Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
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Recent Submissions
A Proposed Onlıne Professıonal Development (Opd) Program For Novıce Efl Teachers
(Eğitim Bilimleri Enstitüsü, 2025) Akçor, Gizem; Yabancı Diller Eğitimi
This study aimed to design, implement, and evaluate a context-specific online professional
development (OPD) program tailored for novice teachers of English as a Foreign Language
(NEFLTs) in Türkiye. Grounded in adult learning theory—particularly self-directed and
transformative learning—the research employed a qualitative action research methodology
supported by descriptive statistics. A needs analysis involving 109 participants, including
novice and experienced EFL teachers and teacher educators, informed the development of
a five-module asynchronous OPD program. Designed based on the ADDIE instructional
model, the program was implemented through the Canvas learning platform. Module topics
included teacher well-being, classroom management, materials development, diversity in
the EFL classroom, and reflective teaching. The CIPP model guided program evaluation.
Data collection tools included questionnaires, KWL charts, self-reflective journals,
evaluation forms, and semi-structured interviews. Findings showed that the OPD program
effectively addressed NEFLTs’ professional development (PD) needs. Participants reported
improvements in theoretical knowledge, teaching skills, self-efficacy, and professional
identity. They valued the program’s structure, relevance, and reflective focus. Technology
and AI integration boosted digital skills and adaptability, while emphasis on inclusivity
enhanced responsiveness to diverse learners. The program also fostered emotional
resilience and personal growth. Noted challenges included time constraints, dense content,
and limited interactivity. Recommendations included incorporating live sessions, scaffolding
complex topics, and encouraging collaboration. Overall, the study highlights the importance
of needs-based, flexible, and reflective OPD in supporting the growth of NEFLTs in the
Turkish context.
Türk Diplomatik Arşiv Belgeleri Işığında İspanya İç Savaşı ve Türkiye-İspanya İlişkileri (1936-1939)
(Atatürk İlkeleri ve İnkılap Tarihi Enstitüsü, 2026) ÇETİNEL, Nihat; Atatürk İlke ve İnkılapları Tarihi
This study investigates the effects of the Spanish Civil War (1936-1939) on the political relations between Turkey and Spain. During this time, Turkey, aligned with Britain and France against revisionism, revisited unresolved issues from the Treaty of Lausanne, notably concerning the Turkish Straits and Hatay. The research analyzes developments followed closely by Turkey and other European nations, alongside their influence on Turkey’s policies and national politics, employing recently accessible documents from the Turkish Diplomatic Archive and Republican Archives. The study addresses limitations such as incomplete classification and missing correspondence, and utilizes a range of sources, including newspapers and official publications, to provide a comprehensive analysis of Turkey-Spain relations during the Civil War. Key incidents, such as tensions related to refugees and the embassy raid in Madrid, are highlighted to illustrate the underlying tensions between the two countries. These documents demonstrate that Turkey’s stance towards the Civil War was not shaped solely by its relations with major powers, but was also affected by problems arising in bilateral relations. During the Spanish Civil War, Turkey faced challenges due to piracy in the Mediterranean despite its sovereignty over the Turkish Straits established by the Montreux Convention. Consequently, Turkey was among the first nations to engage in the Nyon Conference aimed at curbing piracy. The conference improved Turkey's ties with Britain and France but caused a rift between Mustafa Kemal Atatürk and İsmet İnönü over their disagreements. The König incident involved fighter planes fraudulently ordered for Turkey sent to the Republicans. Meanwhile, the transfer of 712 refugees from the Turkish Legation in Madrid to Turkey, followed by their escape and return to Spain, strained relations with the Spanish government, impacting trade and leading to a loss of income from Turkey's egg exports to Spain.
Hematopoetik Hastalıklarla İlişkili Monoklonal İmmunoglobulin Birikimli Böbrek Hastalıklarının Klinikopatolojik Korelasyonu
(2026-01) Zehranur Kiki; Tıbbi Patoloji
Kiki Z., “Clinicopathological Correlation of Renal Diseases with Monoclonal Immunoglobulin Deposition Associated with Hematopoietic Disorders,” Hacettepe University Faculty of Medicine, Department of Medical Pathology, Residency Thesis, Ankara, 2026. Renal diseases associated with monoclonal immunoglobulin/paraprotein deposition are heterogeneous, and diagnostic classification and treatment decisions—particularly within the MGRS spectrum—can be challenging. This study aimed to characterize the morphologic spectrum of monoclonal gammopathy–associated renal lesions, evaluate the relationship between complement deposition on immunofluorescence (especially C3) and diagnostic patterns/clinical course, and explore its potential contribution to treatment strategy. A total of 104 kidney needle biopsies from 102 patients (2014–2024) were retrospectively reviewed; histology/histochemistry and immunofluorescence (IgG/IgA/IgM, C3, C1q, kappa/lambda) were re-evaluated, clinical data were retrieved, and appropriate statistical tests were used. The most frequent diagnostic pattern was PGNMIg (n=35, 33.7%). Complement deposition was identified in 46 of 104 biopsies (44.2%) and was most frequent in PGNMIg (71.4%) and MIDD (53.3%), while less common in light chain amyloidosis (16%). The association between treatment and renal course differed by C3 status: among C3-negative cases (n=26), progressive course was observed in 83.3% of patients treated with classical immunosuppressive/immunomodulatory agents versus 20.0% of patients treated with clone-directed therapy, with a significant difference (Mann–Whitney U p=0.018). In contrast, no significant difference was found in the C3-positive group (n=29; p=0.582). Overall, C3 deposition appears enriched in specific patterns (PGNMIg, MIDD) and, in this cohort, the benefit of clone-directed therapy on renal functional decline was mainly evident in C3-negative cases, suggesting C3 status may help individualize treatment strategies.
EK RİSK FAKTÖRÜ OLMAYAN GENÇ KADIN DEMİR EKSİKLİĞİ OLGULARINDA MENSTRÜEL KANAMA ÖZELLİKLERİNİN İNCELENMESİ
(Tıp Fakültesi, 2025-12-31) GİRİT ASYA; İç Hastalıkları
Girit, A. Examination of Menstrual Bleeding Characteristics in Young Female
Iron Deficiency Cases Without Additional Risk Factors. Hacettepe University
Department of Internal Medicine, Thesis in Internal Medicine Specialty,
Ankara – Türkiye, 2025.
Objective: Examination of menstrual bleeding characteristics in women with iron
deficiency or iron deficiency anemia, whose etiology was associated with menstrual
bleeding since there were no other identifiable risk factors.
Materials and Methods: 315 patients with iron deficiency anemia and 77 patients
with iron deficiency, who were admitted to the Hacettepe University Faculty of
Medicine Hospital Hematology Department between 2011 and 2025, and whose
menstrual bleeding characteristics were questioned in a standard way, were included
in the study. The clinical characteristics, laboratory values, and medical history of the
patients were evaluated retrospectively.
Results: Women with iron deficiency anemia and those with isolated iron deficiency
showed similar characteristics in terms of age, duration of menstrual bleeding,
number of heavy bleeding days, cycle length, number of sanitary pads used, and the
presence of large clots or jelly-like bleeding. When both groups were analyzed
together, the median duration of menstruation was 7 days. Bleeding lasting longer
than 6 days was observed in 69.9% of the patients. The presence of large clots or
jelly-like bleeding was reported in 88.5% of cases. Nearly all patients (96.1%) had a
history of menstrual bleeding longer than 6 days and/or bleeding with large clots
and/or jelly-like consistency.
Conclusion: Menstrual bleeding characteristics represent an important component
that may contribute to the clinical evaluation of iron deficiency. This study highlights
the importance of systematically assessing menstrual bleeding characteristics during
the diagnostic process.
Yaşlı Bireylerde Farklı Formüllerle Hesaplanan Glomerüler Filtrasyon Hızı İle Kognitif Fonksiyonların İlişkisi
(Tıp Fakültesi, 2025-11-14) Ceyhan Fahri; İç Hastalıkları
Ceyhan, F., The Relationship Between Glomerular Filtration Rate Calculated by Different Formulas and Cognitive Functions in Older Adults; Hacettepe University Faculty of Medicine, Department of Internal Medicine, Specialty Thesis; Ankara, 2025. The prevalence of cognitive impairment and chronic kidney disease (CKD) increases in older adults. The aim of this study was to investigate whether there is an association between cognitive impairment and CKD in older individuals and, if such a relationship exists, to determine which glomerular filtration rate (GFR) formula provides the most accurate clinical prediction. This study included 299 patients aged 65 years and older who were admitted to Geriatric Medicine Outpatient Clinic of Hacettepe University Faculty. Patients who had undergone both the Standardized Mini-Mental State Examination (S-MMSE) and the Quick Mild Cognitive Impairment–TR (QMCI-TR) tests during their routine visits were enrolled. GFR was calculated using creatinine-based formulas including FAS (Full Age Spectrum), BIS1 (Berlin Initiative Study 1), CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration), and MDRD (Modification of Diet in Renal Disease). The relationship between the patients’ cognitive test results and their GFR values was then analyzed. Participants’ ages ranged from 65 to 91 years, with a median age of 75. Of the participants, 55.9% were female. According to the Standardized Mini-Mental State Examination, cognitive impairment was observed in 33.1% (n=99) of participants, while QMCI-TR identified cognitive impairment in 33.8% (n=101). In the early stages of CKD, the combination of the FAS formula and S-MMSE provided a more sensitive approach for general cognitive screening. However, in patients with frailty or malnutrition, the combination of MDRD or BIS1 formulas with QMCI-TR was found to be more effective in detecting cognitive impairment associated with underlying geriatric syndromes. Based on these findings, early screening for cognitive impairment may enable detection in the preclinical or early stages of cognitive decline.