Cystic Echinococcosis (CE) is a zoonotic infectious disease caused by the larval form of Echinococcus granulosus sensu lato. The life cycle of the parasite continues between definitive hosts, which are domestic/wild carnivores, and intermediate hosts, which are herbivorous animals; humans become involved in this cycle incidentally. The diagnosis of CE is made using non-invasive imaging techniques such as ultrasonography, computed tomography, X-ray, and magnetic resonance imaging. With the discovery of disease-specific miRNAs, the expression levels of miRNAs have been extensively studied in diseases where diagnosis and monitoring are challenging. Many parasite-derived miRNAs are expressed in the egg, metacestode, and adult forms involved in the life cycle of E.granulosus. The aim of this study is to examine the expression levels of parasite-derived miRNAs, egr-miR-2a-3p and egr-miR-277b, by comparing cystic echinococcosis (CE) patients and healthy controls, to determine the diagnostic specificity and sensitivity of these molecules, and to compare them with serological tests.