Kök Hücre Araştırma ve Uygulama Merkezi (PEDISTEM)
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STRES UYARANLARI İLE KOŞULLANDIRILMIŞ İNSAN ASTROSİTLERİNİN FENOTİPİK VE METABOLİK PROFİLİNİN İNCELENMESİ
(Sağlık Bilimleri Enstitüsü, 2024)COŞKUN N.A, Investigation of Phenotypic and Metabolic Profiles of Human Astrocytes Conditioned with Stress Stimuli, Hacettepe University Graduate School of Health Sciences Stem Cell Program Master Thesis, Ankara, 2024 ... -
Hepatosit Büyüme Faktörü (Hgf) ile Lisanslanmış Mezenkimal Kök Hücrelerde Anti-Fibrotik mİRNA İfade Düzeyleri
(Sağlık Bilimleri Enstitüsü, 2024)Alişan, AB., Expression Levels Of Anti-Fibrotic miRNA's in Hepatocyte Growth Factor (HGF) Primed Mesenchymal Stem Cells, Hacettepe University Graduate School of Health Sciences Stem Cell Program Master’s Thesis, Ankara, ... -
Assessment of the Effects Of Melatonın on the Functıonal Defıcıts Induced by Cellular Stress in Obese Donor Derıved Mesenchymal Stem Cells
(Sağlık Bilimleri Enstitüsü, 2024-06-11)Obesity negatively affects different types of stem cells and BM-MSCs from individuals with a high BMI display a severely impaired differentiation capacity, reduced proliferation and increased ER stress. However, the role ... -
Structural Investigation Of Donor Age Effect On Human Bone Marrow Mesenchymal Stem Cells: Ftir Spectroscopy And Imaging
(Springer, 2014)Stem cell studies hold enormous potential for development of new therapies for tissue regeneration and repair. Bone marrow mesenchymal stem cells (BM-MSCs) can differentiate into a variety of nonhematopoietic tissues and ... -
The Potential For Chemical Mixtures From The Environment To Enable The Cancer Hallmark Of Sustained Proliferative Signalling
(Oxford Univ Press, 2015)The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation ... -
Thymbra Spicata Var. Intricata Induces Mesenchymal Stem Cell Proliferation and Osteogenic Differentiation
(Inst Tecnologia Parana, 2017)A natural agent that maintains mesenchymal stem cell (MSCs) viability, promotes osteogenic differentiation while modulating the immunological response could achieve success in regeneration during healing and may also prevent ... -
Lentiviral Hematopoietic Stem Cell Gene Therapy in Inherited Metabolic Disorders
(Mary Ann Liebert, Inc, 2014)After more than 20 years of development, lentiviral hematopoietic stem cell gene therapy has entered the stage of initial clinical implementation for immune deficiencies and storage disorders. This brief review summarizes ... -
Lentiviral Hematopoietic Stem Cell Gene Therapy in Inherited Immune and Lysosomal Enzyme Deficiencies
(CyberLeninka, 2016)Rare diseases affect millions of people worldwide. Many of those are inherited disorders resulting in chronic disability and requiring cost-intensive care. Hematopoietic stem cell gene therapy has been developed over more ... -
Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of Mngie
(Elsevier, 2018)Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder caused by thymidine phosphorylase (TP) deficiency resulting in systemic accumulation of thymidine (d-Thd) and deoxyuridine ... -
Hfe H63D Mutation Frequency Shows An Increase In Turkish Women With Breast Cancer
(BioMed Central, 2006)Background The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. The association between cancer and HFE hetero- or homozygosity has previously been shown including hepatocellular and nonhepatocellular ... -
Lactobacillus Rhamnosus Could Inhibit Porphyromonas Gingivalis Derived Cxcl8 Attenuation
(Scientific Electronic Library Online, 2016)An increasing body of evidence suggests that the use of probiotic bacteria is a promising intervention approach for the treatment of inflammatory diseases with a polymicrobial etiology. P. gingivalis has been noted to have ... -
Expansion Of Human Umbilical Cord Blood Hematopoietic Progenitors With Cord Vein Pericytes
(Tubitak Scientific & Technical Research Council Turkey, 2017)The vascular niche is a site rich in blood vessels, whereas endothelial cells, pericytes, and smooth muscle cells create a microenvironment that recruits mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs), ... -
Cardiac Patch Design: Compatibility of Nanofiber Materials Prepared by Electrospinning Method with Stem Cells
(Tubitak Scientific & Technical Research Council Turkey, 2016)In this article, in order to create a cardiac patch, a biocompatible polyurethane (PU) nanofiber polymer was developed with the electrospinning method. Bone marrow mesenchymal stem cells (BM MSCs) were isolated from whole ... -
Evaluation Of Biocompatibility Of Random Or Aligned Electrospun Polyhydroxybutyrate Scaffolds Combined With Human Mesenchymal Stem Cells
(Tubitak Scientific & Technical Research Council Turkey, 2016)Polyhydroxybutyrate (PHB) is a polymer used to restore tissues or regenerate bones. However, its compatibility with human bone marrow-derived mesenchymal stem cells (MSCs) has not been examined. PHB membranes of random ... -
Enhancement of Mouse Hematopoietic Stem/Progenitor Cell Function Via Transient Gene Delivery Using Integration-Deficient Lentiviral Vectors
(Elsevier Science Bv, 2018)Integration-deficient lentiviruses (IdLVs) deliver genes effectively to tissues but are lost rapidly from dividing cells. This property can be harnessed to express transgenes transiently to manipulate cell biology. Here, ... -
Effects of Syzygium Aromaticum, Cinnamomum Zeylanicum, and Salvia Triloba Extracts on Proliferation and Differentiation of Dental Pulp Stem Cells
(Scielo, 2017)INTRODUCTION: Hypersensitivity, local irritative and cytotoxic effects are known for the chemical components of Syzygium aromaticum and Cinnamomum zeylanicum contained in dental materials. However, there is no intimate ...
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