Behçet Hastalarında Diyetle Histamin Alımı ve Klinik Parametreler Arasındaki İlişkinin Değerlendirilmesi

Abstract

Behçet's disease (BD) is a chronic, recurrent inflammatory disease characterized by mucocutaneous lesions such as oral aphthae and genital ulcers, which can affect the ocular, neurological and gastrointestinal systems. It is thought that there is a relationship between the clinical and biochemical findings of Behçet's disease and histamine, which is a mediator with proinflammatory properties found in foods as well as endogenously, and modulates the activity of T and B lymphocytes, neutrophils, eozonophils and basophils. The aim of this study; to determine the amount of histamine intake with food in patients with Behçet's disease and to examine the effect on the biochemical and clinical markers of the disease. 66 participants, 34 women and 32 men, participated in the study. In the questionnaire form, sociodemographic data such as age, gender, smoking and alcohol use, disease status, drug use, nutritional counseling status, anthropometric measurements such as body weight, height, body mass index, physical activity status, mucocutaneous findings, eye and organ involvement, etc. clinical findings, hemoglobin (Hgb), white blood cell (WBC), platelet (Plt), mean erythrocyte volume (MCV), red blood cell distribution width (RDW), neutrophil count, lymphocyte count, NLR (Neutrophil-lymphocyte ratio), PLO (Platelet-lymphocyte ratio), iron binding capacity, ferritin, folate, ESR (erythrocyte sedimentation rate), CRP (C-reactive protein), blood urea nitrogen (BUN), ALT (Alanine aminotransferase), AST (Aspartate aminotransferase) values There is a food consumption frequency form to calculate biochemical findings and dietary histamine intake. Low and high histamine intake groups were divided according to the median value of individuals' dietary histamine intake (mg/day). The incidence of skin lesions, which is one of the clinical findings of the disease, is significantly higher in women (p=0.043), and the incidence of uveitis is significantly higher in men (p=0.008). There was only a significant difference between white blood cell values between the groups with low and high dietary histamine intakes (p=0.037); There was no statistically significant difference between CRP, ESR, hemoglobin, platelet, MCV, RDW, BUN, AST, ALT, iron binding capacity and ferritin values (p>0.05). A statistically significant and positive correlation was found between histamine intake and white blood cell values (r=0.650 ; p=0.05). There was no significant difference between the groups with low and high dietary histamine intake in terms of oral aphthae, genital ulcers, uveitis, skin lesions, gastrointestinal system involvement, joint involvement and vascular involvement (p>0.05). A statistically significant and positive correlation was found between individuals' dietary histamine intake and disease attack frequency (r=0.324 ; p=0.008). In conclusion, considering that some biochemical findings and the frequency of disease attacks in Behçet's disease are affected by dietary histamine intake in this study, considering dietary histamine intake in order to reduce the negative symptoms seen in individuals may be beneficial in the management of the disease.