Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
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ÜÇ BOYUTLU YAZICI ARACILIĞI İLE HAZIRLANAN MİR- 132 VE TRANSFORME EDİCİ BÜYÜME FAKTÖRÜ-ß3 YÜKLÜ LİPOZOM İÇEREN DUAL ETKİLİ KİTOSAN HİDROJEL İSKELELERİNİN TEDAVİ ETKİNLİĞİNİN YANIK YARASINDA DEĞERLENDİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2026-09-02) SEZER AYSİMA; Eczacılık Temel Bilimleri
Although mortality rates in burn injuries have decreased, hypertrophic scarring that develops after burns reduces the quality of life of individuals and adversely affects their social participation. In this thesis, the combined use of the anti-inflammatory and pro-angiogenic effects of the miR-132 mimic together with the antifibrotic effect of TGF-β3 was employed to reduce persistent inflammation and TGF-β1-associated scar formation, thereby aiming to accelerate burn wound healing and to promote scarless healing. For this purpose, TGF-β3 was encapsulated into DOTMA/DOPC/CHOL-based cationic liposomes, while the miR-132 mimic was electrostatically complexed with liposomes to prepare lipoplex formulations. To enhance transfection efficiency, the PEGylated formulations were optimized by targeting a particle size of 100–200 nm and a zeta potential equal to or greater than +40 mV. The antifibrotic efficacy of the formulations was evaluated in a fibrosis model induced with TGF-β1 in L929 cells at the gene and protein levels by RT-qPCR and ELISA, respectively. Combined treatment optimized the COL1/COL3 ratio and produced a balanced antifibrotic response in collagen, MMP13, MMP9, RASA1 and cytokine levels. TGF-β3-loaded liposomes and miR-132-loaded lipoplexes were incorporated into chitosan-based hydrogel scaffolds fabricated by 3D printing in order to provide local and controlled release. The optimized hydrogel formulation exhibited appropriate printability and rheological properties; dispersion of the liposomes/lipoplexes within the hydrogel altered the swelling, degradation and mechanical properties, and the structural properties were evaluated by SEM, DSC and FTIR analyses. In the release studies, TGF-β3 release continued over 312 h and reached 96.64%, whereas 9.84% release was obtained from the miR-132 lipoplexes over the same period, with burst release being limited. In a murine burn wound model, the hydrogel scaffold containing miR-132 and TGF-β3 together accelerated wound closure between days 7 and 15 and regulated the COL1/COL3 ratio. Preservation of α-SMA levels in the combination group indicated that myofibroblast activity and contractile capacity were maintained during extracellular matrix remodelling. In conclusion, co-delivery of miR-132 and TGF-β3 from 3D-printed chitosan hydrogel scaffolds via liposome/lipoplex systems was shown to be a promising dual-acting approach for regulating inflammatory and fibrotic processes in burn wounds and for supporting scarless wound healing.
Kolorektal Kansere Bağlı Kolostomisi Olan Bireylerde Travma Sonrası Büyüme: Tanımlayıcı Nitel Çalışma
(Sağlık Bilimleri Enstitüsü, 2026-08-20) Emir Erkazancı, Gizem; Psikiyatri Hemşireliği
This study aimed to explore the experiences of post-traumatic growth among individuals living with a colostomy associated with colorectal cancer. The study was conducted using a descriptive qualitative design. The study population consisted of individuals with a colostomy who visited three firms selling stoma and wound care products to purchase stoma supplies. Using criterion sampling, the sample comprised 20 participants who met the inclusion and exclusion criteria. Data were collected using a "Descriptive Information Form" and a "Semi-Structured Interview Form" developed by the researchers. Semi- structured interviews were conducted either face-to-face or online. Following completion of the interviews, the audio recordings were transcribed verbatim and analyzed using inductive content analysis, resulting in four themes and ten subthemes. The subthemes of ''Shattering Experiences'' were ''Loss'' and ''The Unknown''; the subthemes of ''Dynamics Facilitating Growth'' were ''Support Systems'', ''Adaptation Strategies'', and ''Inner Resources''; the subthemes of ''Growth Experiences'' were ''Reframing the Self'' and ''Reconstruction of Values''; and the subthemes of ''Recommendations Informed by Experience'' were ''Individual Oriented'', ''Social Environment-Oriented'', and ''Service- Oriented''. Participants experienced cancer and colostomy as shattering experiences; social support, coping strategies, and inner resources provided a foundation for growth, while post-traumatic growth was experienced through changes such as enhanced interpersonal relationships, a greater appreciation of life, and spiritual transformation. It is recommended that the elements identified by participants as reflecting their growth experiences be considered by consultation-liaison psychiatric nurses as components in the development of counseling and intervention programs aimed at supporting individuals with a colostomy due to colorectal cancer in achieving growth through this experience, and that the effectiveness of these interventions be tested in experimental studies.
Yedisu Bölgesi Kurganlarının Tarihi ve Kültürel Açıdan Değerlendirilmesi
(Sosyal Bilimler Enstitüsü, 2026) Gülşah Çoban Akkıyal; Tarih
Inner Asia has historically served as a dynamic crucible of intense political, cultural, and ethnic mobility, functioning as the primordial homeland for nomadic societies such as the Turks and Mongols. Characterized primarily by pastoralism and seasonal migrations between summer and winter pastures, these steppe communities utilized portable tents as their most practical adaptation to nomadic life. Concurrently, recent archaeological excavations demonstrate that urban traditions also emerged within this nomadic landscape, beginning as early as the Saka period. This regional dynamism and socio-economic prosperity were profoundly catalyzed by the Great Silk Road, which expanded trade volumes, diversified social capacities, and funded monumental architecture alongside the exceptionally rich funerary contexts discovered today.
Representing all these dense historical characteristics, the Yedisu (Semirechye) region, encompassing a vast territory in southeastern Kazakhstan, stands out as a critical transit zone and a cultural hub for travelers and merchants alike. Consequently, the area preserves an extraordinary abundance of archaeological, written, and architectural remains, including ancient cities, fortresses, graves, tombstones, rock paintings, balbals, and stone statues.
This thesis focuses specifically on the kurgans of the Yedisu region, which constitute the richest repository of archaeological data available for tracing the developmental trajectory of Turkic cultural history back to its earliest epochs. By analyzing distinct kurgan groups dating between the 8th century BC and the 3rd century AD, this study comprehensively examines the material culture and historical traces of early nomadic societies, focusing predominantly on the Saka and Wusun communities.
SANAT TARİHİNİ SAKATLAMAK: CRIP ESTETİK/SANAT
(Sosyal Bilimler Enstitüsü, 2026-08-24) Ahu Defne Mostowfi Asmaz; Sanat Tarihi
This study examines crip art practices and disability art creations emerging alongside the disability rights movement, utilizing a cripistemological method grounded in disability experience. Its primary objective is to examine the notably limited presence of the crip art movement within Turkish art historiography, despite its growing international visibility and institutional recognition, and to respond to a significant theoretical gap in the field.
Grounded in critical disability studies, this research critically examines the normative construction of the modern subject and the representational regimes through which non-normative bodyminds are framed. It explores how ableism, cure-oriented thinking, and normative body politics are reproduced within artistic production and everyday cultural representation, while foregrounding crip strategies of resistance emerging from lived disability experience.
Furthermore, the study analyzes how crip art practices have transformed alongside the historical trajectory of disability culture and academic debates. It evaluates the creative possibilities, political imaginaries, tensions, and crises of representation opened up by crip bodyminds in performance, public space, and aesthetic production. After discussing canonical examples from the Global North and key debates, the study turns to performative movements at the intersection of disability and art in Türkiye, critically addressing their discursive contradictions and limitations from a cripistemological position.
Ultimately, the research aims to render visible the artistic labor, experiences, and knowledge production of disabled subjects long excluded from Turkish art historical inquiry; frequently positioned as objects of therapy or pity rather than equal research subjects. Through specific case studies, the study discusses processes of invisibilization, paternalistic pressures, tokenism, and internalized ableism, revealing them as urgent problems for art historiography, education, and curatorial practice. Bringing the aesthetic dimensions of contemporary disability studies and crip methodology into the Turkish context, the thesis demonstrates the profound epistemological and aesthetic significance of embodied crip knowledge for artistic production, curatorial practice, and art history.
HARP VE ESARET: BİRİNCİ DÜNYA SAVAŞI VE AZERBAYCAN’DA OSMANLI ESİRLERİ (1915-1918)
(Sosyal Bilimler Enstitüsü, 2026-07-02) ASKER Ali; Tarih
This study examines the fate of Ottoman soldiers captured by Russian forces on the Caucasus Front of the
First World War, focusing on the Nargin prisoner-of-war camp off the coast of Baku. The primary period
of analysis is 1915-1918, with limited reference to 1914 for the camp’s establishment and to 1926 for the
legal and administrative consequences of repatriation. Methodologically it rests on the source-critical,
cross-reading analysis of archival material from the Russian Federation, Türkiye and Azerbaijan, together
with contemporary press and memoirs. The study tests five hypotheses: (1) The Tsarist administration’s
discriminatory policies toward its Muslim subjects, together with shared bonds of religion, language and
belonging, jointly shaped the social foundations of Caucasus Muslims’ solidarity with Ottoman prisoners.
(2) Violence and loss of life during transfer and assembly were linked not only to isolated incidents but also
to administrative fragmentation, logistical deficiencies, gaps in oversight and regional conflict. (3)
Bolshevik institutions targeted prisoners of war through propaganda and organizational initiatives, while
prisoners’ political orientations and visions of the future remained heterogeneous. (4) Multiple and
competing authorities seriously weakened in practice the state responsibility and effective control
mechanisms underpinning the Hague Conventions. (5) Rather than a principal determinant of Turkish
Soviet relations, the 1920-1926 repatriation initiatives served as a testing ground revealing the parties’
diplomatic cooperation and administrative capacity. The findings support these hypotheses to varying
degrees. The main findings are: the Baku Muslim Charitable Society and other local relief organizations
contributed to improving prisoners’ access to food, medical care, and protection. Following the Treaty of
Moscow of 16 March 1921, repatriation was regulated by the Convention on the Repatriation of Prisoners
of War of 28 March 1921. Law No. 750 of 22 February 1926 then allowed a “transfer of nationals” through
embassies and consulates instead of the procedure prescribed by the Convention.