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    • 18O-Assisted Dynamic Metabolomics for Individualized Diagnostics and Treatment of Human Diseases 

      Nemutlu, Emirhan; Zhang, Song; Juranic, Nenad O.; Terzic, Andre; Macura, Slobodan; Dzeja, Petras (2012)
      Technological innovations and translation of basic discoveries to clinical practice drive advances in medicine. Today's innovative technologies enable comprehensive screening of the genome, transcriptome, proteome, and ...

    • 18Th European Symposium On Radiopharmacy And Radiopharmaceuticals 

      Radchenko, V.; Engle, J. W.; Roy, C.; Griswold, J.; Nortier, M. F.; Birnbaum, E. R.; Brugh, M.; Mirzadeh, S.; John, K. D.; Fassbender, M. E.; Zhai, Chuangyan; Franssen, Gerben M.; Petrik, Milos; Laverman, Peter; Decristoforo, Clemens; Samia, Ait-Mohand; Véronique, Dumulon-Perreault; Brigitte, Guérin; Summer, D.; Kroess, A.; Rangger, C.; Haas, H.; Laverman, P.; Gerben, F.; von Guggenberg, E.; Decristoforo, C.; Bolzati, Cristina; Salvarese, Nicola; Refosco, Fiorenzo; Meléndez-Alafort, Laura; Carpanese, Debora; Rosato, Antonio; Saviano, Michele; Del Gatto, Annarita; Comegna, Daniela; Zaccaro, Laura; Billaud, Emilie; Ahamed, Muneer; Cleeren, Frederik; Shahbazali, Elnaz; Noël, Tim; Hessel, Volker; Verbruggen, Alfons; Bormans, Guy; Cleeren, F.; Lecina, J.; Koole, M.; Verbruggen, A.; Bormans, G.; Lugatoa, B.; Stucchia, S.; Turollaa, E. A.; Giulianoa, L.; Toddea, S.; Ferraboschib, P.; Klok, R. P.; Mooijer, M. P. J.; Hendrikse, N. H.; Windhorst, A. D.; Collet, C.; Petry, N.; Chrétien, F.; Karcher, G.; Pellegrini-Moïse, N.; Lamandé-Langle, S.; Pfaff, Sarah; Philippe, Cecile; Mitterhauser, Markus; Hacker, Marcus; Wadsak, Wolfgang; Guérard, François; Lee, Yong-Sok; Gouard, Sébastien; Baidoo, Kwamena; Alliot, Cyrille; Chérel, Michel; Brechbiel, Martin W.; Gestin, Jean-François; Lam, K.; Chan, C.; Reilly, R. M.; Paillas, Salomé; Marshall, John; Pouget, Jean-Pierre; Sosabowski, Jane; Briard, Emmanuelle; Auberson, Yves P.; Reilly, John; Healy, Mark; Sykes, David; Paulus, Andreas; Lichtenbelt, Wouter van Marken; Mottaghy, Felix; Bauwens, Matthias; Baranski, Ann-Christin; Schäfer, Martin; Bauder-Wüst, Ulrike; Haberkorn, Uwe; Eder, Matthias; Kopka, Klaus; Chaussard, M.; Hosten, B.; Vignal, N.; Tsoupko-Sitnikov, V.; Hernio, N.; Hontonnou, F.; Merlet, P.; Poyet, J. L.; Sarda-Mantel, L.; Rizzo-Padoin, N.; Cardinale, J.; Schäfer, M.; Benešová, M.; Bauder-Wüst, U.; Seibert, O.; Giesel, F.; Haberkorn, U.; Eder, M.; Kopka, K.; Nematallah, Mansour; Michel, Paquette; Samia, Ait-Mohand; Véronique, Dumulon-Perreault; Roger, Lecomte; Brigitte, Guérin; Fernandez-Maza, L.; Rivera-Marrero, S.; Capote, A. Prats; Parrado-Gallego, A.; Fernandez-Gomez, I.; Balcerzyk, M.; Sablon-Carrazana, M.; Perera-Pintado, A.; Merceron-Martinez, D.; Acosta-Medina, E.; Rodriguez-Tanty, C.; Attili, Bala; Ahamed, Muneer; Bormans, Guy; Philippe, C.; Zeilinger, M.; Scherer, T.; Fürnsinn, C.; Dumanic, M.; Wadsak, W.; Hacker, M.; Mitterhauser, M.; Janssen, B.; Vugts, D. J.; Molenaar, G.T. T.; Funke, U.; Kruijer, P. S.; Dollé, F.; Bormans, G.; Lammertsma, A. A.; Windhorst, A. D.; Vermeulen, Koen; Ahamed, Muneer; Schnekenburger, Michael; Froeyen, Mathy; Olberg, Dag Erlend; Diederich, Marc; Bormansa, Guy; Raaphorst, R. M.; Luurtsema, G.; Lammertsma, A. A.; Elsinga, P. H.; Windhorst, A D.; Rotteveel, Lonneke; Funke, Uta; ten Dijke, Peter; Bogaard, Harm Jan; Lammertsma, Adriaan A.; Windhorst, Albert D.; Song, Lei; Able, Sarah; Falzone, Nadia; Kersemans, Veerle; Vallis, Katherine; Carta, Davide; Salvarese, Nicola; Sihver, Wiebke; Gao, Feng; Pietzsch, Hans Jürgen; Biondi, Barbara; Ruzza, Paolo; Refosco, Fiorenzo; Bolzati, Cristina; Haubner, Roland; Finkensted, Armin; Stegmair, Armin; Rangger, Christine; Decristoforo, Clemens; Zoller, Heinz; Virgolini, Irene J.; Pooters, Ivo; Lotz, Maartje; Wierts, Roel; Mottaghy, Felix; Bauwens, Matthias; Forsback, Sarita; Jörgen, Bergman; Riikka, Kivelä; Karageorgou, M.; Radović, M.; Tsoukalas, C.; Antic, B.; Gazouli, M.; Paravatou-Petsotas, M.; Xanthopouls, S.; Calamiotou, M.; Stamopoulos, D.; Vranješ-Durić, S.; Bouziotis, P.; Lunev, A. S.; Larenkov, A. A.; Petrosova, K. A.; Klementyeva, O. E.; Kodina, G. E.; Kvernenes, O. H.; Adamsen, T. C. H.; Martin, René; Weidlich, Sebastian; Zerges, Anna-Maria; Gameiro, Cristiana; Lazarova, Neva; Müllera, Marco; Luurtsema, Gert; de Vries, Michèl; Ghyoot, Michel; van der Woude, Gina; Zijlma, Rolf; Dierckx, Rudi; Boersma, Hendrikus H.; Elsinga, Philip H.; Lambrecht, Fatma Yurt; Er, Ozge; Ince, Mine; Avci, Cıgır Biray; Gunduz, Cumhur; Sarı, Fatma Aslihan; Ocakoglu, Kasim; Er, Ozge; Ersoz, Onur Alp; Lambrecht, Fatma Yurt; Ince, Mine; Kayabasi, Cagla; Gunduz, Cumhur; Kniess, Torsten; Meister, Sebastian; Fischer, Steffen; Steinbach, Jörg; Ashfaq, Rabia; Iqbal, Saeed; ullah Khan, Irfan; Iglesias-Jerez, R.; Martín-Banderas, L.; Perera-Pintado, A.; Borrego-Dorado, I.; Farinha-Antunes, Ines; Kwizera, Chantal; Lacivita, Enza; Lucente, Ermelinda; Niso, Mauro; De Giorgio, Paola; Perrone, Roberto; Colabufo, Nicola A.; Elsinga, Philip H.; Leopoldo, Marcello; Vaulina, V. V.; Fedorova, O. S.; Orlovskaja, V. V.; Chen, ?�. L.; Li, G. Y.; Meng, F. C.; Liu, R. S.; Wang, H. E.; Krasikova, R. N.; Meléndez-Alafort, Laura; Abozeid, Mohamed; Ferro-Flores, Guillermina; Negri, Anna; Bello, Michele; Uzunov, Nikolay; Paiusco, Martha; Esposito, Juan; Rosato, Antonio; Meléndez-Alafort, Laura; Bolzati, Cristina; Ferro-Flores, Guillermina; Salvarese, Nicola; Carpanese, Debora; Abozeid, Mohamed; Rosato, Antonio; Uzunov, Nikolay; Palmieri, L.; Verbrugghen, T.; Glassner, M.; Hoogenboom, R.; Staelens, S.; Wyffels, L.; Orlovskaja, V. V.; Kuznetsova, O. F.; Fedorova, O. S.; Maleev, V. I.; Belokon, Yu. N.; Geolchanyan, A.; Saghyan, A. S.; Mu, L.; Schibli, R.; Ametamey, S. M.; Krasikova, R. N.; Revunov, Evgeny; Malmquist, Jonas; Johnström, Peter; Van Valkenburgh, Juno; Steele, Dalton; Halldin, Christer; Schou, Magnus; Osati, Samira; Paquette, Michel; Beaudoin, Simon; Ali, Hasrat; Guerin, Brigitte; Leyton, Jeffrey V.; van Lier, Johan E.; Di Iorio, V; Iori, M.; Donati, C.; Lanzetta, V.; Capponi, P. C.; Rubagotti, S.; Dreger, T.; Kunkel, F.; Asti, M.; Zhai, Chuangyan; Rangger, Christine; Summer, Dominik; Haas, Hubertus; Decristoforo, Clemens; Kijprayoon, Suphansa; Ruangma, Ananya; Ngokpol, Suthatip; Tuamputsha, Samart; Filp, Ulrike; Pees, Anna; Taddei, Carlotta; Pekošak, Aleksandra; Gee, Antony D.; Poot, Alex J.; Windhorst, Albert D.; Gunay, Mine Silindir; Ozer, A. Yekta; Erdogan, Suna; Baysal, Ipek; Guilloteau, Denis; Chalon, Sylvie; Galli, Filippo; Artico, Marco; Taurone, Samanta; Bianchi, Enrica; Weintraub, Bruce D.; Skudlinski, Mariusz; Signore, Alberto; Lepareur, Nicolas; Noiret, Nicolas; Hindré, François; Lacœuille, Franck; Benoist, Eric; Garin, Etienne; Trejo-Ballado, F.; Zamora-Romo, E.; Manrique-Arias, J. C.; Gama-Romero, H M; Contreras-Castañon, G.; Tecuapetla-Chantes, R. G.; Avila-Rodriguez, M. A.; Kvaternik, H.; Hausberger, D.; Zink, C.; Rumpf, B.; Aigner, R. M.; Kvaternik, H.; Hausberger, D.; Rumpf, B.; Aigner, R. M.; Janković, Drina; Lakić, Mladen; Savić, Aleksandar; Ristić, Slavica; Nikolić, Nadežda; Vukadinović, Aleksandar; Sabo, Tibor J.; Vranješ-Đurić, Sanja; Vranješ-Đurić, S.; Radović, M.; Janković, D.; Nikolić, N.; Goya, G. F.; Calatayud, P.; Spasojević, V.; Antić, B.; Goblet, David; Gameiro, Cristiana; Lazarova, Neva; Gameiro, Cristiana; Oxley, Ian; Abrunhosa, Antero; Kramer, Vasko; Vosjan, Maria; Spaans, Arnold; Vats, Kusum; Satpati, Drishty; Sarma, Haladhar D.; Banerjee, Sharmila; Wojdowska, W.; Pawlak, D. W.; Parus, L. J.; Garnuszek, P.; Mikołajczak, R.; Pijarowska-Kruszyna, J.; Jaron, A.; Kachniarz, A.; Malkowski, B.; Garnuszek, P.; Mikolajczak, R.; Ilem-Ozdemir, Derya; Caglayan-Orumlu, Oya; Asikoglu, Makbule; Ilem-Ozdemir, Derya; Caglayan-Orumlu, Oya; Asikoglu, Makbule; Eveliina, Arponen; Semi, Helin; Timo, Saarinen; Simo, Vauhkala; Esa, Kokkomäki; Pertti, Lehikoinen; De Simone, Mariarosaria; Pascali, Giancarlo; Carzoli, Ludovica; Quaglierini, Mauro; Telleschi, Mauro; Salvadori, Piero A.; Lam, Phoebe; Aistleitner, Martina; Eichinger, Reinhard; Artner, Christoph; Nakka, Surendra; MC, Hemantha Kumara; Al-Qahtani, Mohammed; Al-Qahtani, Mohammed; Al-Malki, Yousif; Mambilima, N.; Rubow, S. M.; Berroterán-Infante, N.; Hacker, M.; Mitterhauser, M.; Wadsak, W.; Funke, Uta; Cleeren, Frederik; Lecina, Joan; Gallardo, Rodrigo; Verbruggen, Alfons M.; Bormans, Guy; Ramos-Membrive, Rocío; Brotons, Ana; Quincoces, Gemma; Inchaurraga, Laura; de Redín, Inés Luis; Morán, Verónica; García-García, Berta; Irache, Juan Manuel; Peñuelas, Iván; Trabelsi, M.; Cooper, M. S.; Abella, Alejandra; Fuente, Teodomiro; Montellano, Antonio Jesús; Martínez, Teresa; Rabadan, Ruben; Meseguer-Olmo, Luis; Lehtiniemi, P.; Yim, C.; Mikkola, K.; Nuutila, P.; Solin, O.; von Guggenberg, E.; Rangger, C.; Mair, C.; Balogh, L.; Pöstényi, Z.; Pawlak, D.; Mikołajczak, R.; Socan, A.; Peitl, P. Kolenc; Krošelj, M.; Rangger, C.; Decristoforo, C.; Collet, C.; Remy, S.; Didier, R.; Vergote, T.; Karcher, G.; Véran, N.; Pawlak, D.; Maurin, M.; Garnuszek, P.; Karczmarczyk, U.; Mikołajczak, R.; Fredericia, Pil; Severin, Gregory; Groesser, Torsten; Köster, Ulli; Jensen, Mikael; Leonte, R.; Puicea, F. D.; Raicu, A.; Min, E. A.; Serban, R.; Manda, G.; Niculae, D.; Zerna, Marion; Schieferstein, Hanno; Müller, Andre; Berndt, Mathias; Yim, Cheng-Bin; Mikkola, Kirsi; Nuutila, Pirjo; Solin, Olof; Seifert, D.; Ráliš, J.; Lebeda, O.; Selivanova, Svetlana V.; Senta, Helena; Lavallée, Éric; Caouette, Lyne; Turcotte, Éric; Lecomte, Roger; Kochovska, Marina Zdraveska; Ivanovska, Emilija Janjevik; Jokic, Vesna Spasic; Ackova, Darinka Gjorgieva; Smilkov, Katarina; Makreski, Petre; Stafilov, Trajče; Janevik-Ivanovska, Emilija; Alemu, Aschalew; Muchira, Joel Munene; Wanjeh, David Mwanza; Janevik-Ivanovska, Emilija; Janevik-Ivanovska, Emilija; Zdravev, Zoran; Bhonsle, Uday; Alberto, Osso Júnior João; Duatti, Adriano; Angelovska, Bistra; Stojanovska, Zdenka; Sarafinovska, Zorica Arsova; Bosnakovski, Darko; Gorgieva-Ackova, Darinka; Smilkov, Katarina; Drakalska, Elena; Venkatesh, Meera; Gulaboski, Rubin; Colin, Didier J.; Inkster, James A. H.; Germain, Stéphane; Seimbille, Yann (2016)
      OP03 Selective extraction of medically-related radionuclides from proton-irradiated thorium targets, V. Radchenko, J.W. Engle, C. Roy, J. Griswold, M.F. Nortier, E.R. Birnbaum, M. Brugh, S. Mirzadeh, K. D. John, M.E. ...

    • 2,2,7,7-Tetra­Methyl-1,2,3,4,5,6,7,8-Octa­Hydro­Acridine-1,8-Dione 

      Öztürk Yildirim, Sema; Butcher, Ray J.; Şimsek, Rahime; El-Khouly, Ahmed; Şafak, Cihat (2012)
      The whole molecule of the title compound, C17H21NO2, is generated by twofold rotational symmetry. The N atom and the C and H atoms in position 4 of the pyridine ring lie on the twofold axis. The cyclohexene ring has a sofa ...

    • 3,3,6,6-Tetra­Methyl-9-(1-Methyl-1H-Indol-2-Yl)-1,2,3,4,5,6,7,8,9,10-Deca­Hydro­Acridine-1,8-Dione 

      Öztürk Yildirim, Sema; Butcher, Ray J.; El-Khouly, Ahmed; Safak, Cihat; Şimsek, Rahime (2012)
      In the acridine system of the title mol­ecule, C26H30N2O2, both cyclo­hex-2-enone rings adopt sofa conformations. The indole ring system is essentially planar, with a maximum deviation of 0.017 (2) Å for a bridgehead C ...

    • 9-(5-Bromo-1H-Indol-3-yl)-1,2,3,4,5,6,7,8,9,10-Deca­hydro­acridine-1,8-Dione Dimethyl Sulfoxide Monosolvate 

      El-Khouly, Ahmed; Öztürk Yildirim, Sema; Butcher, Ray J.; Şimsek, Rahime; Şafak, Cihat (2012)
      In the title compound, C21H19BrN2O2·C2H6OS, the indole ring system is essentially planar, with a maximum deviation of 0.050 (3) Å for the non-bridgehead C atom adjacent to the N atom. The two cyclo­hex-2-enone rings adopt ...

    • A Method to Determination of Lead Ions In Aqueous Samples: Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction Method Based on Solidification of Floating Organic Drop and Back-Extraction Followed By Faas 

      Arpa, Çiğdem; Aridaşir, Itır (2018)
      Ultrasound-assisted dispersive liquid-liquid microextraction method based on solidification of floating organic drop and back-extraction (UA-DLLME-SFO-BE) technique was proposed for preconcentration of lead ions. In this ...

    • A New Generation Of Dihydropyridine Calcium Channel Blockers: Photostabilization Of Liquid Formulations Using Nonionic Surfactants 

      Ioele, Giuseppina; Gündüz, Miyase Gözde; Spatari, Claudia; De Luca, Michele; Grande, Fedora; Ragno, Gaetano (2019)
      The stability profile of a new 1,4-dihydropyridine derivative (DHP), representative of a series with a hexahydroquinoline ring, was studied to design light-stable liquid formulations. This molecule, named M3, has been shown ...

    • A New Perspective On Evaluation Of Medicinal Plant Biological Activities: The Correlation Between Phytomics And Matrix Metalloproteinases Activities Of Some Medicinal Plants 

      Gonulalan, Ekrem-Murat; Nemutlu, Emirhan; Demirezer, Lutfiye-Omur (2019)
      Phytomics or metabolomics is analysis of large-scale primary and secondary metabolites of plant extracts and provides very meaningful data to monitor or evaluate cellular function or systems biology. The activity of plant ...

    • Aloe-Emodin As Drug Candidate For Cancer Therapy 

      Özenver, Nadire; Saeed, Mohamed; Demirezer, Lütfiye Ömur; Efferth, Thomas (2018)
      As a leading cause of global mortality, cancer frequently cannot be cured due to the development of drug resistance. Therefore, novel drugs are required. Naturally occurring anthraquinones are mostly present in Rumex and ...

    • Altered Hdl Particle In Sickle Cell Disease: Decreased Cholesterol Content Is Associated With Hemolysis, Whereas Decreased Apolipoprotein A1 Is Linked To Inflammation 

      Yalcinkaya, Ahmet; Unal, Selma; Oztas, Yesim (2019)
      Background Hypocholesterolemia is the most frequently encountered lipid abnormality in sickle cell disease (SCD). We enrolled pediatric patients to determine the relationships between lipid profile and parameters of ...

    • An Overview on Dry Eye Treatment: Approaches for Cyclosporin A Delivery 

      Yavuz, Burçin; Bozdağ Pehlivan, Sibel; Ünlü, Nurşen (2012)
      Dry eye syndrome (DES, Keratoconjunctivitis sicca) is a common disorder of the tear film caused by decreased tear production or increased evaporation. Changes in tear composition also promote inflammation on the ocular ...

    • Analysis Of The Antiproliferative Effect Of Ankaferd Hemostat On Caco-2 Colon Cancer Cells Via Lc/Ms Shotgun Proteomics Approach 

      Koçak, Engin; Çelebier, Mustafa; Haznedaroglu, Ibrahim C.; Altınöz, Sacide (2019)
      Ankaferd hemostat (ABS), a traditional herbal extract, is a hemostatic agent used for wound healing and bleeding treatment. A standardized form of plants contains many biomolecules. In recent years, previous studies have ...

    • Anti-Cancer Effects of 3,5-Dimethylaminophenol in A549 Lung Cancer Cells 

      Lin, Pei-Ying; Chang, Yu-Jung; Chen, Yu-Chen; Lin, Chin-Hung; Erkekoglu, Pinar; Chao, Ming-Wei; Tseng, Chia-Yi (2018)
      Exposure to 3,5-dimethylaminophenol (3,5-DMAP), the metabolite of the 3-5-dimethylaniline, was shown to cause high levels of oxidative stress in different cells. The aim of the present work was to observe whether this ...

    • Antigenotoxic Properties of Paliurus Spina-Christi Mill Fruits and Their Active Compounds 

      Zor, Murat; Aydin, Sevtap; Güner, Nadide Deniz; Başaran, Nurşen; Başaran, Arif Ahmet (2017)
      Background Paliurus spina-christi Mill. (PS) fruits are widely used for different medical purposes in Turkey. Like in many medicinal herbs the studies concerning their activity, the activities of PS are also not well ...

    • Antioxidant Sme1Ec2 Modulates Pentose Phosphate Pathway and Glutathione-Dependent Enzyme Activities in Tissues of Aged Diabetic Rats 

      Ulusu, Nuray Nuriye; Gök, Müslüm; Sayin Şakul, Arzu Ayşe; Ari, Nuray; Stefek, Milan; Karasu, Çimen (2017)
      The pentose phosphate pathway and glutathione-associated metabolism are the main antioxidant cellular defense systems. This study investigated the effects of the powerful antioxidant SMe1EC2 (2-ethoxycarbonyl-8-methoxy-2 ...

    • Antiviral Properties Of Caffeic Acid Phenethyl Ester And Its Potential Application 

      Erdemli, Hacı Kemal; Akyol, Sumeyya; Armutcu, Ferah; Akyol, Omer (2015)
      Caffeic acid phenethyl ester (CAPE) is found in a variety of plants and well-known the active ingredient of the honeybee propolis. CAPE showed anti-inflammatory, anticarcinogenic, antimitogenic, antiviral, and immunomodulatory ...

    • Assessing Medical Prescription Forms As A Communication Tool In Trans-European Health Care 

      Cavaco, Afonso Miguel; Mourato, Miguel; Ferreira, Sofia; Yeğenoğlu, Selen (2018)
      Objective: The objective of the study was to compare the medical prescription forms in European Union (EU) countries, evaluating their convergence toward the implementation of cross-border care, as proposed by the existing ...

    • Bone Resorption, Matrix Metalloproteinases and Caffeic Acid Phenethyl Ester 

      Akyol, Sumeyya; Kursunlu, S. Fatih; Akyol, Omer (2016)

    • Caffeic Acid Phenethyl Ester As a Protective Agent Against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review 

      Akyol, Sumeyya; Ugurcu, Veli; Altuntas, Aynur; Hasgul, Rukiye; Cakmak, Ozlem; Akyol, Omer (2014)
      Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, ...

    • Caffeic Acid Phenethyl Ester As A Remedial Agent For Reproductive Functions And Oxidative Stress-Based Pathologies Of Gonads 

      Akyol, Sumeyya; Akbas, Ali; Butun, Ilknur; Toktas, Muhsin; Ozyurt, Huseyin; Sahin, Semsettin; Akyol, Omer (2015)
      In recent years, the studies on the roles of caffeic acid phenethyl ester (CAPE) in several disease models and cell cultures are tremendously growing. It is such a great molecule that was used by ancient times to ameliorate ...