Pediatrik Kemoterapiye Bağlı Nöropati Ölçeği'nin Türkçe Geçerlilik ve Güvenirlik Çalışması

Abstract

This study aimed to assess the validity and reliability of the “Pediatric Chemotherapy Induced Neuropathy Scale (P-CIN)” developed to evaluate chemotherapy-induced peripheral neuropathy with a patient-centered approach in children who have received or are currently receiving neurotoxic chemotherapy and to adapt it to the Turkish population. The methodologically planned study was completed with the participation of 90 patients between the ages of 8-18 years who had received or were receiving neurotoxic chemotherapy between June 2023 and April 2024 in the inpatient and outpatient clinics of Hacettepe University Oncology Hospital, Department of Pediatric Oncology and Hacettepe University İhsan Doğramacı Children’s Hospital Pediatric Hematology Unit. “Individual Introduction Form”, “Pediatric Chemotherapy-Induced Neuropathy Scale” and “Total Neuropathy Scale Adapted for Children” were used as data collection tools. Language, content, and construct validity methods were used to test the scale's validity. Internal consistency analysis, parallel tests, and test-retest methods evaluated the scale's reliability. For content validity, ratios were calculated for all items, and the values were found to be within the acceptable range. Confirmatory factor analysis was conducted for construct validity. The fit values calculated by confirmatory factor analysis were found to be within acceptable limits. According to the internal consistency analysis results, Cronbach's alpha value of the scale was 0.69. Its correlation with the parallel test was found to be strong (r=0.824) and its temporal invariance was revealed by test-retest (p<0.05). The Pediatric Chemotherapy-Induced Neuropathy Scale, adapted into Turkish, was a valid and reliable measurement tool for evaluating peripheral neuropathy in pediatric patients with cancer aged 8-18 years.