Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Communities in DSpace
Select a community to browse its collections.
- Ankara State Conservatory
- Directorates
- Faculty of Dentistry
- Faculty of Pharmacy
- Faculty of Letters
Recent Submissions
Mevalonat Kinaz Eksikliğine Özgü Uyarılmış Pluripotent Kök Hücrelerden Türetilen Monositlerin Karakterizasyonu ve Hücre Göçünün Araştırılması
(Sağlık Bilimleri Enstitüsü, 2026) Başak Şen; Tıbbi Biyoloji
Systemic autoinflammatory diseases are a group of disorders characterized by excessive activation of the innate immune system and recurring attacks of multisystemic inflammation. Familial Mediterranean fever (FMF) and Mevalonate Kinase Deficiency - Hyperimmunoglobulin D Syndrome (MKD-HIDS) are two systemic autoinflammatory diseases that result in the activation the pyrin inflammasome through different mechanisms. In previous works it has been demonstrated that pyrin and its protein partners colocalize with the actin cytoskeleton, potentially playing a role in actin rearrangement during cell migration. Increased cell migration, observed in cells from FMF patients where pyrin inflammasome is activated, supports these findings and points towards a link between pyrin activation and inflammatory cell migration. In contrast, primary cells from MKD-HIDS displayed defective cell migration. Due to the rarity of these diseases and difficulty accessing primary cells from patients, there is need for alternative models for autoinflammatory diseases. In light of this knowledge, in this thesis, primary fibroblast cultures were established from skin biopsies of 3 FMF and 3 MKD-HIDS patients and 1 healthy control. These primary fibroblasts were used to generate induced pluripotent stem cells (iPSC) for each individual. The iPSC lines were shown to express pluripotency markers and capacity to differentiate into three germ layers in vitro. The characterized iPSC lines were then differentiated into monocytes and characterized by gene expression and surface marker expression. Later, these iPSC-derived monocytes were utilized for cell migration and experiments which demonstrated a MKD-specific gene migration defect
TÜRKİYE’DE BELEDİYELERE ÖZGÜ PERSONEL İSTİHDAM SİSTEMİ
(Sosyal Bilimler Enstitüsü, 2026-10-30) BURCU SEVİNÇ; Siyaset Bilimi ve Kamu Yönetimi
In Türkiye, the central government retains substantial authority over personnel employment in municipalities. It is widely recognized that enhancing municipal autonomy in matters such as the recruitment, appointment, reassignment, and dismissal of municipal personnel, while ensuring coordination with the central administration, can only be achieved through the establishment of a municipality-specific personnel employment system. Accordingly, this dissertation is based on the premise that the establishment of a personnel employment system designed exclusively for municipalities would constitute a significant step toward improving the effectiveness and efficiency of human resource management practices in local governments. The study employed a qualitative research design using semi-structured interviews as the primary data collection method. The research sample comprised three metropolitan municipalities selected from different geographical regions of Türkiye, together with two district municipalities from each metropolitan municipality based on population size; three provincial municipalities without metropolitan status from different geographicsl regions, together with two district municipalities and one town municipality from each province by taking into account objective criteria such as distance to the provincial center and population. Interviews were conducted with managers responsible for human resources in the selected municipalities. In addition, interviews were held with representatives from a central government institution, a trade union president, and a deputy trade union president. In total, 24 participants were included in the study. The findings indicate that establishing a municipality-specific personnel employment system would contribute to addressing persistent problems such as political influence in recruitment, favoritism, and the excessive reliance on personnel employed through municipal companies. Furthermore, the results of this research show that the proposed system is expected to facilitate the supervised implementation of the merit principle, thereby enabling municipalities to recruit more qualified personnel and enhance the quality of public service delivery while improving institutional standards. Consequently, the findings confirm the principal hypothesis of this thesis that “the centrally designed and implemented personnel employment system is insufficient to meet municipalities’ needs for recruiting qualified personnel that adequately correspond to their institutional requirements”. Accordingly, the study concludes that establishing “a municipality-specific personnel employment system” can represent a practical and beneficial approach to strengthening municipal human resource management.
Monsters, Martians and Machines: The Evolution of “The Other” Through the Nineteenth and Twentieth Century British Science Fiction
(Sosyal Bilimler Enstitüsü, 2026) Zehra Safa MAYİR; İngiliz Dili ve Edebiyatı
Science fiction has long been a fertile ground for reimagining what it means to be human by exploring what it means to be not human. In particular, British science fiction of the nineteenth and the twentieth centuries has served as a powerful narrative laboratory for representing and interrogating the concept of “the Other.” Across the span of approximately one hundred and fifty years, the figure of the Other in science fiction transforms—from bodily grotesquerie to imperial threats, and finally to disembodied yet intelligent systems. Through detailed analysis of Mary Shelley’s Frankenstein: Or the Modern Prometheus (1818), H.G. Wells’s The War of the Worlds (1898), and Arthur C. Clarke’s 2001: A Space Odyssey (1968), this study traces a progression from the bodily Other to the colonial Other, and finally to the posthuman Other. Each novel reflects its historical moment: Shelley’s creature embodies fears of scientific transgression and physical monstrosity; Wells’s Martians mirror imperialist ideologies and fears of reverse colonisation; and Clarke’s HAL 9000 personifies anxieties about artificial intelligence and the loss of human agency. Drawing on theoretical frameworks from monster theory, colonial studies, and posthumanism, the thesis demonstrates how the genre of science fiction participates in redefining the boundaries of the human by reimagining the figure of the Other across time. Ultimately, this study argues that British science fiction offers a unique lens through which to understand the shifting cultural constructions of otherness in modernity.
Şeffaf Plak Tekniğinde Ramus Plağı veya Bukkal Shelf Mini Vidası Kullanımının Mandibular Molar Distalizasyonuna Etkisinin FEM ile İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2026-09-16) Burak Şanlı; Ordodonti
ŞANLI, Burak. Investigation of the Effects of Ramus Plate or Buccal Shelf Miniscrew Use on Mandibular Molar Distalization with Clear Aligners Using FEM. Hacettepe University Faculty of Dentistry, Department of Orthodontics, Specialization Thesis, Ankara, 2026. This study compared the initial biomechanical responses of ramus plate, buccal shelf miniscrew, and Class III elastic mechanics combined with metal buttons or precision cuts during mandibular total arch distalization with clear aligners. Six finite element models were generated from the CBCT data of a Class III patient suitable for camouflage treatment. Forces of 300 gf and 170.1 gf were applied in the skeletal anchorage and Class III elastic models, respectively. Tooth displacements, periodontal ligament and clear aligner stresses, aligner deformation, anchorage responses, and surrounding bone stresses were evaluated. In all models, mandibular crowns displaced posteriorly and root apices anteriorly; distal tipping occurred in posterior teeth and lingual crown tipping in incisors. Molar posterior displacement was greatest in the ramus plate models, lower in the buccal shelf miniscrew models, and lowest in the Class III elastic models. In all models, total displacement was concentrated in the canine–first premolar region and decreased posteriorly. In the skeletal anchorage models, precision cuts reduced canine periodontal ligament stress, shifted the maximum stress to the first premolar, and increased clear aligner stress and deformation in the canine region. In the ramus plate models, stress increased toward the fixation region and displacement toward the free end, whereas peak stress in the buccal shelf miniscrew models occurred at the screw head–threaded body transition. Principal stresses around the anchorage components were greater in cortical than trabecular bone. The findings indicate that the initial biomechanics are influenced by the anchorage system, force magnitude and direction, and force-transfer method.
Monsters, Martians and Machines: The Evolution of “The Other” Through the Nineteenth and Twentieth Century British Science Fiction
(Sosyal Bilimler Enstitüsü, 2026) Zehra Safa MANGIRCIOĞLU; İngiliz Dili ve Edebiyatı
Science fiction has long been a fertile ground for reimagining what it means to be human by exploring what it means to be not human. In particular, British science fiction of the nineteenth and the twentieth centuries has served as a powerful narrative laboratory for representing and interrogating the concept of “the Other.” Across the span of approximately one hundred and fifty years, the figure of the Other in science fiction transforms—from bodily grotesquerie to imperial threats, and finally to disembodied yet intelligent systems. Through detailed analysis of Mary Shelley’s Frankenstein: Or the Modern Prometheus (1818), H.G. Wells’s The War of the Worlds (1898), and Arthur C. Clarke’s 2001: A Space Odyssey (1968), this study traces a progression from the bodily Other to the colonial Other, and finally to the posthuman Other. Each novel reflects its historical moment: Shelley’s creature embodies fears of scientific transgression and physical monstrosity; Wells’s Martians mirror imperialist ideologies and fears of reverse colonisation; and Clarke’s HAL 9000 personifies anxieties about artificial intelligence and the loss of human agency. Drawing on theoretical frameworks from monster theory, colonial studies, and posthumanism, the thesis demonstrates how the genre of science fiction participates in redefining the boundaries of the human by reimagining the figure of the Other across time. Ultimately, this study argues that British science fiction offers a unique lens through which to understand the shifting cultural constructions of otherness in modernity.