KİSTİK FİBROZİSLİ ÇOCUKLARDA TELE REHABİLİTASYON İLE YAPILAN FARKLI EGZERSİZ MODALİTELERİNİN FONKSİYONEL KAPASİTE, OKSİDATİF STRES VE SOLUNUM PARAMETRELERİ ÜZERİNE ETKİSİ

Abstract

Respiratory problems, and decreased functional capacity can be seen in people with cystic fibrosis (CF). Oxidative stress may have an important role in disease pathophysiology. Lung disease or comorbidities in CF may lead to increased oxidative stress. The aim of this randomized controlled study was to investigate the effects of different exercise modalities applied by telerehabilitation on functional capacity, oxidative stres, and respiratory parameters in children with CF. Thirty nine patients with CF were randomly divided into three groups: combined exercise training (13 patients) which consisted of core stabilization exercises and aerobic exercise training, core stabilization exercise group (13 patients) which consisted of only core stabilization exercises, and control group (13 patients) which included physical activity recommendations. Core stabilization exercises were performed 3 days per week in the core stabilization exercise group. The combined exercise training group performed aerobic exercise training 3 days a week in addition to core stabilization exercises the days that core stabilization exercises were not performed. Exercise modalities were performed by a physical therapist via telerehabilitation for 8 weeks, with each session duration 30-45 minutes. Functional capacity (6-minute walking test, modified shuttle walking test), respiratory function (spirometer), respiratory muscle function (mouth pressure device, inspiratory muscle training device), oxidative stress (total antioxidant status, total oxidant status, oxidative stress index, superoxide dismutase, protein carbonyl, malondialdehyde and catalase) and irisin parameters were evaluated. Significant improvements were found in functional capacity in both exercise training groups more in the combined exercise training compared to control group (p<0.05). In addition, significant similar improvements in respiratory muscle function were observed in both exercise training groups compared to the control group (p<0.05). Although total antioxidant status and superoxide dismutase decreased over time (p<0.05), no significant changes were observed for oxidative stress and irisin parameters among the groups after training (p>0.05). Core stabilization exercises applied with telerehabilitation have beneficial effects on functional capacity and respiratory muscle functions in people with CF. Aerobic exercise training combined with core stabilization exercises provides a greater improvement in functional capacity. Further studies are needed to investigate the effects of different exercise trainings on oxidative stress in people with CF.