Renin-Angiotensin System Expression in the K562 Human Erythroleukaemic Cell Line
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Tarih
2007Yazar
Koca, Ebru
Haznedaroglu, Ibrahim C.
Acar, Kadir
Beyazit, Yavuz
Aksu, Salih
Misirlioglu, Muge
Tuncer, Serdar
Sayinalp, Nilgun
Ozcebe, Osman I.
Uner, Aysegul
Üst veri
Tüm öğe kaydını gösterÖzet
Local renin-angiotensin system (RAS) may affect leukaemic cell production within the bone marrow microenvironment. Angiotensin-converting enzyme (ACE), renin, and angiotensin could influence leukaemogenesis. In this study, mRNA expressions of the major RAS components (ACE, renin, and angiotensinogen) in K562 human erythroleukaemia cell line have been searched by Real Time quantitative polymerase chain reaction. K562 blasts are multipotential, haematopoietic malignant cells that spontaneously differentiate into recognisable progenitors of the erythrocyte, granulocyte and monocytic series. We observed significant expressions of ACE, renin, and angiotensinogen in K562 leukaemic blast cells. Therefore, K562 human erythroleukaemia cell line may serve as an in vitro model to elucidate the role of RAS in leukaemia and to test the effects of RAS-affecting drugs on leukaemic cellular proliferation.