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Anadolu'daki Nadir Otoinflamatuvar Hastalıklar ile İlişkili Mutasyonlar için Alel Yaşının Hesaplanması
(Sağlık Bilimleri Enstitüsü, 2024)Autoinflammatory diseases are diseases that emerge from the abnormalities in the innate immune system of the individuals. In the crisis times, one of the mostly seen symptom is the high amount of inflammation biomarkers. ... -
Postpartum Dönemde Vücut Algısının Cinsel Yaşam Kalitesine Etkisi
(Sağlık Bilimleri Enstitüsü, 2024)This research was conducted as adescriptive and cross-sectional study to examine the effect of women’s postpartum body image on their quality of sexual life. The research as conducted at Kastamonu Training and Research ... -
Acil Tıp Asistanlarında Kadavra ve Manken Temelli Cerrahi Havayolu Simülasyon Eğitiminin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)In this study, we aimed to evaluate the mannequin and cadaver-based surgical airway simulation training program for emergency medicine assistants in the ADDIE model and compare cadaver and mannequin-based surgical ... -
Optimization and Risk Assessment of RAB27A-/- Gene Therapy Alternatives Using Current Molecular Techniques and Technologies
(Sağlık Bilimleri Enstitüsü, 2024-02-09)EROL DUYAR, Ö.D. Optimization and Risk Assessment of RAB27A-/- Gene Therapy Alternatives using Current Molecular Techniques and Technologies. Hacettepe University Graduate School of Health Sciences Stem Cell Doctor of ... -
Polikistik Over Sendromlu Ergenlerde Kas Kuvvetinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2024)Polycystic ovary syndrome (PCOS) is an endocrinological disease, the foundations of which are are laid in adolescence, is most common in women of reproductive age and progresses with androgen elevation and chronic anovulation. ... -
Image, Sequence, and Interactome Based Prediction of Subcellular Localization of Proteins
(Sağlık Bilimleri Enstitüsü, 2024-01-31)Knowledge of subcellular localization (SL) of proteins is essential for drug development, systems biology, proteomics, and functional genomics. Due to the high costs associated with experimental studies, it has become ... -
Kadınların Serviks Kanseri Taramasına İlişkin Tutumları ile Kanser Bilgi Yükü ve Kanser Kaygısı Arasındaki İlişkinin Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2024-01-22)Ozkan, Nursen. Determining the Relationship Between Women's Attitudes Towards Cervical Cancer Screening and Cancer Information Load and Cancer Anxiety, Master's Thesis, Department of Obstetrics and Gynecology Nursing of ... -
Oksidatif Stres Altında Mezenkimal Kök Hücrelerde Src-YAP Aktivitesi ve Apoptoz ile İlişkisi
(Sağlık Bilimleri Enstitüsü, 2024)One of the reasons for the post-transplantation loss of mesenchymal stem cells (MSCs), which are used in the treatment of many diseases with their immunomodulatory and regenerative properties, is oxidative stress-induced ... -
Yenidoğanlarda Fototerapi Tedavisi Esnasında Amplitüd Entegre Elektroensefalografi ile Beyin Matürasyonu İzlemi
(Sağlık Bilimleri Enstitüsü, 2023-12-19)Hyperbilirubinemia is a common problem in the neonatal period. The first choice of treatment is phototherapy. Amplitude integrated electroencephalography (aEEG) monitoring has been widely used in neonatal units. We aimed ... -
Kumaş Fazı Emici Ekstraksiyonu ile İlaç Etkin Maddelerinin Farmasötik Preparat ve Biyolojik Materyalden Analizi için Analitik Yöntem Geliştirilmesi ve Validasyonu
(Sağlık Bilimleri Enstitüsü, 2024-01-08)Fabric phase absorbent extraction (FPSE) is a sample preparation technique that has come to the fore in recent years. Microextraction devices prepared by coating a fabric surface with different sorbents enable the analysis ... -
Kord Kanındaki Kemokin Düzeylerinin Prematüre Bebeklerdeki Oksidatif Stres Kaynaklı Morbiditeler ile İlişkisi
(Sağlık Bilimleri Enstitüsü, 2023)Oxidative stress occurs when free radicals increase and exceed the levels of antioxidant mechanisms that can neutralize them. It causes tissue damage by causing protein, lipid and polysaccharide oxidation, DNA fragmentation, ... -
Adölesanlarda Yeme Bozukluğu Sıklığının Saptanması ve Beslenme Alışkanlıklarının Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)ABSTRACT Mirioğlu, S.Asessment of Eating Disorders Prevelance and Nutrition Habits in Adolesant Hacettepe University, Graduate School of Health Sciences, Nutrition and Food Sciences Master Thesis, Ankara, 2023 It was ... -
Mikrorna-21 Baskılanmış Meme Kanseri Kök Hücrelerinin İnsan Kemik İliğinden İzole Edilen Telositler ve Telosit Kaynaklı Mitokondriler ile Ko-Kültürü
(Sağlık Bilimleri Enstitüsü, 2023)The aim of this thesis study was to investigate the contribution of telocytes and telocyte-derived mitochondria, which have also been identified in breast tumours, to the tumour development of breast cancer stem cells via ... -
Migren Tedavisinde Kullanılmak Üzere Geliştirilen Hibrit Nanopartiküllerin İn Vitro ve İn Vivo Etkinliklerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)Kaya MZ. Evaluation of In Vitro and In Vivo Activities of Hybrid Nanoparticles Developed for the Treatment of Migraine, PhD Thesis, Pharmaceutical Technology Program, Graduate School of Health Sciences, Hacettepe University, ... -
Automated Design vf Drug Candidate Molecules with Deep Graph Learning
(Sağlık Bilimleri Enstitüsü, 2023)The discovery of new drug candidate molecules is an important step in the process of drug development. Deep generative learning, a frequently used approach in the field of artificial intelligence in recent years, has emerged ... -
Apc Mutant Fare Modelinde Azaltılmış Bdnf Ekspresyonunun İntestinal Tümör Gelişimi Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2023-04)Gök, A., Effects of Reduced Bdnf Expression on Intestinal Tumor Development in Apc Mutant Mouse Model, Hacettepe University Graduate School of Health Sciences Department of Stem Cell Sciences Doctor of Philosophy Thesis, ... -
Heterojen Biyomedikal Verinin Bilgi Çizgeleri ve Derin Öğrenme Tabanlı Analizi ile Protein Fonksiyonlarının Otomatik Tahmini
(Sağlık Bilimleri Enstitüsü, 2023-07-31)Proteins are vital for cellular processes, and accurately determining their functions is crucial for understanding complex biological mechanisms. Computational approaches have emerged as alternatives to expensive and ... -
Myastenia Gravis’li Bireylerde Kognitif İşlevin Basit ve Kompleks Reaksiyon Zamanı Yöntemi ile Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)Myasthenia Gravis (MG) is an autoimmune disease caused by antibodies against mainly postsynaptic proteins that play an important role in the function of the neuromuscular junction. Function disruption of the junction leads ... -
Hemşirelik Öğrencilerinin Ventilatörle İlişkili Pnömoninin Önlenmesine Yönelik Beceri Geliştirme Süreçlerine Simülasyonun Etkisi
(Sağlık Bilimleri Enstitüsü, 2023-07-11)This research was conducted in a single group pretest-posttest quasi-experimental design to determine the impact of scenario-based simulation training on the development of skills in nursing students for the prevention ... -
Prematüre bebeklerde prenatal Doppler Ultrasonografi bulguları ile postnatal serebral Near-Infrared Spektroskopi (NIRS) ölçümlerinin uyumluluğunun araştırılması
(Sağlık Bilimleri Enstitüsü, 2023-06-19)Perinatal and neonatal surveillance of intrauterine growth restriction (IUGR) has gained importance due to its negative impacts on cerebral oxygenation. In this thesis study, it was aimed to compare fetal cerebral and ...