Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
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Recent Submissions
The Role Of Mitochondrial Transporters In Cancer Metabolism
(Kanser Enstitüsü, 2025-08-26) Erdal, Ranya; Temel Onkoloji
Mitochondrial transporters play crucial roles in cellular metabolism; however, the specific substrates and functions of many remain unknown. This study
aimed to identify the physiological substrate and function of SLC25A47, a liverspecific mitochondrial transporter associated with hepatocellular carcinoma. Using
mitochondrial immunoprecipitation and metabolomics approaches in cell lines and
mouse models, we demonstrated that SLC25A47 functions as an exporter of Nacetylglutamate (NAG) from the mitochondrial matrix. Overexpression of SLC25A47
led to the depletion of mitochondrial NAG levels, whereas knockout mice showed
accumulation of NAG in liver mitochondria. NAG is an essential allosteric activator
of carbamoyl phosphate synthetase 1 (CPS1), which is the rate-limiting enzyme of the urea cycle. By modulating mitochondrial NAG levels, SLC25A47 may serve as a novel regulator of urea cycle activity in hepatocytes. Additionally, we identified the mitochondrial protease YME1L1 as a regulator of SLC25A47 protein levels. This study identifies SLC25A47 as a previously uncharacterized component of hepatic nitrogen metabolism and provides new insights into the regulation of ammonia detoxification in the liver.
İnflamatuar Bağırsak Hastalığında Hastalık Tanısını ve Aktivitesini Belirlemede Belirteçlerin Önemi
(Sağlık Bilimleri Enstitüsü, 2025-08-24) Çetinkaya, Erdinç; Dahili ve Cerrahi Araştırmalar
The aim of this study is to comparatively analyze the levels of selected pro-inflammatory and cytotoxic markers in pathologically inflamed mucosal regions and macroscopically healthy mucosal tissues of patients diagnosed with Inflammatory Bowel Disease (IBD). Between March 2025 and June 2025, patients who were newly diagnosed with IBD after endoscopy were included in the study at Ankara Bilkent City Hospital. Biopsy samples were collected from both macroscopically healthy and pathological mucosa during colonoscopy. Quantitative measurements were performed for interleukins (IL-17A, IL-2, IL-4, IL-10, IL-6), apoptosis-related molecules (Fas, Fas Ligand [FasL]), and cytotoxic response indicators (IFN-γ, Granzyme A, Granzyme B, Perforin, Granulysin). Significant elevations in IL-6, Fas, Granzyme B, and Perforin levels were observed in pathological mucosa. Conversely, Granzyme A levels were found to be significantly higher in normal mucosa compared to pathological mucosa. Correlation analysis revealed a significant positive relationship between age and Granzyme B and Perforin levels. IL-6, Fas, Granzyme B, and Perforin demonstrated high discriminative power in distinguishing pathological tissue presence. No significant correlations were found between these markers and white blood cell count, CRP, platelet count, or hemoglobin levels. In conclusion, the assessment of biopsy-based inflammatory and cytotoxic marker levels in patients with IBD offers a scientific foundation for the development of personalized therapeutic strategies tailored to the molecular characteristics of the disease.
Primer Dismenoresi Olan Sağlıklı Bireylerde Ağrı Nörobilim Eğitimi ile Biyomedikal Ağrı Eğitiminin Etkilerinin Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2025-08-26) Erol, Büşra Nur; Fiziksel Tıp ve Rehabilitasyon
The aim of this study was to compare the effects of pain neuroscience education (PNE) or biomedical pain education (BPE) combined with exercise training (ET) in primary dysmenorrhea (PD). In the study, 38 individuals with PD were randomly assigned to Group 1 (ET+PNE, n=19) or Group 2 (ET+BPE, n=19). Individuals were assessed 3 times: after the first menstruation after inclusion, after the interventions during two menstrual cycles, and 1 month after the end of the interventions. The primary outcome measure was menstrual pain intensity. Secondary outcome measures were menstrual stress, somatic and emotional symptoms associated with central sensitization, pain catastrophizing, pain beliefs, depression-anxiety-stress, quality of life (QoL), and individuals' perception of change in menstrual pain and symptoms. As a result of the study, it was found that the levels of menstrual pain and stress, central sensitization, pain catastrophizing, pain beliefs (except psychological belief in Group 1, and organic and psychological belief in Group 2), and emotional symptoms decreased, and the QoL increased in various subdomains (except psychological dimension in Group 1, and social and environmental dimensions in Group 2) in both groups (p<0,05). In addition, PNE was found to be more effective in reducing menstrual pain, central sensitization, pain catastrophizing, organic pain beliefs and emotional symptom levels, and increasing the physical subdomain of QoL after the intervention or at follow-up compared to BPE (p<0,05). Menstrual stress, helplessness and magnification subdomains of pain catastrophizing, psychological pain beliefs, and psychological, social, and environmental subdomains of QoL improved at similar levels in the groups (p>0,05). In conclusion, it can be said that PNE or BPE combined with exercise is effective in PD management, but PNE is more effective than BPE. Further studies in which PNE is combined with different training parameters and different physiotherapy methods can be planned.
Kalıtsal Metabolik Hastalıklarda Yeni Nesil Omiks Profilleme Uygulamaları
(Sağlık Bilimleri Enstitüsü, 2025-08-18) Şahiner Yurteri, Buket; Çocuk Sağlığı Enstitüsü
This study aimed to characterize disease-specific biomarkers and metabolic alterations by comparing the metabolomic and lipidomic profiles of patients with phenylketonuria (PKU), mild hyperphenylalaninemia (HFA), tetrahydrobiopterin (BH4)-responsive HFA, biotinidase deficiency, and hyperlipidemia—diagnosed through established clinical and routine biochemical analyses—together with one patient carrying a pathogenic VARS2 mutation identified by whole-exome sequencing, and one undiagnosed patient, against healthy controls.
Distinct metabolites showing significant alterations compared to healthy individuals were identified in each phenotype, and these metabolites demonstrated potential biomarker properties. Moreover, pronounced disease-specific metabolic pathway alterations were observed in all patient groups, alongside a set of commonly affected fundamental biological processes.
In PKU patients, differential metabolic fingerprints were detected depending on the clinical classification and metabolic control status, leading to the identification of novel candidate biomarkers for monitoring metabolic control. In biotinidase deficiency, the observed lipid imbalances were found to potentially disrupt cellular energy production and signaling pathways, underscoring the importance of biotin supplementation and dietary regulation. Additionally, the metabolic differences identified in the individual harboring a VARS2 gene mutation contributed to a better molecular understanding of the disease and provided valuable insights for the development of targeted therapies.
In conclusion, this study highlights the significant potential of metabolomic and lipidomic profiling in phenotypic stratification, elucidation of disease mechanisms, and the discovery of novel disease-specific biomarkers.
İÇ MEKÂN SÖYLEMİNİN DEĞİŞİMİ “THE ARCHITECTURAL REVIEW” ÜZERİNE BİR İNCELEME
(Güzel Sanatlar Enstitüsü, 2026) Sibel Aktekin; İç Mimarlık ve Çevre Tasarımı
This study aims to examine the transformation of the discourse on interior spaces within a historical context through periodicals, thereby revealing how this discourse is constructed within periodicals as a field of knowledge production. To this end, the written representations that constitute the discourse on interior spaces have been evaluated as documents that make the production processes of this discourse traceable, and the analysis of these texts has been adopted as the primary research approach.
Accordingly, the study’s dataset was constructed using “The Architectural Review”, a journal published continuously since 1896 that offers extensive content on the discourse of interior space. Texts in the journal were screened using predefined keywords, and following a multi-stage selection process, 518 texts directly related to the discourse of interior space were included in the analysis. These texts were analyzed to determine the themes around which the discourse is structured, the approaches used to address these themes, and the methods and tools upon which they are grounded. This multifaceted analytical approach aims to make the structural components of interior discourse visible through comparative analysis and, thereby, to define a field of knowledge production that expands the theoretical framework of interior discourse.