Browsing Biyoinformatik by Issue Date
Now showing items 1-12 of 12
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Bayesian Networks for Omics Data Analysis in Hepatocellular Carcinoma Single-Cell Sequencing
(Sağlık Bilimleri Enstitüsü, 2021)Single cell multi omics techniques have shown an advancement in unrevealing complex diseases like cancer heterogeneity by providing multi-faceted insight into their individual cellular regulations. In this study, a machine ... -
Dört Farklı Kansere Ait Transkriptom Verisinin In Sılıco Karşılaştırılması ve Pankreas Kanserine Özgü Biyobelirteç Adaylarının Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2021-02-23)Pancreatic cancer is the 11th most common cancer worldwide. Five-year survival of lung, colon and stomach cancers, which are the top three in cancer related deaths, are 19%, 65% and 20%, respectively. Although pancreatic ... -
Yapay Öğrenme Bazlı Hesaplamalı Modelleme İle Geniş Çaplı Kanser Hücre Hattı İlaç Yanıt Tahmini
(Sağlık Bilimleri Enstitüsü, 2022)Assessing the best treatment option specifically for each patient is the main goal of precision medicine. The patients with the same diagnosis may display varying sensitivity to the applied treatment due to genetic ... -
Kişiselleştirilmiş Sağkalım Tahmini İçin Geniş Çaplı Kanser Verisinin Yapay Öğrenme ve Çoklu-Omik Bazlı Analizi
(Sağlık Bilimleri Enstitüsü, 2022)Cancer is one of the leading causes of death worldwide. The high lethality of some of the sub-types of cancer increases the importance of correct diagnosis, complete follow-up and effective treatment. Survivability in ... -
Frontonazal Nadir Bir Yüz Malformasyonu ile İlişkili Aday Genlerde Protein Düzeyinde In Silico Analiz
(Sağlık Bilimleri Enstitüsü, 2022)Frontonasal malformations are diseases that develop in the median facial line and appear in variable phenotypic features. A family of 5 affected and 2 unaffected individuals were studied by microarray and whole-exome ... -
Automated Design vf Drug Candidate Molecules with Deep Graph Learning
(Sağlık Bilimleri Enstitüsü, 2023)The discovery of new drug candidate molecules is an important step in the process of drug development. Deep generative learning, a frequently used approach in the field of artificial intelligence in recent years, has emerged ... -
Mikrodizin kaynaklı genotip bilgisi kullanılarak kopya sayısı değişikliklerinde mozaiklik oranının saptanması
(Sağlık Bilimleri Enstitüsü, 2023)Acun, H. M., Determination of Mosaicism Ratio in Copy Number Variations Using Microarray Based Genotype Information, Hacettepe University Graduate School of Health Sciences Department of Bioinformatics Master’s Thesis, ... -
Kompleks Hastalıklarla İlişkili Genetik Varyasyonun Zaman-Serisi Genom Dizileme Verilerinde Popülasyon Genetiği Yaklaşımları ile İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023-06-19)Genetic diseases are the products of evolutionary process. The demographic history of anatomically modern humans over the last 200.000 years has shaped the genetic structure associated with common diseases. It is possible ... -
Heterojen Biyomedikal Verinin Bilgi Çizgeleri ve Derin Öğrenme Tabanlı Analizi ile Protein Fonksiyonlarının Otomatik Tahmini
(Sağlık Bilimleri Enstitüsü, 2023-07-31)Proteins are vital for cellular processes, and accurately determining their functions is crucial for understanding complex biological mechanisms. Computational approaches have emerged as alternatives to expensive and ... -
Anadolu'daki Nadir Otoinflamatuvar Hastalıklar ile İlişkili Mutasyonlar için Alel Yaşının Hesaplanması
(Sağlık Bilimleri Enstitüsü, 2024)Autoinflammatory diseases are diseases that emerge from the abnormalities in the innate immune system of the individuals. In the crisis times, one of the mostly seen symptom is the high amount of inflammation biomarkers. ... -
Image, Sequence, and Interactome Based Prediction of Subcellular Localization of Proteins
(Sağlık Bilimleri Enstitüsü, 2024-01-31)Knowledge of subcellular localization (SL) of proteins is essential for drug development, systems biology, proteomics, and functional genomics. Due to the high costs associated with experimental studies, it has become ... -
Genotip İmpütasyonunun Antik Anadolu İnsan Genomlarında Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2024-06-14)Genotype imputation presents a solution to the high amount of missing information in low coverage ancient DNA samples. In this thesis, by using the phasing and imputation tool GLIMPSE, the accuracy of genotype imputation ...
