PREMATÜRE RETİNOPATİSİNİN PROGNOZUNDA SİSTEMİK İMMÜN-İNFLAMASYON İNDEKSLERİNİN DEĞERLENDİRİLMESİ
Özet
Purpose: To evaluate Systemic Immuno-Inflammation Indices and ROP
prognosis.
Methods: Retrospective study. This study included 109 patients with premature
birth (≤32 weeks gestational age) and/or low birth weight (≤1500 g) at Hacettepe Hospital
between January 1, 2020 and January 1, 2024. Serum neutrophil-to-lymphocyte ratio
(NLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index
(SII), and systemic inflammation response index (SIRI) were calculated at birth and one
month after birth. The relationship between ROP development, treatment requirement
and systemic immuno-inflammation indices was analyzed.
Results: Infants participating in the study were divided into three groups: without
ROP (n = 32), ROP but not requiring treatment (n = 55), and ROP requiring treatment (n =
21). First month NLR, LMR, SII and SIRI were significantly associated with ROP
development (OR: 3.548, p = 0.01), (OR: 0.706, p = 0.001), (OR: 1.003, p = 0.028), (OR:
1.559, p = 0.03) respectively and NLR, SII and SIRI were found to be risk factors in treatment
required patients (OR: 2.70, p = 0.004), (OR: 1.003, p = 0.01), (OR: 1.366, p = 0.004).
Conclusion: Postnatal first month NLR, SII and SIRI values were found to be
statistically significant risk factors for development and treatment requirement in
retinopathy of prematurity. Further studies are needed for its clinical application.
