Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)

  • HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
 

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Molar İnsizör Hipomineralizasyonundan Etkilenmiş Daimi Anterior Dişlere Uygulanan Direkt Veneer Restorasyonların Klinik Başarısının ve Ebeveyn Memnuniyetinin Değerlendirilmesi
(2026) Demirel Kardelen, Özgür Beste; Çocuk Diş Hekimliği
DEMIREL, K. Evaluation of Clinical Success of Composite Resin Restorations Applied Using Direct Veneer Templates for Lesions in Permanent Incisors Affected by Molar Incisor Hypomineralization (MIH). Hacettepe University Health Sciences Institute Specialty Thesis in Pediatric Dentistry, Ankara, 2026. This study aimed to evaluate the 12-month clinical performance of template-assisted direct composite resin restorations applied to permanent anterior teeth affected by molar incisor hypomineralization (MIH). A total of 80 teeth from 45 patients aged 7- 14 years, each presenting with at least one MIH-affected permanent anterior tooth with discoloration and opacity, were included. Composite restorations were placed without tooth preparation using a direct veneer template system. Tooth sensitivity was assessed using the Schiff Cold Air Sensitivity Scale (SCASS). Clinical performance was evaluated at baseline and at 3, 6, and 12 months using modified USPHS criteria. Parent-child satisfaction was assessed at the end of the follow-up period using a 5- point Likert scale. Statistically significant changes over time were observed in marginal adaptation, marginal discoloration, restoration fractures, and wear (p < 0.05). In contrast, no significant differences were found for color match, surface texture, or postoperative sensitivity (p > 0.05). Over the 12-month follow-up period, absolute failure was observed in two restorations (2.5%), both occuring at the 12-month evaluation. Both parents and children expressed high levels of satisfaction, with 95.6% giving combined ratings of 4 or 5 for the overall aesthetic results. Within the limitations of this study, template-assisted direct composite veneers demonstrated a low failure rate over 12 months and may represent a reliable, non-invasive treatment alternative for managing anterior MIH lesions in children.
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İÇ MİMARLIK EĞİTİMİNDE GELENEKSEL TASARIMDAN DİJİTAL TASARIMA GEÇİŞ SÜRECİNDE; AKADEMİ SANAYİ ETKİLEŞİMİ
(Güzel Sanatlar Enstitüsü, 2026-10-26) Beytullah BEŞKAYA; İç Mimarlık ve Çevre Tasarımı
Digital technologies, gaining momentum since the late twentieth century, have transformed design tools, teaching processes, modes of representation, and professional competencies in interior architecture education. This thesis examines the transition from traditional design approaches to digital design approaches in interior architecture education in relation to educational structure and professional practice. It examines how this transition is reflected in curriculum structure, course contents, the integration of digital design tools into teaching processes, graduate competencies, and sectoral expectations. The research is limited to selected universities in Türkiye offering interior architecture education where academy–industry interaction can be observed. Adopting a qualitative research approach, the study is based on a multi-stakeholder structure consisting of 42 students, 9 academics, and 10 sector representatives. Participants were determined through purposive sampling, and data were collected through semi-structured interviews. The data were analyzed through thematic analysis and evaluated in relation to digital design competencies, problem solving, academy–industry interaction, curriculum alignment, sectoral dynamics, and future technologies. The findings reveal that traditional and digital design approaches are not alternatives to one another, but complementary pedagogical components that should be considered together in interior architecture education. The results indicate a level of alignment in basic digital tools; however, partial alignment and gap areas persist regarding advanced technologies, practical experience, graduate competencies, and academy–industry interaction. In this respect, the study offers an original, multi-stakeholder, and holistic framework for evaluating the transition from traditional to digital design in interior architecture education through academy–industry interaction, curriculum, competencies, and professional expectations.
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TASARIM EĞİTİMİNDE MEKÂN, DONATI VE MOBİLYA KAPSAMINDAKİ ENDÜSTRİYEL İŞ BİRLİKLERİNİN İNCELENMESİ
(Güzel Sanatlar Enstitüsü, 2026) Eren Yünür; İç Mimarlık ve Çevre Tasarımı
The relationship between design education and industry has carried the imprint of social and economic transformation since the guild tradition. Each major rupture has reconstituted this relationship; education has first lagged behind, then found a new form. The transformation underway today marks a new link in the same cycle, and education is once again in search of a response. Understanding where Türkiye stands at this threshold is essential both for reading local dynamics and for anticipating what lies ahead. The study examines university–industry collaborations in Türkiye through the scales of space, equipment, and furniture, extending equipment to products that include industrial and digital objects. These three scales constitute the intersection of interior architecture and industrial design; the boundaries between the two disciplines blur at these scales. Tracing this ambiguity, the research addresses both disciplines together. A qualitative approach was adopted; fifteen semi-structured interviews were conducted with academics, industry representatives, and practitioners from intermediary institutions with collaboration experience across these scales. Data were analysed through thematic analysis, and the findings were interpreted against international institutional examples. The research reveals that Türkiye has largely adopted education models from abroad, and that the new collaboration mechanisms emerging internationally have not yet found full resonance locally. Existing contributions rest not on institutional frameworks but on individual or pioneering institutional initiative. It is concluded that design studio courses should become visible as a site of knowledge production within innovation mechanisms. The study offers forward-looking projections by tracking Türkiye alongside global transformation.
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BİFOSFONAT KULLANAN HASTALARDA İLACA BAĞLI OLARAK ÇENELERDE GÖRÜLEN OSTEONEKROZUN ETYOPATOGENEZİNDE OTOFAJİ, APOPTOZ VE NEKROZUN ROLÜ
(Sağlık Bilimleri Enstitüsü, 2026-09-10) Sena Aksoy Taçyıldız; Nuray Bayrakçı; Ağız Diş ve Çene Cerrahisi
Medication-related osteonecrosis of the jaw (MRONJ) is a multifactorial disease involving inflammation, cellular stress, and various cell death mechanisms, in addition to suppressed bone turnover. This study aimed to compare the protein and gene expression levels of Caspase-3, Beclin-1, and MLKL in saliva and gingival tissue samples from patients with bisphosphonate-related MRONJ and healthy controls. This cross-sectional, controlled, analytical study included 17 patients with MRONJ and 15 systemically healthy controls. Saliva and gingival tissue samples were obtained from all participants. Protein levels were measured using enzyme-linked immunosorbent assays, while CASP3, BECN1, and MLKL gene expression levels were evaluated using quantitative real-time polymerase chain reaction. Inflammation in gingival tissue was scored semiquantitatively, while additional histomorphological features were assessed descriptively. Caspase-3, Beclin-1, and MLKL protein levels were significantly higher in the MRONJ group in both saliva and gingival tissue, and these differences remained significant after adjustment for multiple comparisons (all p<0.001). At the gene expression level, only salivary MLKL expression was significantly increased in the MRONJ group, with a 3.01-fold change (adjusted p=0.027). No significant between-group differences were observed in salivary CASP3 or BECN1 expression or in the expression of any of the three genes in gingival tissue. Histopathological inflammation scores were significantly higher in the MRONJ group (p=0.042). Additional epithelial, connective tissue, vascular, microbial, and cell-death-related histomorphological findings showed heterogeneous distributions and were interpreted descriptively. No significant associations were found between biomarker levels and disease stage, history of zoledronic acid-containing treatment, or duration of antiresorptive therapy. These findings indicate that MRONJ is associated with a biomarker profile reflecting cellular stress and cell death, particularly at the protein level. Although saliva offers the advantage of non-invasive collection, these biomarkers require validation in larger, independent patient cohorts before they can be considered for clinical use.
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PROSTAT KANSERİNDE SİSTEMİK TEDAVİ YANIT DEĞERLENDİRİLMESİNDE Ga-68 İŞARETLİ PSMA PET-BT İLE BİYOKİMYASAL BELİRTEÇLERİN ROLÜ VE PROGNOSTİK ÖNEMİ
(Tıp Fakültesi, 2026) Oğuz Kodaz; Nükleer Tıp
Kodaz O. The Role and Prognostic Significance of Ga-68 Labeled PSMA PET/CT and Biochemical Markers in the Assessment of Systemic Treatment Response in Prostate Cancer, Hacettepe University Faculty of Medicine, Department of Nuclear Medicine, Thesis of Residency, Ankara, 2026. Prostate cancer is the second most common cancer in men, and accurate assessment of treatment response in the metastatic stage is critically important for patient management. Although serum prostate-specific antigen (PSA) is the principal biomarker for monitoring treatment response, it may be limited in reflecting the true tumor burden, particularly in the castration-resistant stage. Ga-68 labeled PSMA PET/CT, on the other hand, is a powerful imaging modality capable of demonstrating tumor burden at the volumetric and molecular levels. The aim of this study is to determine the role of PSMA PET/CT and biochemical markers such as serum PSA in the assessment of response to chemotherapy and radionuclide therapy in metastatic prostate cancer, the relationship of these parameters with one another, and their prognostic significance. This retrospectively designed study included three patient groups: patients with de-novo metastatic hormone-sensitive prostate cancer (mHSPC) receiving androgen deprivation therapy and docetaxel (Group A, n=49); patients with metastatic castration-resistant prostate cancer (mCRPC) receiving docetaxel chemotherapy (Group B, n=26); and patients with mCRPC receiving 177Lu-PSMA radionuclide therapy (Group C, n=96). In all cases, semiquantitative parameters obtained from pre- and post-treatment PSMA PET/CT, primarily total tumor volume (TTV), and serum PSA levels were recorded; treatment response was evaluated using the RECIP 1.0, PSMA PET Progression (PPP), and PCWG3/PCWG4 criteria together with serum PSA response criteria. The agreement (concordance-discordance) between imaging response and PSA response and the relationship of these parameters with overall survival were investigated. Our findings demonstrated that in the hormone-sensitive stage, in which the disease is highly responsive to treatment, there was a high degree of concordance between serum PSA changes and PSMA PET parameters, with discordance remaining low. However, as the disease progressed to the castration-resistant stage, this agreement was markedly disrupted; this suggested that tumor biology changes in mCRPC cases and that PSA may be insufficient to reflect the true tumor burden. In patients with discordance, PSMA PET response was found to be determinant for survival. A positive correlation between PSA and TTV changes was observed in patients receiving systemic therapy, particularly in the group receiving radionuclide therapy. PSMA PET-based response criteria that jointly consider volumetric change or the development of new lesions were found to provide more comprehensive information compared with assessments based solely on clinical and PSA data. In conclusion, particularly in the mCRPC stage, routinely evaluating PSMA PET/CT before making PSA-based treatment-change decisions is important for excluding pseudoprogression and for detecting early relapse before PSA progression develops. These retrospective findings need to be supported by multicenter and prospective studies involving larger patient cohorts.