Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
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Malik Aksel'in Resim ve Yazılarında Türk Halk Kültürü
(Sosyal Bilimler Enstitüsü, 2026-06-22) DEMİREL ŞEKERCAN CEREN; Türk Halkbilimi
Malik Vicdani Aksel (1901-1987) was a multifaceted figure in Turkish cultural and artistic life, encompassing painters, educators, writers, and collectors. Having witnessed the final years of the Ottoman Empire and the early decades of the Republic of Türkiye, Aksel documented numerous elements of folk culture through his writings, paintings, and collecting activities. Regarded as one of the pioneering figures in studies focusing on the visual dimension of folk culture in Türkiye, Aksel drew attention with his works on folk painting, religious imagery, calligraphic pictures, as well as his writings on Istanbul and his paintings that took folklore as their central theme. However, studies on Malik Aksel have largely focused on art history and fine arts, and he has not been the subject of a comprehensive and independent examination within the discipline of folklore. This study aims to reveal Malik Aksel’s place within folklore and to evaluate his contributions to Turkish folk culture from a folkloric perspective. The primary material for this research consists of Malik Aksel’s books, articles published in various newspapers and magazines, his paintings, and his collecting activities. This study utilized document analysis, a qualitative research method, and the data obtained were evaluated using content analysis. The research examined Aksel’s views on folk art; his definition, sources, creators, aesthetic characteristics, and functions of folk art were discussed. Furthermore, activities aimed at collecting, preserving, and transmitting folk art to future generations were evaluated, and the importance of these efforts for folk culture was highlighted. Another axis of the study, within the context of Istanbul folklore, examined data related to folk architecture, traditional professions, entertainment life, ceremonies, folk theater, and daily life found in Aksel’s works. Thus, it was demonstrated that Malik Aksel was not only a painter and writer, but also an important folklore researcher who recorded, interpreted, and contributed to the preservation of national culture through oral, written, and visual dimensions of folk culture.
Anadolu'da Telgrafın Toplumsal Tarihi (1856-1908)
(Sosyal Bilimler Enstitüsü, 2026-06-23) Mahir Melih GÜNEŞ; Tarih
This thesis examines the role of the Anatolian population in the development and use of the telegraph in Anatolia between 1856 and 1908. Moving away from the traditional bureaucracy-centred narrative, the thesis argues that the telegraph was not simply an instrument serving central government in its attempts to strengthen its hold over society, as is often argued, but that, on the contrary, it provided the Anatolian population with an instrument with which to expose and to complain about the failings of local administrations to the central government.
The development of telegraphy in Anatolia began with a series of projects launched by British entrepreneurs at the end of the Crimean War of 1853-1856, as a part of the British intercontinental telegraph project to connect London and Bombay. The construction of telegraph lines throughout the entire Tanzimat period (1839-1876) and the reign of Abdülhamid II (1876-1909) was based on the project created by these British initiatives. Viewed as a necessity by foreign entrepreneurs and as an economic burden by the Ottoman government, the spread of the telegraph in Anatolia was largely shaped by and the costs borne by the Anatolian population. Throughout the 1860s, the Ottoman central government supported the expansion of the telegraphic network, provided that the public covered infrastructural costs. The enthusiastic adoption of the telegraph by the Anatolian population gradually set state and society against each other as the population’s use of the telegraph uncovered an administrative crisis in Anatolia, highlighting the failures of the Tanzimat and Islahat reforms. During the Hamidian Era, aware of the dangers posed by the telegraph, the regime tried to keep the telegraph under its control to prevent opposition and the dissemination of discontent. Nevertheless, controlling the telegraph did not mean controlling society. Consequently, throughout this period, administrative problems continued to emerge via the telegraph system and ultimately the telegraph became instrumental in bringing about the end of the Hamidian regime in 1908.
6 Şubat 2023 Depremleri Tarafından İslahiye–Fevzipaşa Çevresinde Tetiklenen Kaya Düşmelerinin Yüksek Çözünürlüklü Ortofotolar Kullanılarak Değerlendirilmesi
(Fen Bilimleri Enstitüsü, 2026-03-12) Minagul Habibi; Jeoloji Mühendisliği
On February 6, 2023, two large earthquakes with magnitudes of 7.7 and 7.6 occurred approximately 9 hours apart. During these earthquakes, numerous rockfalls were triggered, particularly in mountainous regions; these rockfalls caused significant damage and loss of life in both transportation routes and residential areas. One area where rockfalls were particularly intense is the mountainous region surrounding the İslâhiye and Fevzipaşa of Gaziantep province. Rockfalls in this region led to the complete closure of the railway route. This thesis aims to create an inventory of rockfalls triggered by the February 6, 2023 Kahramanmaraş earthquakes in a region between İslâhiye and Fevzipaşa within the Gaziantep province and to apply rockfall analyses. Understanding the mechanisms of slope movements and evaluating the potential future hazards requires detailed inventory studies. However, creating an inventory of rockfalls solely through field studies is often not possible. Since rock blocks falling onto transportation routes are quickly cleared, determining the final stopping points of falling rock blocks becomes difficult. Following the earthquake, high-resolution orthophotos of the earthquake zone were produced as a result of flights conducted in the region by the General Directorate of Mapping. These high-resolution orthophotos provide an effective data source for determining the locations, sizes, and effects of rockfalls. Therefore, within the scope of this study, data was collected using high-resolution orthophotos such as satellite images, aerial photographs, and special shots, the spatial distribution of rockfalls triggered by earthquakes in the study area was determined, and a detailed inventory of the effects of these events was created, and analyses of rock blocks whose locations are known were performed. The inventory prepared will constitute an important data source and foundation for detailed analyses to be applied in the future.
Ekstrakte Edilemeyen Tıbbi Cihazların Sitotoksisite ve İrritasyon Potansiyellerinin Alternatif Doku Modelleri ile Araştırılması
(Sağlık Bilimleri Enstitüsü, 2026-06-05) Gümüş, Betülay; Farmasötik Toksikoloji
Biocompatibility assessment is a critical step in ensuring the safe placement of medical devices on the market. Cytotoxicity, irritation, and sensitization are among the fundamental biological risks that must be evaluated for all medical devices. Animal testing, which has long been widely used for the assessment of these risks, is increasingly being replaced by alternative in vitro methods due to ethical concerns, high costs, time requirements, and issues related to standardization. The limited availability of data on the in vitro evaluation of medical devices in liquid, gel, particulate, and cream forms—which are particularly difficult or impossible to extract—makes research in this area particularly important. In this thesis, the cytotoxicity and irritation potential of non-extractable medical device samples belonging to different risk classes were evaluated using alternative in vitro methods. Cytotoxicity assessments were performed using the MTT assay in 3T3 cell cultures, while irritation potential was evaluated using a Reconstructed Human Epidermis (RhE) model in accordance with OECD Test Guideline 439. In addition, TNF-α, IL-2, IL-4, IL-6, and IL-8 levels were analyzed in RhE tissue culture media by ELISA to provide a more comprehensive evaluation of the irritation response. The cytotoxicity studies demonstrated concentration-dependent cellular responses to the tested medical device samples. While some samples exhibited cytotoxic effects at higher concentrations, they significantly increased cell viability at lower concentrations. Irritation testing using the RhE model revealed that none of the investigated medical devices were classified as irritants. Cytokine analyses showed that TNF-α, IL-2, IL-4, IL-6, and IL-8 levels were significantly elevated compared with the negative control group, while remaining lower than those observed in the positive control group. The findings indicate that cell culture systems and three-dimensional human epidermis models represent applicable and reliable alternative approaches for the biocompatibility assessment of non-extractable medical devices without the need for extraction procedures. Furthermore, cytokine analysis was shown to provide additional information beyond conventional cell viability measurements, enabling a more comprehensive characterization of biological responses induced by medical device materials. Overall, this study contributes to the scientific literature by providing data supporting the use of alternative in vitro approaches in the biocompatibility evaluation of non-extractable medical devices.
YENİ İBUPROFEN/1,2,4-TRİAZOL HİBRİTLERİNİN TASARIMI, SENTEZİ VE COX İNHİBİTÖR AKTİVİTE İLE ANTİPROLİFERATİF ETKİLERİNİN DEĞERLENDİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2026-06-05) Balaban, Aylin; Farmasötik Kimya
In this study, a total of 26 novel hybrid compounds with the structure of 2-[(3-(1-(4-isobutylphenyl)ethyl)-1,2,4-triazol-5-yl)thio]-N-(substituted phenyl)acetamide were synthesized using the molecular hybridization approach. The melting points of the target compounds were determined, and their structures were elucidated using IR, 1H-NMR, 13C-NMR, HSQC, and HRMS spectral analysis techniques. The cyclooxygenase enzyme inhibition activities of the compounds were evaluated in vitro, and the results were compared with those of the reference compounds ibuprofen (COX-2/IC50 = 5,326 ± 0,218 μM), celecoxib (COX-2/IC50 = 0,132 ± 0,005 μM) and nimesulide (COX-2/IC50 = 1,684 ± 0,079 μM). Compounds 5a5 (2-NO2, IC50 = 1,921 ± 0,086 μM), 5a14 (4-OCH3, IC50 = 0,240 ± 0,010 μM), 5a15 (4-Cl, IC50 = 2,881 ± 0,136 μM), 5a16 (4-NO2, IC50 = 0,169 ± 0,007 μM) and 5a26 (2,5-OCH3-4-NO2, IC50 = 0,326 ± 0,014 μM) were found to exhibit remarkable COX-2 inhibitory activity. In addition, compounds 5a5 (selectivity index >100) and 5a15 (selectivity index >100) demonstrated strong selectivity profiles toward the COX-2 enzyme. Furthermore, the antiproliferative activities of the target compounds were evaluated by the MTT assay using MCF-7, HT29, HepG2, C6, and NIH3T3 cell lines. The obtained results revealed that compounds 5a5, 5a15, and 5a26 exhibited cytotoxic activities comparable to doxorubicin in cancer cell lines, while showing lower cytotoxicity against the healthy NIH3T3 cell line. Notably, the significant antiproliferative effects of these selective COX-2 inhibitory compounds
against various cancer cell lines suggest that these structures may be considered promising dual-acting candidate molecules possessing both antiinflammatory and anticancer properties.