Özet
ŞAHİN, M. C. Three Dimensional Performance Analysis Of Cyberknife Synchrony®
Respiratory Tracking System Using Polymer Gel Dosimeter. Hacettepe University
Institute of Health Sciences, Thesis in Radiotherapy Physics Program, Ankara,
2017. Tumor movement is a challenging issue for the precise delivery of radiation
for thoracic tumors. The Synchrony respiratory motion tracking system (RMTS) of
Cyberknife® robotic radiosurgery unit synchronizes radiation beam delivery with the
respiration induced tumor motion. This study aims to investigate the performance
of Synchrony RMTS for different movement widths using polymer gel dosimetry. To
the best of our knowledge this is the first study to make the three dimensional
performance analysis of Synchrony RMTS.
The MultiPlan® treatment planning system (TPS) of Cyberknife® was used to deliver
4 Gy to a tumor of 1X1X1 cm3. BrainLab Gating lung phantom was used to simulate
lung movements with three different amplitudes (1 cm, 2 cm and 3 cm). Three
fiducials were inserted to the phantom for tracking. Radiochromic film and polymer
gel dosimetry were used and measurements were compared with the dose
distributions acquired from the TPS. The dose information of irradiated gel were
read out using 1.5 T magnetic resonance imaging. The gamma index values were
analysed using the Ashland FilmQA Pro 3.0 software for film dosimeters and
Polygevero software for gel dosimeters using the 3mm/3% criteria. PolyGevero
gamma index value of ≤1 is accepted as a passing criteria according to the
literature.
The mean 3 mm 3% gamma index values of film dosimetry were 92.6±1.94%,
91.0±4.00%, 90.3±2.04% for tumor motions of 1 cm, 2 cm and 3 cm, respectively
(p<0.001). For polymer gel dosimetry, the mean gamma index values calculated
over almost three million points were 0.56±0.10, 0.60±0.24 and 0.65±0.30 for
tumor motions of 1 cm, 2 cm and 3 cm, respectively (p<0.001). Although the
difference was statistically significant for 3 different amplitudes, the performance of
the system was within the acceptance limits.
Three dimensional performance analysis showed that Cyberknife Synchrony® RMTS
is successful in tumor tracking regardless of the amplitude of movement.
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