Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Communities in DSpace
Select a community to browse its collections.
- Ankara State Conservatory
- Directorates
- Faculty of Dentistry
- Faculty of Pharmacy
- Faculty of Letters
Recent Submissions
Nanotopografinin Stromal Hücre Davranışı Üzerine Etkisinin Moleküler Düzeyde Araştırılması
(Sağlık Bilimleri Enstitüsü, 2025-07-11) Taşdemir, Nur Kübra; Dahili ve Cerrahi Araştırmalar
In this study, the effects of nanotopographical modifications on titanium surfaces—achieved via electrochemical anodization—on mesenchymal stem cell (MSC) behavior were investigated. Nanotube surfaces generated under various anodization parameters were evaluated in terms of cellular adhesion, spreading, viability, and regenerative responses at the molecular level. Surface characterization revealed significant variations in physicochemical properties such as morphology, surface energy, and surface potential. These differences directly influenced cellular adaptation, oxidative stress responses, and susceptibility to apoptosis. Molecular analyses demonstrated that the cellular responses to these surfaces were not limited to morphological changes but also involved substantial genetic modulation. In particular, upregulation of genes associated with cytoskeletal organization, extracellular matrix production, angiogenesis, and migration indicated that certain nanotopographic variants promote regenerative processes. Conversely, the downregulation of genes related to ribosomal proteins suggested that cells prioritize energy management during adaptation to the modified microenvironment. The findings reveal that surface nanotopography functions not merely as a passive physical substrate but as an active biological parameter capable of directing cell fate. Notably, some surface designs were shown to activate gene pathways that enhance regenerative responses, positioning them as strong candidates for future biomedical applications. This dissertation deepens the understanding of the interface between surface engineering and cellular behavior and offers novel insights for the design of more effective biomaterials in tissue engineering.
Ekmeğe Avokado İlavesinin Antioksidan Kapasite Ve İn Vitro Glisemik İndeks Üzerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2025-08-03) Uçar, Enes Mustafa; Beslenme ve Diyetetik
White bread, a primary energy source in
Turkish society, is known to have a high glycemic index (GI) and low total phenolic content and
antioxidant capacity. This study investigated the effects of substituting 5–10% avocado powder for
wheat flour on the bread's chemical composition, total phenolic content determined by the Folin-
Ciocalteu method, and antioxidant capacity assessed by 2,2′-azinobis-(3-ethylbenzothiazoline-6-
sulfonic acid) (ABTS) and ferric reducing antioxidant power (FRAP) methods. In addition to the texture
properties, color parameters, and starch digestibility of fresh breads obtained by baking at 200°C for 20
minutes, breads that were fully baked and stored frozen at –20°C for 7 days and breads produced by
pre-baking at 170°C for 10 minutes, storing frozen at –20°C for 7 days and re-baking at 220°C for 11
minutes were evaluated. In vitro starch digestion was performed to obtain both starch fractions and
estimated GI (tGI). In addition, scanning electron microscopy (SEM) analysis was performed to analyze
the microstructure of the bread crumb. As a result of the analyses performed in triplicate, the protein
and fat contents of the breads did not change significantly with avocado powder substitution, while the
ash and dietary fiber contents increased significantly (p<0.05). With the substitution, the total phenolic
content of bread per 100 g dry weight increased from 75.53±4.22 mg gallic acid equivalent (GAEq) to
123.67±10.99 mg GAEq; antioxidant capacity increased from 97.20±4.78 μmol Trolox equivalent
(TEq) to 303.37±19.03 μmol TEq by the ABTS method and from 161.10±2.12 μmol TEq to
370.13±43.07 μmol TEq by the FRAP method (p<0.05). However, it was found that the substitution
decreased the volume and specific volume in breads, caused darkening of the crust and crumb color,
decreased the yellowness (bi) value in the crust, decreased the redness (ai) value in the bread, and
increased the bi value (p<0.05). Furthermore, avocado powder substitution increased the hardness,
gumminess, and chewiness of breads, while significantly decreasing the elasticity, cohesiveness, and
springiness values (p<0.05). On the other hand, it caused a decrease in the level of rapidly digestible
starch in fresh breads from 56.70±1.35% to 40.19±1.63% and an increase in the contents of slowly
digestible and resistant starch from 34.28±0.47% to 44.14±1.33% and from 9.01±1.11% to
16.40±0.72%, respectively (p<0.05). These results were accompanied by a decrease in the tGI value
from 94.61±0.53 to 83.95±0.30 (p<0.05). These potential benefits of avocado bread will contribute to
the acceleration of positive human health. Future research should validate the nutritional benefits of this
bread model through human studies and assess its clinical relevance.
MİKOZİS FUNGOİDES, PSORİASİS VE ATOPİK DERMATİT HASTALARINDA DERMOSKOPİK BULGULARIN İNCELENMESİ
(Tıp Fakültesi, 0010-09-20) Batuhan Kerem BALAN; Neslihan AKDOĞAN; Deri ve Zührevi Hastalıkları
Balan B. K. Dermoscopic Evaluation of Patients with Mycosis Fungoides,
Psoriasis, and Atopic Dermatitis. Hacettepe University Faculty of Medicine,
Department of Dermatology and Venereology, Medical Specialty Thesis. Ankara,
2025. Mycosis fungoides (MF), psoriasis (PSO), and atopic dermatitis (AD) are
chronic skin diseases with overlapping clinical features. This study aimed to compare
dermoscopic findings among these three conditions and to identify diagnostic features
that may assist in clinical differentiation. A total of 159 patients (MF n: 55, PSO n: 53,
AD n: 51) were included. Dermoscopic evaluation was performed in all patients, and
findings were compared based on defined parameters. Linear and spermatozoa-like
vessels were significantly more frequent in MF and AD, while dotted vessels were
predominant in PSO (p < 0.001). Uniform vascular distribution was common in PSO,
whereas clustered or nonspecific patterns were more frequently observed in MF and
AD (p < 0.001). Polymorphous vascular patterns were significantly more common in
MF and AD and rare in PSO (p < 0.001). Although scale was present in all groups, it
typically followed skin furrows in MF and appeared orange in AD (p < 0.001). Focal
white structureless areas and focal orange discoloration were significantly more
common in MF, while ulceration and dystrophic hairs were predominant in AD (p <
0.001). A bright red background was characteristic in PSO, whereas pink or pale red
backgrounds were more frequent in MF and AD (p < 0.001). Ultraviolet (UV) mode
dermoscopy enhanced the visualization of scale and structureless areas in all groups.
This study quantitatively compared dermoscopic findings in MF, PSO, and AD for the
first time at this scale, revealing distinct vascular and structural patterns. The presence
of linear and spermatozoa-like vessels and focal orange discoloration in MF, along
with orange scales and ulceration in AD, may provide valuable diagnostic clues.
Servikal Radikülopatisi Olan Bireylerde Fizyoterapi Ve Rehabilitasyonun El Fonksiyonları Üzerindeki Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2025-07-23) Eren, Tuba; Fizyoterapi ve Rehabilitasyon
This study aimed to
evaluate the sensorimotor changes and bilateral involvement patterns in the upper
extremity associated with different nerve root levels in individuals with unilateral
cervical radiculopathy (CR), and to examine the effects of a conventional
physiotherapy program on these changes and the differential responses according to
the level of involvement. The study included 58 participants diagnosed with CR at the
C5, C6, and C7 levels or with non-specific neck pain (NSNP). All participants received
structured conventional physiotherapy (hot pack, TENS, ultrasound, and cervical
stabilization exercises) three times per week for 6 weeks. Assessments were conducted
before and after treatment, focusing on the cervical region (pain, range of motion,
disability), upper extremity (muscle strength, grip strength, sensation, hand dexterity,
functional status), and emotional state (kinesiophobia, depression, anxiety). In
addition, bilateral evaluations were performed to analyze changes in the unaffected
extremity. At baseline, the C7 group demonstrated more pronounced impairments in
hand function and median nerve sensory function, with the lowest muscle strength and
hand dexterity scores. Following treatment, all groups showed significant
improvements in muscle strength, grip strength, and sensory parameters (p<0.05);
however, limited improvement was observed in certain motor and sensory parameters
in the C6 and C7 groups. Median nerve sensory deficits and hand dexterity limitations
persisted in the C7 group after treatment. All groups demonstrated improvements in
DASH scores (p<0.05), though the C7 group showed a lesser degree of improvement.
Emotional parameters also improved across all groups (p<0.05), except for
kinesiophobia in the C7 group, which did not show significant change. In conclusion,
patients with C7-level CR exhibited a more resistant clinical profile with pronounced
bilateral involvement, highlighting the need to individualize physiotherapy approaches
according to the radiculopathy level. In this context, four hypotheses were formulated
and tested to investigate whether the effects of physiotherapy on hand functions,
sensorimotor performance, functional status, emotional state, and kinesiophobia differ
according to the level of cervical radiculopathy.
OBSTRÜKTİF UYKU APNE SENDROMUNDA CERRAHİ TEDAVİ UYGULANAN VE CERRAHİ UYGULANMAYAN HASTALARDA SÜREKLİ POZİTİF HAVAYOLU BASINCI (CPAP) BASINÇ PARAMETRELERİNİN KARŞILAŞTIRILMASI
(Tıp Fakültesi, 2027-01-27) Elmaddin Mahyaddinov; Kulak Burun Boğaz
ABSTRACT
Mehyettinov Elmettin, Comparison of Continuous Positive Airway Pressure (CPAP) Pressure Parameters in Patients With Obstructive Sleep Apnea Syndrome Treated With and Without Surgery, Hacettepe University Faculty of Medicine, Department of Otorhinolaryngology, Ankara, 2026.
Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by recurrent upper airway collapse and associated with significant cardiovascular and neurobehavioral consequences. Continuous positive airway pressure (CPAP) therapy is accepted as the first-line treatment for OSAS; however, surgical treatment options are considered in patients who are unable to tolerate or refuse CPAP therapy. Nevertheless, clinical and polysomnographic data regarding patients in whom OSAS is not completely resolved after surgery and in whom CPAP therapy is reintroduced remain limited in the literature.
The aim of this study was to evaluate the clinical and polysomnographic characteristics of patients with persistent CPAP requirement following OSAS surgery and to compare patients treated with surgery plus CPAP and those treated with CPAP alone. A total of 67 patients diagnosed with OSAS and presenting with a postoperative apnea–hypopnea index (AHI) ≥15 on polysomnography were included in the study. Patients were divided into two groups: surgery plus CPAP and CPAP alone. Demographic characteristics and preoperative and postoperative polysomnographic parameters were retrospectively analyzed.
Comparison of postoperative parameters between the groups revealed that minimum oxygen saturation was significantly higher in the surgery plus CPAP group. In addition, prone position AHI values were significantly lower in the surgery plus CPAP group. However, no statistically significant differences were observed between the groups in terms of overall AHI, oxygen desaturation index (ODI), CPAP pressure requirement, or Uyku etkinliği. In patients with persistent CPAP requirement after surgery, residual disease burden was particularly associated with oxygenation and positional apnea parameters.
In conclusion, this study demonstrates that OSAS surgery does not completely eliminate the disease in all patients and that CPAP therapy remains clinically relevant in the postoperative period. The addition of surgical treatment to CPAP therapy may provide beneficial effects on oxygenation and apnea burden in specific body positions, while it does not result in a significant change in CPAP pressure requirement. These findings support the concept that surgical and CPAP therapies should be considered complementary rather than mutually exclusive approaches in appropriately selected patients with OSAS.
Keywords: Obstructive sleep apnea syndrome, OSAS surgery, CPAP, Polysomnography, Oxygen saturation