Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
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Gastronomik Mirasın Tanıtımında Grafik Tasarımın Rolü ve Bir Uygulama
(Güzel Sanatlar Enstitüsü, 2026-10-14) Zeynep Helin DEMİRER; Grafik
Tank to developing technologies, information can be easily accessed through social media. Graphic design, as one of the tools of visual communication, is an important discipline for the promotion and preservation of cultural heritage. It enables societies to convey their historical, artistic, and gastronomic heritage to wider audiences. Through the opportunities provided by traditional and digital media, graphic design creates a lasting impact by blending cultural values with a modern design approach.
This study aims to promote and preserve gastronomic heritage through graphic design disciplines by creating original beverages using ingredients produced in Türkiye and frequently used in Turkish cuisine. Within the scope of the research, the effects of packaging design, book design, corporate identity design, and social media were examined in the context of graphic design. Within the framework of Türkiye’s gastronomic heritage, the study aims to design a beverage book in which traditional beverages are combined with modern mixology and graphic design disciplines.
In the first section of the thesis, which consists of four chapters, gastronomy and food culture throughout the history of Türkiye were examined. Concepts such as gastronomy, gastronomic culture, and gastronomic heritage were analysed. Studies conducted in the world and in Türkiye for the preservation of gastronomic heritage were researched and presented.
In the second section of the study, the concept of graphic design was examined through gastronomy. The common points between the disciplines of graphic design and gastronomy were investigated. Examples of fields such as packaging design, corporate identity design, and social media were analysed within the context of graphic design.
In the third section of the study, the areas where gastronomic culture intersects with graphic design were explored. In addition to the literature review conducted for the beverage book in the practical section, significant examples were examined within the context of graphic design.
In the fourth section of the study, new beverage recipes were created in line with the information obtained from the previous chapters and the analyses conducted. A beverage book containing these recipes was designed.
OPTIMIZATION OF SEGMENTAL TUNNEL LININGS: A PARAMETRIC STUDY ON THE EFFECTS OF GSI AND OVERBURDEN DEPTH
(2026-10) Cemre Çağlar; İnşaat Mühendisliği
In mechanized tunneling using Tunnel Boring Machines (TBMs), accommodating severe geostatic loading typically requires increasing the thickness of precast concrete segmental linings, which introduces critical logistical constraints, elevates excavation volumes, and increases overall material consumption. To address these engineering challenges, this thesis presents a comprehensive numerical investigation into an alternative support strategy that couples thin precast concrete segments with internal, high-stiffness structural steel rings installed in an alternating sequence. Three-dimensional finite element simulations were conducted using PLAXIS 3D to capture the multi-axial ground-structure interaction and staged excavation dynamics of mechanized shield tunneling, employing the elastoplastic Hoek-Brown failure criterion for the surrounding rock mass. The system was evaluated in two main directions: (a) variation of the Geological Strength Index (GSI) with a constant depth and (b) variation of the operating overburden depth with uniform ground conditions, using a complete parametric framework. The structural response was systematically analyzed by means of key performance indicators such as total displacements, hoop thrust forces, in-plane shear forces, in-plane bending moments, as well as secondary longitudinal and outof-plane internal forces. The numerical results demonstrate that the alternating i stiffness configuration activates an active load-redistribution mechanism along the tunnel drive; the structural steel rings of high stiffness receive disproportionately higher axial forces and flexural demands, thus shielding the neighboring thin concrete segments from localized stress concentrations and eccentric loading. The longitudinal force profiles show a typical periodic variation with demand maxima at the locations of the steel ring and a significant relief in the zones of the intermediate concrete segment. Internal force magnitude is strongly dependent on rock mass competence and a better ground quality triggered by mobilization of an effective natural ground arch leads to a sharp reduction of structural bending demands. Rather, an increase in overburden depth will raise the cross-sectional thrust and sidewall bending actions. However, the structural utilization levels of all components were observed to remain within the allowable limit state thresholds under the investigated conditions. To summarize, the study demonstrates the potential applicability of internal steel rings to significantly reduce the lining thickness compared to conventional solutions, and provides a structurally stable, logistically feasible and material-efficient alternative for deep mechanized tunneling in challenging geological conditions.
SODYUM GLUKOZ KOTRANSPORTERİ-2 İNHİBİTÖRLERİNİN ALZHEİMER HASTALIĞI BENZERİ MODELDE NLRP3 İNFLAMAZOMU ARACILI NÖROİNFLAMASYON ÜZERİNE ETKİSİ
(Sağlık Bilimleri Enstitüsü, 2026) Mercan Buse Esra; Farmakoloji
Neuroinflammation, particularly microglial activation and NLRP3 inflammasome-mediated inflammatory responses, is an important component of Alzheimer’s disease (AD) pathogenesis. In addition to their glucose-lowering effects, sodium-glucose cotransporter-2 (SGLT-2) inhibitors have been shown to exert anti-inflammatory effects, which may be partly associated with suppression of the NLRP3 inflammasome. However, the effects of SGLT-2 inhibitors on NLRP3 inflammasome-related inflammatory responses under AD-like conditions have not yet been fully elucidated. In this study, the effects of bexagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and canagliflozin were evaluated in amyloid beta (Aβ)- and lipopolysaccharide (LPS)-induced BV2 microglial inflammation models using MTT, Griess, Western blot, and ELISA assays. In the Aβ model, bexagliflozin significantly reduced NLRP3, ASC, and caspase-1 protein levels as well as IL-1β and IL-18 levels, whereas dapagliflozin reduced NLRP3 and ASC protein levels and both cytokines. Ertugliflozin and canagliflozin showed more selective effects, while empagliflozin did not produce significant changes in the evaluated markers. In the LPS model, all five inhibitors significantly reduced NLRP3, ASC, IL-1β, and IL-18 levels, whereas caspase-1 was reduced only by bexagliflozin and empagliflozin. These findings support the further evaluation, particularly of bexagliflozin and dapagliflozin, in mechanistic and preclinical studies as potential pharmacological candidates targeting the NLRP3 axis in AH-associated neuroinflammation.
Devlet Konservatuvarlarında Klarnet Performans Değerlendirme Pratiklerinin İncelenmesi
(Güzel Sanatlar Enstitüsü, 2026) Elif Simay Meteoğlu; Üfleme ve Vurmalı Çalgılar
The purpose of this study is to examine the practices used in the assessment of clarinet performance at state conservatories in Turkey from the perspective of faculty members. Designed as a qualitative case study, the research's data sources consist of semi-structured interviews conducted with ten clarinet faculty members working at state conservatories in Istanbul, Ankara, Izmir, Eskişehir, Kocaeli, and Antalya. The findings indicate that most participating institutions lack a descriptive, multi-level, commonly used scoring tool (rubric), and that assessment largely relies on individual judgment and jury consensus. Scoring forms used in some institutions were found to function as general guidelines based on category headings and point ranges, rather than as rubrics as defined in the literature. Inter-rater consistency was relatively easy to achieve on technical criteria, whereas disagreements became more pronounced on artistic dimensions such as musical interpretation. Transparency toward students remained limited, and views on standardized assessment tools were divided between concern over restricting artistic flexibility and the expectation of improved objectivity. The study offers recommendations for developing an assessment tool that defines technical dimensions through descriptive levels and differentiates by educational level.
Yapay Zekâ Teknolojileri İle Gerçekleştirilen Tipografik Uygulamaların Görsel Göstergebilim Açısından İncelenmesi
(Güzel Sanatlar Enstitüsü, 2026) Maşallah Sincar; Grafik
This thesis examines typographic applications created using artificial intelligence technologies through the lens of visual semiotics and presents practical applications in this context; it focuses primarily on the study's core concepts: artificial intelligence, typography, and semiotics. The analysis and investigation are conducted on typographic designs generated using artificial intelligence tools a contemporary technology.
The study’s primary methodology consists of semiotic analyses based on qualitative research principles, while quantitative methods provide supporting data. In this context, the research sample comprises nine typographic works created using artificial intelligence, and a purposive sampling approach is used to examine these examples.
In the first chapter, the research subject and problem are defined to establish the conceptual framework; subsequently, the study’s purpose, significance, methodology and techniques, basic assumptions, hypotheses, limitations, the historical development of the subject, and similar studies in the field are addressed.
The second chapter explores various aspects of artificial intelligence and typography, discussing their interrelationships and characteristics. While the section titled "Artificial Intelligence" covers types of AI, AI technologies, and application areas, typographic design is evaluated under three main headings. The historical background of typography is summarized under "Classical/Traditional Typography," while the 20th century and beyond are examined under the headings "Typography in the Modernist Era" and "Typography in the Postmodernist Era."
The third chapter provides fundamental definitions regarding signs and semiotics and outlines semiotic theories and analytical approaches. Subsequently, drawing upon the information presented regarding semiotic analysis approaches, typographic applications created using artificial intelligence technologies are examined through the lens of visual semiotics.
In the fourth chapter, practical applications carried out using various artificial intelligence tools are analyzed and presented; the conclusion addresses the research process and the findings obtained, while also offering recommendations.