Bölüm "Kök Hücre Bilimleri" Kök Hücre Bilimleri için listeleme
Toplam kayıt 25, listelenen: 1-20
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Akut myeloblastik lösemi (aml) hastalığı hücrelerinin aptamer temelli akım sitometrik profillenmesi
(Sağlık Bilimleri Enstitüsü, 2023-02)AKCA O, Aptamer Based Flow Cytometric Profiling in Acute Myeloblastic Leukemia (AML) Disease Cells. Hacettepe University Graduate School of Health Sciences Stem Cell Program Master Thesis, Ankara, 2023. Aptamers are short, ... -
Allojenik Mezenkimal Kök Hücreler ve Mikroakışkan Sistemle Vücut Dışında Testisteki Spermatogonyal Kök Hücre Mikroçevresinin Devamlılığının Sağlanması
(Sağlık Bilimleri Enstitüsü, 2023)Chemoradiotherapeutics used in childhood cancers result in permenant infertility in half of male patients. Bone marrow derived mesenchymal stem cells (BMMSC) share some of their secretomes and their embryonic origin with ... -
Aoc3’ün İnflamatuar ve Neoplastik Kolon Hastalıklarındaki Rolünün Araştırılması
(Sağlık Bilimleri Enstitüsü, 2024)The AOC3 gene is located on chromosome 17 and encodes the protein AOC3 (VAP-1), which is involved in leukocyte trafficking during inflammation. AOC3 is expressed by many different cell groups such as endothelium, adipocytes, ... -
Apc Mutant Fare İntestinal Organoidlerinde Wnt Yolak Modülasyonunun Kök Hücreler Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022)One of the most important causes of colorectal cancer development is mutations of genes involved in the WNT signaling pathway. In the vast majority of cases, APC tumor suppressor gene mutations, which act as negative ... -
Apc Mutant Fare Modelinde Azaltılmış Bdnf Ekspresyonunun İntestinal Tümör Gelişimi Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2023-04)Gök, A., Effects of Reduced Bdnf Expression on Intestinal Tumor Development in Apc Mutant Mouse Model, Hacettepe University Graduate School of Health Sciences Department of Stem Cell Sciences Doctor of Philosophy Thesis, ... -
Baş Boyun Kanserli Hastaların Tükürük Örneklerinden İzole Edilen Eksozom ve Bakterilerin, Sağlıklı Kemik İliği Mezenkimal Kök Hücreler Üzerine Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-01-25)Recently, in the development of head and neck cancers, the components, which are responsible for the interaction between cells and surrounding healthy tissues, in the tumor microenvironment have become a burgeoning area. ... -
GENE EXPRESSION OMNIBUS (GEO) veribankası kaynakları kullanılarak nöral krest kaynaklı dental kök hücrelerinin, nörojenik rejenerasyon ile ilişkili gen ifade profillerinin karşılaştırılmalı olarak incelenmesi.
(Sağlık Bilimleri Enstitüsü, 2022-07-12)AKMAN AC. Comparative analysis of neurogenic regeneration-associated gene expression profiles of neural crest-derived dental stem cells using GENE EXPRESSION OMNIBUS (GEO) database resources. Hacettepe University Graduate ... -
Hematopoetik Kök Hücre Gen Tedavi Kültür Koşulları ve Engraftman Optimizasyonu
(Sağlık Bilimleri Enstitüsü, 2021)RAG2 severe combined immunodeficiency (SCID) is a rare, inherited primary immunodeficiency (PID), characterized by a T-/B-/NK+ phenotype and is treated with hematopoietic stem cell (HSC) transplantation. When no suitable ... -
İnfantil Osteopetrozisli Hasta Uyarılmış Pluripotent Kök Hücreleri ile Osteoklast Defektinin Modellenmesi,Osteoklast ve Hematopoietik Niş İlişkisi
(Sağlık Bilimleri Enstitüsü, 2019)Malignant infantile osteopetrosis is an autosomal recessive disorder. The only available treatment is allogeneic hematopoietic stem cell transplantation. The objective of this study was to model hematopoietic niche in ... -
İnsan somatik hücrelerinin uyarılmış plüripotent kök hücrelere yeniden programlanması sürecinde arilhidrokarbon reseptörü sinyalizasyonundaki değişimlerin incelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)Sevindi S., Investigation of Changes in Arylhydrocarbon Receptor Signaling in the Reprogramming of Human Somatic Cells into Induced Pluripotent Stem Cells, Hacettepe University Graduate School of Health Sciences Department ... -
İnsan Uyarılmış Pluripotent Kök Hücrelerinden Spermatogonyal Kök Hücre ve Öncülü Primordiyal Germ Hücrelerinin Farklılaştırılması ve Çoğaltılmasında Endokannabinoidlerin Etkisi
(Sağlık Bilimleri Enstitüsü, 2024)Male factor is responsible for 50% of infertility cases, while 15% are due to germ cell aplasia resulting in no sperm. Assisted reproductive techniques (ART) protocols are inadequate for men with germ cell aplasia to have ... -
Kemik İliği Yağ Tabakasından Elde Edilen Mezenkimal Kök Hücrelerin Karakterizasyonu ve Subkutan Yağ ve Kemik İliği Kökenli Mezenkimal Kök Hücreleri ile Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2020-09)Bone marrow adipose tissue (BMAT) has different properties than other adipose tissues. Recent studies have shown the effects of bone marrow adipose tissue on development / progression of acute myeloblastic leukemia (AML), ... -
Methionine Metabolism in Human Fetal, Adult and Cancer Stem Cells
(Sağlık Bilimleri Enstitüsü, 2021-08-09)Methionine is an essential amino acid critical in protein synthesis and methylation reactions. In this thesis, it is aimed to determine the effect of methionine on different human stem cell groups. Mesenchymal stem cells ... -
Mezenkimal Kök Hücre Üretiminde İn Vitro Temelli Metabolomik ve Analizler
(Sağlık Bilimleri Enstitüsü, 2020-02-12)Karaağaç Akyol, T. Metabolomic And Analyzes In In-Vitro Based On The Production Of Mesenchimal Stem Cells, Hacettepe University Graduate School of Health Sciences Stem Cells Program Doctor of Philosophy Thesis, Ankara, ... -
Mezenkimal Kök Hücre Yaşlanmasında Nf-Κb/P65 ve Pknox2 Protein-Protein Etkileşimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2021)Mesenchymal stem cells undergo replicative senescence by cultivating in vitro and as the passage extends they lose their stem cell properties. Previous study of our group investigating proteomics of the co-immunoprecipitated ... -
Mikrorna-21 Baskılanmış Meme Kanseri Kök Hücrelerinin İnsan Kemik İliğinden İzole Edilen Telositler ve Telosit Kaynaklı Mitokondriler ile Ko-Kültürü
(Sağlık Bilimleri Enstitüsü, 2023)The aim of this thesis study was to investigate the contribution of telocytes and telocyte-derived mitochondria, which have also been identified in breast tumours, to the tumour development of breast cancer stem cells via ... -
Myeloid Kanserlerde Kemik İliği Mikroçevresinin Metabolik Profilinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2024-07-01)ŞAHİN A. B., Investigation of the metabolic profile of the bone marrow microenvironment in myeloid cancers, Hacettepe University Graduate School of Health Sciences, Stem Cell Program Master Thesis, Ankara, 2024. Metabolic ... -
Nörofibromatozis Tip 1(Nf1) Kaynaklı Mezenkimal Stromal Hücrelerin Detaylı Karakterizasyonu
(Sağlık Bilimleri Enstitüsü, 2022-10-07)Neurofibromatosis type 1 (NF1) is an inherited autosomal dominant disease characterized by mutation in the neurofibromin (NF1) tumor suppressor gene. The lack of neurofibromin, the gene product, causes defects in the nervous ... -
Oksidatif Stres Altında Mezenkimal Kök Hücrelerde Src-YAP Aktivitesi ve Apoptoz ile İlişkisi
(Sağlık Bilimleri Enstitüsü, 2024)One of the reasons for the post-transplantation loss of mesenchymal stem cells (MSCs), which are used in the treatment of many diseases with their immunomodulatory and regenerative properties, is oxidative stress-induced ... -
Optimization and Risk Assessment of RAB27A-/- Gene Therapy Alternatives Using Current Molecular Techniques and Technologies
(Sağlık Bilimleri Enstitüsü, 2024-02-09)EROL DUYAR, Ö.D. Optimization and Risk Assessment of RAB27A-/- Gene Therapy Alternatives using Current Molecular Techniques and Technologies. Hacettepe University Graduate School of Health Sciences Stem Cell Doctor of ...
