Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
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Recent Submissions
İlişki Etiği Ölçeğinin Azerbaycan Kültürüne Uyarlanması: Kültürlerarası Bir Çalışma
(Eğitim Bilimleri Enstitüsü, 2026) Ayjan ALIYEVA; Rehberlik ve Psikolojik Danışmanlık
The aim of this study is twofold. The first aim is adapting the Relational Ethics Scale into Azerbaijani language and culture, and conducting its validity and reliability study. The second aim is performing a cross-cultural study for Azerbaijani and Turkish cultures within the Relational Ethics Scale's scope. Regarding the first aim, initial translation, a pilot study, and adjustments, Confirmatory Factor Analysis (CFA) was performed using data from 330 Azerbaijani individuals aged 18-35 to evaluate construct validity. Regarding the second aim, measurement invariance analysis was applied after collecting data from 330 Azerbaijani and 327 Turkish participants to determine if the Relational Ethics Scale's Azerbaijani and Turkish forms measure the same construct. As data collection tools, a Personal Information Form the Relational Ethics Scale, and the Young Schema Questionnaire's Entitlement subscale for criterion validity were administered. In the final stage, Measurement Invariance analysis was applied for cross-cultural study. As a result, the Relational Ethics Scale demonstrated a four-dimensional factor structure similar to its original Turkish form, possessing sufficient validity and reliability coefficients to measure romantic relationships' ethical dimensions within the Azerbaijani context. Criterion validity analysis revealed significant relationships between the Relational Ethics Scale's Entitlement dimensions and the Entitlement Schema. Through cross-cultural analyses, configural and metric measurement invariance models were achieved, whereas scalar and strict models could not be achieved. Achieving configural and metric invariance models concluded these forms measure the same construct across both cultures.
PROSTAT KANSERİNDE RİSK STRATİFİKASYONU İÇİN TRANSKRİPTOMİK TEMELLİ BİYOBELİRTEÇLERİN ANALİZİ
(Sağlık Bilimleri Enstitüsü, 2026-07-17) Turhan, Ali Utku; Temel Onkoloji
Turhan, AU., Analysis of Transcriptomic-based Biomarkers for Risk Stratification in Prostate Cancer. Hacettepe University Graduate School of Health Sciences, Tumor Biology and Immunology Program Master’s Thesis, Ankara, 2026. Prostate cancer has a variable clinical course, and current risk assessment is largely based on PSA level, tumor stage, and Gleason score. However, tumor heterogeneity and limited representation by needle biopsies may prevent biopsy-based grading from fully reflecting biological aggressiveness, particularly in biopsy-radical prostatectomy discordance. Although clinicopathological variables and molecular tests contribute to prognostic assessment, their predictive performance, accessibility, and routine applicability remain limited. Therefore, molecular biomarkers that reflect tumor biology and can be evaluated across independent cohorts are needed. In this study, prognostic associations of available genes were investigated in public transcriptomic datasets. TCGA PRAD, GSE220095, and GSE70769 were used for discovery, while DKFZ, GSE116918, and GSE16560 were used for validation. CSRP1 expression was consistently associated with better survival, and multivariable analyses showed that this association was independent of confounding factors. The contribution of CSRP1 to clinical prognostic models was more evident in the Gleason 7 subgroup. After stratification by Decipher risk groups, CSRP1 showed significant prognostic discrimination in low- and intermediate-risk groups. Transcriptomic, mutational, and proteomic analyses showed that low-CSRP1 tumors had more frequent TP53, TTN, and MUC17 mutations, with increased mTORC1-, proliferation-, and lipogenesis-related protein levels. Single-cell RNA-seq analyses showed that CSRP1 expression was mainly observed in the tumor microenvironment, predominantly in smooth muscle cells and fibroblasts, with lower levels in epithelial cells. In vitro, siRNA-mediated CSRP1 knockdown increased cell growth in DU 145 cells. These findings indicate that CSRP1 is a candidate biomarker associated with favorable prognosis in prostate cancer, with consistent performance across cohorts and potential to contribute to clinical risk models.
KENDİNİ KAYBETMEKTEN YENİDEN BULMAYA: TÜRKİYE'DEKİ ULUSLARARASI ÖĞRENCİLERİN SOSYOKÜLTÜREL UYUM YOLCULUĞU
(Eğitim Bilimleri Enstitüsü, 2026-06-29) Sadia Nazir; Rehberlik ve Psikolojik Danışmanlık
This study examines the sociocultural adaptation processes of international students in
Türkiye from a process-oriented and identity-centered perspective. Adopting a qualitative
research design based on the constructivist grounded theory approach, the study draws on
in-depth, semi-structured interviews conducted with 18 international students, primarily in
Ankara, with one participant from Istanbul (online). The data were analyzed through iterative
coding and constant comparative analysis, resulting in 3,224 initial and 478 focused codes
being organized into a three-phase process model. The findings conceptualize adaptation
not as a linear progression, but as a dynamic and non-linear process structured around the
core category of “From Losing to Finding Yourself.”
The initial phase (crisis and disorientation) includes categories such as pre-arrival decision
making and preparation, expectation–reality gap, language barriers, social isolation, and
emotional distress. The middle phase (reorientation and integration) involves the
development of social networks, cultural encounters and negotiation, academic adaptation,
and coping strategies that enable active engagement with the host context. The
transformation phase encompasses categories related to the development of self-efficacy,
positive meaning-making, lifestyle transformation, future orientation, and the construction
of belonging and a sense of home.
The results demonstrate that adaptation is not merely a response to external conditions,
but an active process in which individuals interpret, negotiate, and reconstruct their identities
through ongoing interactions with their social and cultural environments. In this respect, the
study contributes to the literature by reconceptualizing sociocultural adaptation as a
multilayered process shaped by identity transformation, meaning-making, and
subjectification.
GÖRME YETERSİZLİĞİ OLAN ÇOCUKLARDA "ÇOCUKLAR VE GENÇLER İÇİN KATILIM VE AKTİVİTE ENVANTERİ (KAE-ÇG)" `NİN TÜRKÇE GEÇERLİLİK VE GÜVENİLİRLİĞİNİN İNCELENMESİ
(Sağlık Bilimleri Enstitüsü, 2026) Kayım, Aleyna; Ergoterapi
The aim of this study was to translate, culturally adapt, and evaluate the validity and reliability of the Turkish versions of the Participation and Activity Inventory for Children and Youth (PAI-CY) for the 0–2-year and 3–6-year age groups, which assess the participation levels and needs of children with visual impairment in daily life activities. Parents/caregivers of children with visual impairment aged 0–2 years (n = 135) and 3–6 years (n = 175) were included in the study. The linguistic and cultural adaptation process was conducted in accordance with the protocol proposed by Beaton et al. Validity analyses included content validity, construct validity, and known-groups validity. Construct validity was examined using the Graded Response Model (GRM) within the framework of Item Response Theory (IRT), and the assumptions of unidimensionality, local independence, and monotonicity were found to be satisfied for both age versions. Eigenvalue ratios indicated that both versions exhibited unidimensional structure. Known-groups validity analyses demonstrated that the
scales were able to discriminate between children with different levels of visual impairment. Reliability analyses included internal consistency and test–retest reliability. The internal consistency coefficients were found to be Cronbach's α = 0.938 for the 0–2-year version and Cronbach's α = 0.942 for the 3–6-year version. Test–retest reliability was found to be ICC= 0.938 for the PAI-CY 0–2 years and ICC = 0.915 for the PAI-CY 3–6 years. Consequently, the Turkish versions of the PAI-CY 0–2 years and PAI-CY 3–6 years were found to be valid and reliable instruments for assessing participation and activity levels in children with visual impairment aged 0–6 years.
Postmenopozal Kadınlarda Menopoz Semptomları ile Cinsel Yaşam Kalitesi Arasındaki İlişkide Genital Benlik İmajı ve Çift Uyumunun Aracı Rolü
(Sağlık Bilimleri Enstitüsü, 2026) Bircan Beyza Nur; Doğum ve Kadın Hastalıkları Hemşireliği
This descriptive-predictive study was conducted to examine, within the biopsychosocial approach, the mediating roles of genital self-image and dyadic adjustment in the relationship between menopausal symptoms and sexual quality of life in postmenopausal women. The hypotheses that menopause symptoms are negatively associated with sexual quality of life (H1-1), that genital self-image (H1-2) and dyadic adjustment (H1-3) have significant mediating roles in this relationship, and that these two mediators sequentially exert a significant serial mediating effect between menopause symptoms and sexual quality of life (H1-4) were tested. The study was conducted between September 2025 and February 2026 at the Obstetrics and Gynecology Outpatient Clinic of Hacettepe University Adult Hospital with 212 postmenopausal women. Data were collected through face-to-face interviews using the Descriptive Characteristics Data Collection Form, the Menopause Rating Scale, the Female Genital Self-Image Scale, the Revised Dyadic Adjustment Scale, and the Sexual Quality of Life-Female Questionnaire. The mean age of the participants was 55.82±4.36 years. The mean scores of the Menopause Rating Scale, Female Genital Self-Image Scale, Revised Dyadic Adjustment Scale, and Sexual Quality of Life-Female Questionnaire were 23.21±7.06, 19.89±4.68, 48.56±10.92, and 55.24±21.09, respectively. Correlation analyses revealed no significant relationship between sexual quality of life and menopause symptoms (r=-0.076, p=0.268), whereas significant positive correlations were found with genital self-image (r=0.239, p<0.001) and dyadic adjustment (r=0.586, p<0.001). According to the serial mediation analysis, both the total and direct effects of menopause symptoms on sexual quality of life were not statistically significant, and menopause symptoms did not significantly predict either genital self-image or dyadic adjustment. In contrast, genital self-image positively predicted both dyadic adjustment (β=0.142, p<0.05) and sexual quality of life (β=0.160, p<0.01), while dyadic adjustment emerged as the strongest direct predictor of sexual quality of life (β=0.562, p<0.001). Neither the indirect effects through genital self-image and dyadic adjustment nor the serial indirect effect were statistically significant; therefore, hypotheses H1-1, H1-2, H1-3, and H1-4 were not supported in this sample. The findings suggest that sexual quality of life in the postmenopausal period cannot be explained solely by menopause symptoms and that genital self-image, particularly dyadic adjustment, represents important psychosocial factors that should be taken into consideration in this process. Accordingly, it is recommended that nursing interventions aimed at promoting postmenopausal sexual health should include holistic approaches focusing not only on symptom management but also on strengthening genital self-image and supporting dyadic adjustment.