Rozasealı Hastalarda Vasküler Endotelyal Büyüme Faktör Polimorfizminin Araştırılması

Abstract

Rosacea is a chronic inflammatory skin disease. Its pathogenesis remains unclear, but many studies suggest a vascular etiology. Vascular endothelial growth factor is an endothelial specific growth factor which plays an important role in angiogenesis, vascular permeability and inflammation. In studies investigating the role of VEGF in pathogenesis of rosacea, increased expression of VEGF and its receptors have been detected. We investigated VEGF (+405 C G), VEGF (-460T C), VEGF (-1540C A), VEGF (-1451C T) and VEGF (-1512Ins18) polymorphisms and serum level of VEGF, VEGR-1, VEGFR-2 in patients with rosacea. 100 rosacea patients and 100 age and sex-matched controls were included in the study. Demographic and clinical features of the patients were recorded. Blood and serum samples were collected. PCR and gel electrophoresis is used to detect VEGF polymorphism and serum VEGF, VEGFR1, VEGFR2 levels were analyzed with ELISA. % 77 of the patients were female, % 23 were male. Mean of age was 44