Biyomühendislik
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Osteokondral Hasarlar İçin Peptit Amfifil ve Bor Katkısı İçeren Gradyan Özellikli Kitosan Biyomürekkep Formülasyonlarının Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2024)Since the current methods for treating osteochondral damage are insufficient, there is a need to develop new treatment approaches. In this area, research is ongoing to develop alternative treatment methods using tissue ... -
Simvastatin için Kontrollü İlaç Salım Sisteminin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2024)In this study, poly(2-hydroxyethyl methacrylate-N-methacryloyl-L-tryptophan methyl ester) cryogel membranes were synthesized at different concentrations using the molecular imprinting technique (MIT) for controlled release ... -
Grafen/GelMA/PCL Sinir Konduit Benzeri Yapılarda Elektriksel Stimülasyon Altında Temel Hücre Etkileşiminin İncelenmesi
(Fen Bilimleri Enstitüsü, 2024)The frequency of peripheral nerve injuries, the consequences affecting living standards depending on the type and location of the injury, the difficulties encountered with traditional surgical treatment methods through ... -
Seramik Faz İçeren Yumuşak Doku Ogmentasyon Jellerinin Hazırlanması ve Karakterizasyonu
(Fen Bilimleri Enstitüsü, 2024-09-06)Various factors such as trauma, ultraviolet radiation, nutritional deficiencies, and aging can lead to tissue loss, atrophy of the skin and subcutaneous tissue, and connective tissue weakness, resulting in soft tissue-related ... -
Fotostimülasyonun 2 ve 3 Boyutlu in vitro Hiperglisemik Modellerde İnsan Dermal Fibroblast, Keratinosit ve Endotel Hücreleri Üzerindeki Etkinliğinin İncelenmesi
(Fen Bilimleri Enstitüsü, 2024)This study is supported by the Scientific Research Projects Coordination Unit (BAP) of Hacettepe University as part of the comprehensive research project titled "Investigation of the Effectiveness of Photostimulation in ... -
Investigation of The Effects of Perceptual Salience on Target Tracking Behavior Performance of Zebrafish During Rheotaxis
(Fen Bilimleri Enstitüsü, 2024-09-06)Zebrafish (Danio rerio) are freshwater fish inhabiting rivers and lakes in the South Asian region. During their behavior known as rheotaxis, they exhibit a tendency to orient their bodies againts the water flow, thereby ... -
Poli(Bütilenadipat-Ko-Tereftalat) (Pbat)-Bazlı Nanotopografik Fibröz Doku İskelelerinin Üretimi ve Hücresel Davranışların İncelenmesi
(Fen Bilimleri Enstitüsü, 2024)The aim of the study is to investigate the effects of poly(butylenadipate-co-terephthalate) (PBAT) based fibers and fibrous matrices with nanotopographic surface properties on the mechanotransduction mechanism and cell ... -
Telomeraz Aktivitesi Tayinine Yönelik Yüksek Enerji Dönüşümlü Floresan Partiküllerin Biyosensör Olarak Kullanımı
(Fen Bilimleri Enstitüsü, 2024)Within the scope of this thesis study, it is aimed to develop a descriptive fluorophore-probe that can detect telomerase from body fluid with silica nanoparticles by using the high energy up-conversion feature of rare earth ... -
Anjiyogenik Mikroiğnelerin Geliştirilmesi ve Karakterizasyonu
(Fen Bilimleri Enstitüsü, 2024)Angiogenesis plays a crucial role in tissue repair processes, ensuring the continuation of important cellular processes as stem cell differentiation, cell proliferation, and migration during tissue repair. It also plays a ... -
Rekombinant Antikor Fragmentlerinin Üretimi ve Genetik Modifikasyonuyla Sitokin Ölçümüne Yönelik İmmünoassay Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2024)Cytokines, which play an important role in the regulation of immune responses and inflammation, are used as biomarkers in the diagnosis of many diseases. During this immune response to pathogens or diseases, cytokine ... -
Lizozim Tayini İçin Lizozim Baskılanmış Yüzey Plazmon Rezonans Çipler
(Fen Bilimleri Enstitüsü, 2024-02-14)Lyzozyme, a natural antimicrobial defense mechanism in the body, acts by breaking down the cell walls of microorganisms and is found in various tissues. Due to this property, it is considered an important component ... -
Bor, Çinko, Magnezyum ve Kalsiyum İçeren Biyoaktif Seramik Tozların Akrilik Kemik Çimentosunun Isıl ve Mekanik Özelliklerine Etkilerinin İncelenmesi
(Fen Bilimleri Enstitüsü, 2024)Acrylic bone cements are a two-component system consisting of powder and liquid phase. It is frequently used in orthopedic surgery to provide prosthesis fixation. The paste-like mixture formed after mixing the powder ... -
Kontrollü Florid Salımı İçin Moleküler Baskılanmış Süpermakrogözenekli Kriyojellerin Hazırlanması
(Fen Bilimleri Enstitüsü, 2023-11-08)In this thesis, fluoride release from fluoride imprinted cryogel discs was carried out and different parameters were investigated in vitro. Cryogels are macroporous polymeric structures formed by cryojelation of ... -
Triyas-Jura Yaşlı Tabas Kömürlerinin Kimyasal Ve Petrografik Özellikleri, Orta İran
(Fen Bilimleri Enstitüsü, 2023)This thesis study aims to investigate the geochemical and petrographical properties of coals from the Parvadeh and Mazino coalfields in the Tabas Basin. This basin is in the Tabas Block of the Central Iran Region located ... -
Hasarlı Omurilik Onarımı İçin Hücre Destekli Enjekte Edilebilir İpek Fibroin Mikrotaşıyıcıların Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2023-09)According to the data of the World Health Organization (WHO), spinal cord injuries affect between 250,000 and 500,000 people every year. In current clinical practice, there is no treatment method that can completely ... -
Vezikovajinal Fistül Onarımı İçin Pro-Anjiogenik/Antibakteriyel Doku İnterpozisyon Flep Eşleniğinin Tasarımı ve Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2023-07)A vesicovaginal fistula (VVF) is an anbormal opening between the bladder and vagina that causes continous leakage of urine and urinary incontinence. Definitive treatment of VVF is surgery and the type of surgical intervention ... -
Sinir Doku İskelesi Olarak Modifiye Edilmiş Pedot:Pss ve Pedot:Heparin Kaplanmış Kanallar İçeren Pdms Temelli Esnek ve İletken Kompozit Filmlerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2023)Within the scope of this master's thesis, conductive and flexible films based on Poly (3,4-ethylene dioxide thiophene):Poly(styrene sulfonate) (PEDOT:PSS) and Poly (3,4-ethylene dioxidethiophene):Heparin (PEHE) were studied. ... -
Akne Tedavisi için İlaç Yüklü Mikroiğneli Yamaların Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2023)Acne vulgaris is a common and chronic disease, especially during adolescence, due to various factors such as inflammation of the pilosebaceous units of the skin, colonization of the Propionibacterium acnes bacterium, ... -
Yara İyileşmesine Yönelik Ekzozom Entegre Biyoaktif Jelatin Süngerlerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2023)Exosomes are intercellular signal transduction vesicles, that play a role in many biological processes such as angiogenesis, antigen transport, apoptosis, coagulation, cellular hemostasis, inflammation, and intercellular ... -
Kan Pıhtılaşma Faktörlerinden Faktör VIII'in Anjiyogeneze Pozitif Etkisinin Koriyoallantoyik Membran Modelinde Gösterilmesi
(Fen Bilimleri Enstitüsü, 2023)Tissue engineering has become an approach that is frequently used in the field of health along with many disciplines today. In vascular tissue engineering, which is one of these areas, substances that affect the vascular ...
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