Dil "en" Sağlık Bilimleri Enstitüsü Tez Koleksiyonu için listeleme
Toplam kayıt 12, listelenen: 1-12
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Assessment of The Role and Antıoxıdatıve And Antıapoptotıc Effects of Delta-Opıoıd Peptıde D-Ala2-Leu5-Enkephalın on The Vıabılıty of Hematopoıetıc Stem Cells
(Sağlık Bilimleri Enstitüsü, 2019)Mammadova A., Assessment of the Role and Antioxidative and Antiapoptotic Effects of Delta-opioid Peptide D-Ala2-Leu5-Enkephalin on the viability of Hematopoietic Stem Cells, Hacettepe University Graduate School of Health ... -
Automated Design vf Drug Candidate Molecules with Deep Graph Learning
(Sağlık Bilimleri Enstitüsü, 2023)The discovery of new drug candidate molecules is an important step in the process of drug development. Deep generative learning, a frequently used approach in the field of artificial intelligence in recent years, has emerged ... -
Bayesian Networks for Omics Data Analysis in Hepatocellular Carcinoma Single-Cell Sequencing
(Sağlık Bilimleri Enstitüsü, 2021)Single cell multi omics techniques have shown an advancement in unrevealing complex diseases like cancer heterogeneity by providing multi-faceted insight into their individual cellular regulations. In this study, a machine ... -
Characterization of Acute Myeloid Leukemia Stem Cells By Niche-Like Coculture System
(Sağlık Bilimleri Enstitüsü, 2019)AML heterogeneity show evidence of hierarchical cellular organization and at the top of this hierarchical structure there is a rare group of LSCs. It was mentioned that there is an association between LSCs and disease ... -
Hox and Tale Transcrıptıon Factors in Fanconı Anemıa Bone-Marrow Mesenchymal Stem Cells: Gene Expressıon and Proteın Interactıons
(Sağlık Bilimleri Enstitüsü, 2018)HOX/TALE proteins maintain tissue identity and their altered expression is seen in many cancers. The main aim of this thesis is to evaluate whether HOX/TALE gene expression changes due to genomic instability. To answer ... -
Image, Sequence, and Interactome Based Prediction of Subcellular Localization of Proteins
(Sağlık Bilimleri Enstitüsü, 2024-01-31)Knowledge of subcellular localization (SL) of proteins is essential for drug development, systems biology, proteomics, and functional genomics. Due to the high costs associated with experimental studies, it has become ... -
Kemik İliği Mezenkimal Kök Hücrelerinde p53 Yolağı Regülasyonunda PKNOX2 ve Etkileşimlerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2023)Mesenchymal Stem Cells (MSC) are good platforms to study in-vitro molecular mechanisms. Like all cells, MSCs detect and respond to various stimuli with molecular signal mechanisms. p53 signal pathway is a well-known molecular ... -
Methionine Metabolism in Human Fetal, Adult and Cancer Stem Cells
(Sağlık Bilimleri Enstitüsü, 2021-08-09)Methionine is an essential amino acid critical in protein synthesis and methylation reactions. In this thesis, it is aimed to determine the effect of methionine on different human stem cell groups. Mesenchymal stem cells ... -
Optimization and Risk Assessment of RAB27A-/- Gene Therapy Alternatives Using Current Molecular Techniques and Technologies
(Sağlık Bilimleri Enstitüsü, 2024-02-09)EROL DUYAR, Ö.D. Optimization and Risk Assessment of RAB27A-/- Gene Therapy Alternatives using Current Molecular Techniques and Technologies. Hacettepe University Graduate School of Health Sciences Stem Cell Doctor of ... -
Synthesıs and Bıologıcal Actıvıty Studıes of Some 3-Aryl- 2-(4-(Substıtutedphenyl)Thıazol-2-Yl)Acrylonıtrıle Derıvatıves
(Sağlık Bilimleri Enstitüsü, 2023-04-27)Anas, S., Synthesis and Biological Activity Studies of Some 3-Aryl-2-(4- (substitutedphenyl)thiazol-2-yl)acrylonitrile Derivatives, Hacettepe University Graduate School of Health Sciences, Faculty of Pharmacy Department ... -
The Effect of Melatonın on Hıppo Sıgnallıng Pathway in Dental Pulp Stem Cells
(Sağlık Bilimleri Enstitüsü, 2020)Dental pulp stem cells (DPSCs) are heterogeneous multipotent adult stem cells with high capacity to differentiate to both neuronal and non-neuronal cell lineage. Hippo pathway regulates diverse cellular processes, including ... -
The Perceptions of Healthcare Professionals Serving Migrant, Refugee and Asylum Seekers in the Primary Healthcare Centers of Hatay, Şanlıurfa, Gaziantep and İzmir About Healthcare Provision, and Their Level of Burnout
(Halk Sağlığı Enstitüsü, 2021)Objective: The purpose of this study is to investigate the level of burnout and perceptions of health professionals serving in primary healthcare centers in four provinces in Turkey, namely Gaziantep, Hatay, İzmir, ...
