Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
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TÜRK MÜZİĞİ SAZ İCRACILIĞINDA KLASİK KEMENÇE VE KEMAN ETKİLEŞİMİNİN ÖRNEK İCRACILAR ÜZERİNDEN İNCELENMESİ
(Güzel Sanatlar Enstitüsü, 2026-07-22) Hande KARAKOÇ; Geleneksel Türk Müzikleri
Turkish instrumental music has evolved into diverse performance styles and approaches
influenced by cultural structures. These diverse performance styles and approaches have
further broadened due to the influence of other cultural groups. This richness in performance
styles has resulted in the further development of performance techniques over time.
Instruments often played together in musical ensembles have absorbed each other's
performance techniques and styles, thus interacting with each other. The experience of such
interactions, particularly with the violin and kemençe (a type of Turkish stringed
instrument), and their subsequent reflection in performance, forms the central focus of this
study. The aim of this study is to analyze violin and kemençe taksims (improvisations)
technically and melodically, to highlight the characteristic structures of these taksims, to
reveal common performance elements in instrumental pieces played by both violin and
kemençe, and to identify points of similarity between the two instruments. In this study,
eight violin taksims and four kemençe taksims were dictated, and analyses were carried out
in terms of technical-melodic aspects, bowing techniques, core melodic structures, and the
formal structures of the taksims. In addition, common and similar performance elements
were analyzed in instrumental pieces performed jointly by both instruments.
This research utilized data collection and analysis techniques found in qualitative research
methods. Musical analysis and content analysis methods constitute the data analysis methods
of this research.
The study revealed the existence of interaction between the violin and the kemençe (a type
of Turkish string instrument), and identified common and similar performance elements.
DEMİR TOZU KATKILI KİL BÜNYELERİN MIKNATISLARLA ŞEKİLLENDİRİLEREK SERAMİK ESERLERİN OLUŞTURULMASI
(Güzel Sanatlar Enstitüsü, 2026) Simge Okudur; Seramik ve Cam
With advancing technology, magnets have integrated into artistic practices as physical materials, transforming into an innovative forming tool within contemporary ceramic art. This study focuses on the technique of ceramic forming via magnets, which is an area where practical, systematic data in ceramic literature has not yet sufficiently accumulated. Within the framework of studio practice, the variables determined within the scope of the research and their effects were investigated, and the resulting visual and structural findings were evaluated.
Within the scope of the research, composite mixtures responsive to magnetic fields were attempted to be obtained by incorporating iron powder into ceramic clay at varying ratios. Throughout the application process, the consistency of the composite mixture was identified as the most critical element determining the balance between the forming behavior of the body and its mechanical strength. In addition to this, different structures of commercial iron powders, clay bodies, polymeric binders, and magnetic pole configurations were also tested. It was observed that all these variables yielded diverse outcomes regarding the morphological structure, mechanical strength, and aesthetic character of both the mixture and the shaped forms. For instance, no magnetic forming response could be obtained from the mixtures containing 25% iron powder.
On the other hand, it was experienced that the bisque and glaze firing stages are of critical importance in terms of the final structural stability and surface aesthetics of the composite body. Post-firing structural fragility and powdering issues induced by the iron powder were encountered in certain composite bodies; a solution proposal was developed through a newly designed firing program utilizing metal-ceramic interface bonding principles. Driven by the findings obtained following the application processes, original ceramic artworks were created within the possibilities and limitations of magnetic field dynamics, adding richness to the visibility of the technique's aesthetic potential. Unlike the approaches of the pioneersof the technique, these artworks, in which traditional and magnetic forming methods are used together, are aimed to contribute to future studies.
SODYUM GLUKOZ KOTRANSPORTER-2 İNHİBİTÖRLERİNİN ALZHEİMER HASTALIĞI BENZERİ MODELDE NLRP3 İNFLAMAZOMU ARACILI NÖROİNFLAMASYON ÜZERİNE ETKİSİ
(Sağlık Bilimleri Enstitüsü, 2026-09-25) Mercan Buse Esra; Farmakoloji
Neuroinflammation, particularly microglial activation and NLRP3 inflammasome-mediated inflammatory responses, is an important component of Alzheimer’s disease (AD) pathogenesis. In addition to their glucose-lowering effects, sodium-glucose cotransporter-2 (SGLT-2) inhibitors have been shown to exert anti-inflammatory effects, which may be partly associated with suppression of the NLRP3 inflammasome. However, the effects of SGLT-2 inhibitors on NLRP3 inflammasome-related inflammatory responses under AD-like conditions have not yet been fully elucidated. In this study, the effects of bexagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and canagliflozin were evaluated in amyloid beta (Aβ)- and lipopolysaccharide (LPS)-induced BV2 microglial inflammation models using MTT, Griess, Western blot, and ELISA assays. In the Aβ model, bexagliflozin significantly reduced NLRP3, ASC, and caspase-1 protein levels as well as IL-1β and IL-18 levels, whereas dapagliflozin reduced NLRP3 and ASC protein levels and both cytokines. Ertugliflozin and canagliflozin showed more selective effects, while empagliflozin did not produce significant changes in the evaluated markers. In the LPS model, all five inhibitors significantly reduced NLRP3, ASC, IL-1β, and IL-18 levels, whereas caspase-1 was reduced only by bexagliflozin and empagliflozin. These findings support the further evaluation, particularly of bexagliflozin and dapagliflozin, in mechanistic and preclinical studies as potential pharmacological candidates targeting the NLRP3 axis in AH-associated neuroinflammation.
THE BALANCE OF POWER POLITICS IN THE EASTERN MEDITERRANEAN: EXPLAINING THE US APPROACH TOWARD TÜRKİYE AND GREECE
(Sosyal Bilimler Enstitüsü, 2026) EMRE ÖZER; Uluslararası İlişkiler
This thesis analyzes whether Greece has become an intra-alliance balancing actor in the United States policy toward Türkiye within the framework of deepening strategic relationship between the United States and Greece since 2016. The theoretical framework is based on neorealist balance of power theory and the alliance literature. In this study, intra-alliance balancing refers to a strategy to alter patterns of dependence, expand strategic options and influence leverage among allies with different interests and threat perceptions. The study uses qualitative document analysis to examine official U.S. strategy documents, defense agreements, legislation, congressional hearings, statements at the presidential and ministerial levels, military doctrines, and relevant secondary literature.
Tutuklama Kararlarında Gerekçe
(Sosyal Bilimler Enstitüsü, 2026) Berfin BOZDEMİR; Kamu Hukuku
This study examines the measure of detention, the most serious interference with the right to liberty and security of person in Turkish Criminal Procedure Law, from the perspective of the obligation to "provide justification." The fundamental problem of the thesis is that, despite being a constitutional and legal obligation, detention orders in judicial practice are frequently issued with "pre-printed justifications" lacking concrete facts, and this situation transforms detention from a protective measure into a tool of "pre-emptive punishment."
The first part of the study examines the legal nature of detention in light of the principles of the rule of law and the presumption of innocence. By emphasizing that detention is exceptional, temporary, and a "last resort" (ultima ratio), it is demonstrated that this measure can only be used to ensure the integrity of the trial. The second part focuses on the functions of a reasoned decisionof the arrest warrants. The functions of the justification—preventing arbitrariness on the part of the judge, ensuring that the decision is based on rational grounds, and most importantly, enabling the defense to effectively exercise its right to appeal—are analyzed. Furthermore, it has been argued that the judge's discussion of the evidence in the arrest warrant does not constitute "prejudgment," but rather a legal obligation.
In the third and main section of the thesis, the material and formal elements that must be present in an arrest warrant pursuant to Article 101/2 of the Code of Criminal Procedure are examined within the framework of strong suspicion of crime, the requirement of concrete evidence, grounds for arrest (suspicion of escape and tampering with evidence), catalog crimes, and proportionality criteria. In particular, the requirement of "explaining with concrete facts why judicial control would be insufficient," is evaluated in light of current Constitutional Court and ECHR jurisprudence.
In conclusion, the thesis argues that the arrest regime in the Turkish judicial system should be freed from its "automated" and "standardized" structure and transformed into an individualized, persuasive, and verifiable reasoned structure according to the specifics of each concrete case. It is suggested that, in order to prevent arrest from leading to a human rights crisis, priority should be given to judicial control measures, judicial personnel should be trained in this area, and decisions without justification should trigger compensation liability and recourse mechanisms.