Bisfenol A'nın Diyabet ve Obezite ile İlişkisinin Değerlendirilmesi

Abstract

Bisphenol A (BPA), is an endocrine distrupting chemical known to effect the glucose metabolism and adipose tissue in vitro. Limited number of clinical studies investigating the relationship between BPA and obesity and diabetes failed to identify a relationship. In this study we aimed to analyze and compare BPA levels in patients with diabetes, prediabetes and participants having normal glucose tolerance as well as in obese and nonobese individuals. The study was conducted in Hacettepe University Endocrinology Unit between May 2012-September 2012 and included age-, sex- and body mass index- (BMI) matched 50 patients with type 2 diabetes (DM), 45 patients with prediabetes and 45 participants with normal glucose tolerance. All the participants in the groups were categorized into two groups according to BMİ≤30 kg/m2. Anthropometric measurements, body composition analyses parameters performed by bioimpedance analyses were recorded for all participants. Lipid parameters, BPA, adiponectin, fasting plasma glucose, hemoglobin A1c (HbA1c) were measured. BPA levels in diabetes group were higher than BPA levels in prediabetes and control group (p<0.001); whereas adiponectin levels were lower in diabetes group than adiponectin levels in prediabetes and control group (p=0.038). Body composition parameters were similar across the groups, triglyceride and waist to hip ratio (WHR) were higher in diabetes (p=0.012 and p=0.044, respectively). In the corelation analyses, BPA was negatively correlated with adiponectin and HDL cholesterol (p=0.041, r=-0.173; p=0.001, r=-0.282, respectively), and positively correlated with HbA1c and WHR (p<0.001, r=0.330; p=0.003, r=0.254, respectively). BPA levels according to BMI in the groups were similar to each other. In the present study we found that BPA levels were significantly higher in diabetes. Similar BPA levels in prediabetes and normal glucose tolerance did not indicate a cause and effect relation. Negative correlation of BPA with adiponectin and HDL cholesterol, lower levels of adiponectin in diabetes vii suggested a causative role of insuline resistance. BPA and obesity were not related to each other in the present study.