Hıv ile Enfekte Yaşlı Bireylerin Tedavilerinin Multidisipliner Ekip Tarafından Değerlendirilmesi ve Klinik Eczacının Rolü

Abstract

With the prolongation of life expectancy in people living with Human Immunodeficiency Virus (HIV), ensuring and maintaining a good quality of life has become a priority goal. This study aimed to improve the quality of life of older (aged ≥50 years) people living with HIV (PLWH) through a multidisciplinary approach (involving infectious disease specialists, geriatricians, and clinical pharmacists) and to compare their health outcomes with those of younger PLWH (aged <50 years) and HIV-negative people aged ≥50 years. The study was conducted prospectively between February 2022 and December 2023. Older PLWH were assessed twice, at baseline and at the 6 months later. The quality of life was measured using the Short Form (SF-36). A total of 145 older PLWH (79.3% male) were followed, with 70 younger PLWH (88.6% male) and 70 HIV-negative people (41.4% male). The number of older PLWH with potentially inappropriate medication use significantly decreased in the second interview (p<0.001). The baseline SF-36 scores of older PLWH were similar to those of older HIV-negative people and younger PLWH in terms of physical component summary scores (p=0.101 and p=0.239, respectively). The mental component summary score was also similar between older PLWH and HIV-negative people (p=0.563), whereas it was significantly lower in younger PLWH compared to older PLWH (p=0.001). At the second interview, significant improvements were observed in all subscale scores of the SF-36, including both physical and mental component summary scores for older PLWH (p<0.05). This study demonstrated that multidisciplinary team assessment, including clinical pharmacists, is effective in improving quality of life as well as clinical improvements in older PLWH. Age-specific interventions need to be developed to improve the quality of life in all PLWHs throughout life.