient, the teeth were randomly assigned into three groups. Each patient received at least three separate Class II restorations. A different bulk-fill composite resin was placed in each tooth by a single operator. Each group consisted of 56 teeth, including a control group. The control group (n=56) was restored using Filtek One Bulk Fill Restorative (3M ESPE, Minnesota, USA). One test group (n=56) received an ormocer-based bulk-fill composite resin, Admira Fusion xtra (Voco GmbH, Cuxhaven, Germany), while the other test group (n=56) was restored with a thermoviscous bulk-fill composite resin, VisCalor Bulk (Voco GmbH, Cuxhaven, Germany). All materials were applied in a single four mm increment according to the manufacturers instructions. A universal adhesive system, Futura Bond U (Voco GmbH, Cuxhaven, Germany), was used for all restorations. The restorations were evaluated using modified USPHS criteria by a different examiner at baseline (one week), six months, and 12 months. Statistical analysis was performed using IBM SPSS for Windows 21.0 (Armonk, NY), employing the Likelihood Ratio Test, Marginal Homogeneity Test, and Bonferroni correction. A statistically significant difference was observed within groups in the criterion of anatomical form (p<0.05). However, no statistically significant differences were found among the restorative materials across all other criteria and evaluation periods at the end of 12 months (p>0.05). This clinical study concluded that all three restorative materials the thermoviscous bulk-fill composite resin (VisCalor Bulk), the ormocer-based bulk-fill composite resin (Admira Fusion xtra), and the conventional bulk-fill composite resin (Filtek One Bulk Fill Restorative) exhibited successful clinical performance over the 12-month period according to modified USPHS criteria.