Effects Of Local Alendronate Administration On Bone Defect Healing. Histomorphometric And Radiological Evaluation In A Rabbit Model

Date
2017Author
Ozer, Taha
Akta, Alper
Bari, Emre
Celik, Hakan Hamdi
Vatansever, Alper
- Citations
- CrossRef - Citation Indexes: 2
- PubMed - Citation Indexes: 2
- Scopus - Citation Indexes: 9
- Usage
- SciELO - Full Text Views: 1485
- SciELO - Abstract Views: 112
- Captures
- Mendeley - Readers: 26
publications
0
supporting
0
mentioning
0
contrasting
0
0
0
0
0
Citing PublicationsSupportingMentioningContrasting
See how this article has been cited at scite.ai
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
xmlui.mirage2.itemSummaryView.MetaData
Show full item recordAbstract
Purpose: To performed a histomorphometric and radiological study to evaluate the effects of alendronate sodium administered locally in mandibular bone defects created in rabbits. Methods: Two circular defects 5 mm in diameter were created bilaterally in the mandibular corpus of 20 New Zealand rabbits (i.e., four defects per animal). Each defect received one of four treatments: no treatment (EC group), alendronate irrigation (AL group), autogenous bone grafting (AG group), or alendronate irrigation with autogenous bone grafting (AL+AG group). Histomorphometric and radiological assessments were conducted at 4 and 8 weeks after surgery. Results: Between-group comparisons of the new bone area, the value of the AL+AG group was significantly lower thanthe remaining three groups at 4 weeks postoperatively. In all groups, the new bone area was significantly larger at 8 weeks than at 4 weeks. The residual graft area at 4 and 8 weeks was significantly higher in the AL+AG group than in the AG group, although it was significantly smaller at 8 weeks than at 4 weeks in both these groups. Conclusion: The use of alendronate sodium in conjunction with autogenous bone grafting improves the osteoconductive properties of the graft, enhances graft retention in the defect, and improves ossification.