Browsing Biyomühendislik by Title
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Adenozin Tayinine Yönelik Optik Temelli Nanosensörlerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2022-01)In this thesis, a novel measurement method is proposed to measure the level of adenosine nucleoside which is a significant molecule utilized as a direct or indirect indicator to detect diseases such as neurodegenerative ... -
Akciğer Havayolu Modellemesine Yönelik Oluşturulan Deselülerize Doku İskeleleri ile 3b Hücre Kültür Sistemlerinin Kurulması
(Fen Bilimleri Enstitüsü, 2021)The lungs have the task of providing the necessary oxygen for the cells and carrying out the carbon dioxide formed as a result of metabolic events. During this process, which we call breathing, the lungs encounter many ... -
Akne Tedavisi için İlaç Yüklü Mikroiğneli Yamaların Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2023)Acne vulgaris is a common and chronic disease, especially during adolescence, due to various factors such as inflammation of the pilosebaceous units of the skin, colonization of the Propionibacterium acnes bacterium, ... -
Anjiyogenik Mikroiğnelerin Geliştirilmesi ve Karakterizasyonu
(Fen Bilimleri Enstitüsü, 2024)Angiogenesis plays a crucial role in tissue repair processes, ensuring the continuation of important cellular processes as stem cell differentiation, cell proliferation, and migration during tissue repair. It also plays a ... -
Anti-Her2 SCFV Antikor Fragmanının Escherichia coli Bakterisinde Üretim Bölgesinin Optimizasyonu
(Fen Bilimleri Enstitüsü, 2022)Antibodies and antibody fragments are used in the diagnosis, imaging, and target-specific treatments of various diseases such as cancer and viral infections. It also has an important place in combating infectious diseases. ... -
Antibakteriyel Aljinat Mikrobaloncuk Yapıların Mikroakışkan Sistemle Hazırlanması
(Fen Bilimleri Enstitüsü, 2021)Microbubbles produced with microfluidic systems have been used as contrast agents in ultrasound radiography for approximately 30 years. In recent years, it has been successfully used in different biomedical applications ... -
Aptamer Temelli Afinite Kromatografisiyle Protein C Saflaştırılmasının Araştırılması
(Fen Bilimleri Enstitüsü, 2021-12-30)Protein C (PC) is a vitamin K-dependent plasma protein. Activated Protein C (APC) is a glycoprotein derived from protein C. It is formed by cleavage of an activation peptide by the thrombin-linked thrombomodulin (T-TM) ... -
Biyobozunur Plastik Polihidroksialkanoatların Bacillus Megaterium’da Genetik Mühendisliği Yoluyla Üretiminin Artırılması
(Fen Bilimleri Enstitüsü, 2021)Fossil fuel-derived plastic materials, have currently production and consumption values at increasing quantities, due to their lightness, easy malleability and economical reasons. Owing to their poor degradation rates and ... -
Bor, Çinko, Magnezyum ve Kalsiyum İçeren Biyoaktif Seramik Tozların Akrilik Kemik Çimentosunun Isıl ve Mekanik Özelliklerine Etkilerinin İncelenmesi
(Fen Bilimleri Enstitüsü, 2024)Acrylic bone cements are a two-component system consisting of powder and liquid phase. It is frequently used in orthopedic surgery to provide prosthesis fixation. The paste-like mixture formed after mixing the powder ... -
Böbrek Transplantasyonu Yapılacak PRA (Panel Reaktif Antikor) Pozitif Hastalarda Hla Haplotipleri İle İmmünofenotip İlişkisinin Araştırılması
(Fen Bilimleri Enstitüsü, 2022)The Human Leukocyte Antigen (HLA- Human Leucocyte Antigen) has an extremely complex morphology. This complex structure is an important factor that causes incompatibility between the patient and the donor, especially when ... -
Centella Asıatıca Bitki Özütü ile Kaplı Gümüş Nanopartikül İçeren Polimer Liflerin Yara İyileştirici Etkisinin in Vitro ve in Vivo Araştırılması
(Fen Bilimleri Enstitüsü, 2021)In this study, we synthesized functional silver nanoparticles (AgNPs) from silver ions using the therapeutic plant extract of Centella asiatica (CA). The formation of AgNPs coated with CA functional groups (CA-AgNPs) is ... -
Deselülerize Miyokard-Elastomer Yamaların Hazırlanması ve In Vitro Performanslarının İncelenmesi
(Fen Bilimleri Enstitüsü, 2021)Heart failure is the final stage of most cardiovascular diseases, such as myocardial infarction. Unlike other tissues such as bone and skin, heart tissue does not have the ability to regenerate and repair itself. This ... -
Development of Jak1 Sirna Medıated Nanotherapeutıcs for Non-Melanoma Skın Cancer Therapy
(Fen Bilimleri Enstitüsü, 2021-06)Non-melanoma skin cancer is one of the most common cancers with still no effective treatment. Due to the side effects observed after long and high dose treatments and acquired resistance to the chemotherapy drugs, different ... -
Doku İskelesi-Destekli Perfüzyon Biyoreaktör İşletim Parametrelerinin Preosteoblastların Üreme ve Osteojenik Farklılaşma Potansiyelleri Üzerine Etkilerinin Araştırılması
(Fen Bilimleri Enstitüsü, 2015-09-18)ABSTRACT INVESTIGATION OF EFFECTS OF SCAFFOLDSUPPORTED PERFUSION BIOREACTORS PROCESS PARAMETERS ON THE PROLIFERATION AND OSTEOBLASTIC DIFFERENTIATION OF PREOSTEOBLASTS Gizem AYDIN Master of Science, Department of ... -
Dolgulu Yatak Biyoreaktörde Mezenkimal Kök Hücre Üretiminin Araştırılması
(Fen Bilimleri Enstitüsü, 2020-08-20)In the thesis study, it was aimed to investigate mesenchymal stem cell production in packed bed bioreactor where non-woven polyester fiber matrices (NWPF) are used as carrier. In the preliminary studies, MC3T3-E1 mouse ... -
Epilepsi Tedavisinde Kullanılmak Üzere Fenitoin Yüklü Katı Lipid Nanopartiküllerin Sentezi ve Karakterizasyonu
(Fen Bilimleri Enstitüsü, 2022)Epilepsy is a chronic neurological disease that affects 1% of the world's population and is characterized by spontaneous recurrent seizures. Common causes include pathogenic genetic variants in critical neuronal genes, ... -
Fonksiyonel Pet Nano Fiberlerin Üretilmesi ve Yara Örtüsü Olarak Kullanmak Üzere Modifiye Edilmiş Pet Fiberlere Protein Kaplı Gümüş Nanoparçacıkların Adsorpsiyonu
(Fen Bilimleri Enstitüsü, 2020)In this study, silver nanoparticles (S-AgNPs) coated with sericin were adsorbed on poly (ethylene terephthalate)-g-poly(hydroxyethylmethacrylate) (PET-g-HEMA) nanofibres and the use of the obtained material as wound dressing ... -
Fotostimülasyonun 2 ve 3 Boyutlu in vitro Hiperglisemik Modellerde İnsan Dermal Fibroblast, Keratinosit ve Endotel Hücreleri Üzerindeki Etkinliğinin İncelenmesi
(Fen Bilimleri Enstitüsü, 2024)This study is supported by the Scientific Research Projects Coordination Unit (BAP) of Hacettepe University as part of the comprehensive research project titled "Investigation of the Effectiveness of Photostimulation in ... -
Geliştirilen Üç Boyutlu Böbrek Proksimal Tübül Modelinde Nefrotoksisite Değerlendirmesi
(Fen Bilimleri Enstitüsü, 2023)Acute kidney injury (AKI) is an important health problem causes the death of 2 million people worldwide every year with high morbidity and mortality. One of the important causes of AKI is drug-induced nephrotoxicity. After ... -
Göz İçi Tümör Radyocerrahisi İçin Göz Takip Sistemi ve Kalite Güvence Fantomunun Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2023)Uveal malignant melanoma is the most common type of intraocular cancer in adults. Stereotactic radiosurgery applications are often used in the treatment of such tumors. In these radiation treatments performed with external ...
