Kanser Enstitüsü Tez Koleksiyonu: Recent submissions
Now showing items 41-60 of 70
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Effect of Calcıum Carbonate Encapsulatıon on the Oral Actıvıty of Cpg Olıgodeoxynucleotıdes and Assessment of the Response of Human Monocytes to Tlr Lıgands
(Sağlık Bilimleri Enstitüsü, 2018-03)Toll-like receptor (TLR) ligands modulate immune responses and have been used in immunotherapy. Clinical trials designed to evaluate the utility of CpG ODN, a synthetic TLR9 ligand, relied on parenteral routes of administration. ... -
Investigation of Lung Cancer Cell Culture Supernatants Activated with Tlr Agonists Effect on Macrophage Polarization
(Kanser Enstitüsü, 2018)It is well known that inflammation is involved in the development of lung cancer. Macrophages in the tumor microenvironment are the anti-inflammatory M2 type and anti-tumor type M1. Inflammatory cytokines, such as IL-1β, ... -
Vajinal Kaf Brakiterapi Uygulamaları için Yoğunluk Ayarlı Aplikatör Tasarımı: Dozimetrik Fizibilite Çalışması
(Kanser Enstitüsü, 2018)Depending on technological advances in radiotherapy, the use of three-dimensional (3D) treatment planning in brachytherapy (BRT) applications has provided a great advantage in terms of efficacy of treatment in gynecological ... -
Mikozis Fungoides Mikroçevresinde Bulunan Dermal Fibroblastların Anti-Tümör İmmün Yanıta Etkisi
(Sağlık Bilimleri Enstitüsü, 2017-12)Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. The interaction of the neoplastic lymphocytes with their microenvironment is of crucial importance in disease progression. Cancer associated ... -
3 Boyutlu Baskı Teknolojisi Kullanılarak Hastaya Özgün Konturlarla Oluşturulan Fantom Tasarımı ve Üretimi ile Mikro-Çok Yapraklı Kolimatör Tabanlı Beyin ve Başboyun Yoğunluk Ayarlı Radyoterapi Planlarının Kalite Kontrolü
(Sağlık Bilimleri Enstitüsü, 2017)SUNEL, S. Quality control of micro-multileaf collimator based brain and head-and-neck intensity modulated radiotherapy plans with patient-specific phantom design and production using 3D printing technology. Hacettepe ... -
3′End Maturation of Human Telomerase Rna Component (Terc) and Its Effects on Telomere Dynamics
(Sağlık Bilimleri Enstitüsü, 2017-09-15)Telomerase RNA Component (TERC) is the non-coding RNA template and scaffold of the telomerase holoenzyme. TERC level has been shown to be a limiting factor for telomerase activity, lower levels resulting in telomere diseases ... -
Modulation of Glucocorticoid Induced Tumor Necrosis Factor Receptor (GITR)-GITR Ligand (GITRL) Interaction in Breast Cancer Cells Under the Control of Ataxia Telangiectasia Mutated (ATM) Promoter
(Kanser Enstitüsü, 2017-07-21)Treatment response for basal-like breast cancers (BLBC) is limited and this aggressive breast cancer sub-type has poor prognosis and high mortality. Our first aim is to investigate ATM activity in BLBC cell lines with ... -
The Effect of Acute Myeloid Leukemia Cells Expressing PD-L2 Co-Stimulatory Molecule on Helper T Cell Activation
(Sağlık Bilimleri Enstitüsü, 2017-07-25)The binding of PD-1 to its ligands (PD-L1 and PD-L2) inhibits and/or regulates T cell responses. Myeloid leukemia cells can express both co-activatory and co-inhibitory molecules simultaneously. The function of PD-L1 in ... -
Kronik Periodontiti Olan Hastalarda Kanser İnsidansının Değerlendirilmesi
(Kanser Enstitüsü, 2017)Previous studies have noted possible associations between periodontitis and the risk of various cancers, particularly head and neck cancers, esophageal cancer, lung cancer, pancreatic cancer, breast cancer and non-Hodgkin ... -
Gastrointestinal Sistem Kanserli Hastalarda Mide Doluluğunun Radyoterapiye Etkisi
(Kanser Enstitüsü, 2017)In the treatment of gastrointestinal system (GIS) cancers, radiotherapy (RT) is frequently applied as three dimensional conformal RT (3BKRT) or intensity adjusted RT (YART). GIS tumors are very sensitive to environmental ... -
Cyberknife® X-Sight® Vertebra Takip Sisteminin Vertebra Dışı Lezyonlarda Uygulanabilirliğinin Araştırılması
(Kanser Enstitüsü, 2017-03-25)One of devices which uses the ablative dose for the Stereotactik body radiation theraphy (SBRT) is CyberKnife® Stereotactic Radiosurgery System. This device, has different tracking system from other devices. This systems ... -
Vulva Kanserinde Elektron-YART Hibrit Tedavi Modalitesinin Tedavi Planlama Sistemi ve Dozimetrik Yöntemlerle İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2017-02-20)In recent years, in the treatment of vulvar cancer, intensity modulated radiation therapy (IMRT) have been used instead of 3 dimensional conformal radiotherapy (3DCRT). In this thesis study, 7 patients who were diagnosed ... -
Cyberknife Synchrony® Solunum Takip Sisteminin Polimer Jel Dozimetre ile Üç Boyutlu Performans Analizi
(Kanser Enstitüsü, 2017-02-20)ŞAHİN, M. C. Three Dimensional Performance Analysis Of Cyberknife Synchrony® Respiratory Tracking System Using Polymer Gel Dosimeter. Hacettepe University Institute of Health Sciences, Thesis in Radiotherapy Physics ... -
Akciğer Kanserlerinde Stereotaktik Ablatif Beden Radyoterapisinin Toksisite ve Doz - Yanıt İlişkisinin Matematiksel Model ile Görüntü ve Dozimetrik Analizi
(Kanser Enstitüsü, 2017-02-17)In conventional radiotherapy applications, clinicians and physicist rely upon mathematical dose - response models for applied doses to tumor and periphery healthy tissues. However in stereotactic ablative body radiotherapy ... -
Helikal Tomoterapi ile Prostat Işınlamalarında Kritik Organ Dozlarının Cihaz İçi Parametrelere göre Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2017)The treatment planning of Tomotherapy depends on three device parameters, i.e. field width (FW), pitch (P) and modulation factor (MF). Various treatment plans can be generated with different combinations of these parameters. ... -
All-Trans Retinoik Asit (Atra) ve 1Α,25-Dihidroksivitamin D3 (Vitamin D3) ile Uyarılan Akut Miyeloid Lösemi Hücrelerinin T Hücre Yanıtları Üzerine Etkisi
(Kanser Enstitüsü, 2014)ATRA and D3 are the active metabolites of vitamin A and D, respectively. In this study, HL-60 myeloid leukemia cells were progressed through different maturation stages with ATRA, D3, LPS, and IFN-γ. For the determination ... -
Expression and Functional Analysis of Ccrl2 Atypical Chemokine Receptor Variants on Breast Cancer Cells
(Kanser Enstitüsü, 2014)The complex network of chemokines and chemokine receptors is regulated by atypical (decoy) chemokine receptors. Atypical chemokine receptors play role in the termination of inflammatory responses and CCRL2 is the newest ... -
Expression of Toll Like Receptors in Lung Cancer and Investigating Their Effect on Apoptosis
(Kanser Enstitüsü, 2014)Members of the Toll like receptors (TLRs) family play key roles in both innate and adoptive immune responses. TLRs proteins enable host to recognize a large number of pathogen associated molecular patterns such as bacterial ... -
Meme Kanseri Hücrelerinde Kostimülatör B7 Ailesi Ligandlarının Ekspresyonu ve Yardımcı T Hücre Yanıtları Üzerine Etkisi
(Kanser Enstitüsü, 2013)B7 ligands are the most critical costimulatory molecules that regulate T cell responses. Although these molecules are mainly expressed on professional antigen presenting cells, they may also be expressed on tumor cells. ... -
Kolon Kanserli Hastalarda Interlökin 21 ve Interlökin32 Gen Ekspesyon Düzeyleri ve Metastaz Ilişkisi
(Kanser Enstitüsü, 2014)Tumor microenvironment contains tumor cells, immune cells, stroma and stroma associated immune cells. This microenvironment of the immune system cells release chemokines and cytokines which play an important role in the ...
