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Toplam kayıt 11, listelenen: 1-10
Kemik İliği Yağ Tabakasından Elde Edilen Mezenkimal Kök Hücrelerin Karakterizasyonu ve Subkutan Yağ ve Kemik İliği Kökenli Mezenkimal Kök Hücreleri ile Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2020-09)
Bone marrow adipose tissue (BMAT) has different properties than other adipose tissues. Recent studies have shown the effects of bone marrow adipose tissue on development / progression of acute myeloblastic leukemia (AML), ...
Mezenkimal Kök Hücre Yaşlanmasında Nf-Κb/P65 ve Pknox2 Protein-Protein Etkileşimlerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2021)
Mesenchymal stem cells undergo replicative senescence by cultivating in vitro and as the passage extends they lose their stem cell properties. Previous study of our group investigating proteomics of the co-immunoprecipitated ...
Apc Mutant Fare İntestinal Organoidlerinde Wnt Yolak Modülasyonunun Kök Hücreler Üzerine Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2022)
One of the most important causes of colorectal cancer development is mutations of genes involved in the WNT signaling pathway. In the vast majority of cases, APC tumor suppressor gene mutations, which act as negative ...
Podosit Hasar Modelinde İndüklenmiş Mezenkimal Kök Hücrelerinin Etkisi
(Sağlık Bilimleri Enstitüsü, 2023-02-08)
Sahan, OB., The Effect of İnduced Mesenchymal Stem Cells On Podocyte Injury Model, Hacettepe University Graduate School of Health Sciences Department of Stem Cell Sciences Doctor of Philosophy Thesis, Ankara,2023. Self-renewal, ...
Nörofibromatozis Tip 1(Nf1) Kaynaklı Mezenkimal Stromal Hücrelerin Detaylı Karakterizasyonu
(Sağlık Bilimleri Enstitüsü, 2022-10-07)
Neurofibromatosis type 1 (NF1) is an inherited autosomal dominant disease characterized by mutation in the neurofibromin (NF1) tumor suppressor gene. The lack of neurofibromin, the gene product, causes defects in the nervous ...
Kemik İliği Mezenkimal Kök Hücrelerinde p53 Yolağı Regülasyonunda PKNOX2 ve Etkileşimlerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2023)
Mesenchymal Stem Cells (MSC) are good platforms to study in-vitro molecular mechanisms. Like all cells, MSCs detect and respond to various stimuli with molecular signal mechanisms. p53 signal pathway is a well-known molecular ...
Hematopoetik Kök Hücre Gen Tedavi Kültür Koşulları ve Engraftman Optimizasyonu
(Sağlık Bilimleri Enstitüsü, 2021)
RAG2 severe combined immunodeficiency (SCID) is a rare, inherited primary immunodeficiency (PID), characterized by a T-/B-/NK+ phenotype and is treated with hematopoietic stem cell (HSC) transplantation. When no suitable ...
Mikrorna-21 Baskılanmış Meme Kanseri Kök Hücrelerinin İnsan Kemik İliğinden İzole Edilen Telositler ve Telosit Kaynaklı Mitokondriler ile Ko-Kültürü
(Sağlık Bilimleri Enstitüsü, 2023)
The aim of this thesis study was to investigate the contribution of telocytes and telocyte-derived mitochondria, which have also been identified in breast tumours, to the tumour development of breast cancer stem cells via ...
İnsan somatik hücrelerinin uyarılmış plüripotent kök hücrelere yeniden programlanması sürecinde arilhidrokarbon reseptörü sinyalizasyonundaki değişimlerin incelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)
Sevindi S., Investigation of Changes in Arylhydrocarbon Receptor Signaling in the Reprogramming of Human Somatic Cells into Induced Pluripotent Stem Cells, Hacettepe University Graduate School of Health Sciences Department ...
Oksidatif Stres Altında Mezenkimal Kök Hücrelerde Src-YAP Aktivitesi ve Apoptoz ile İlişkisi
(Sağlık Bilimleri Enstitüsü, 2024)
One of the reasons for the post-transplantation loss of mesenchymal stem cells (MSCs), which are used in the treatment of many diseases with their immunomodulatory and regenerative properties, is oxidative stress-induced ...