Obstruktif Uyku Apne Sendromunda Cpap Tedavisinin Pulmoner Fonksiyon, Anksiyete/Depresyon ve Yaşam Kalitesi Üzerine Etkisi

Abstract

Obstructive sleep apnea syndrome (OSAS) is a condition commonly associated with excessive daytime sleepiness and neurophysiological dysfunction and increases cardiovascular and cerebrovascular morbidity and mortality. Continuous airway pressure (CPAP) therapy is the mainstay of OSAS; Stimulates collapse of the upper airway during sleep and improves the quality of life by reducing the tendency to sleep during the day by dividing the sleep. Exercise limitation was assessed with a 6-min walk test (6MWT) in previous studies and was associated with apnea hypopnea index (AHI), body mass index (BMI), female gender, hypertension (HT), and low FVC values. There are few studies on the effect of CPAP treatment on these parameters. In our study; The aim of this study was to evaluate the changes in pulmonary function test (PFT), 6MWT, quality of life (SF-36) and hospital anxiety / depression scale with patients who should use CPAP because of OSAS.

18 patients were included in the study. These patients; 17% were female and 83% were male and the mean age was 46.9 ± 9. The anxiety and depression scores were significantly decreased after one month of CPAP treatment. Before CPAP treatment; anxiety was found in 4 patients and depression was found in 8 patients. One month CPAP treatment; anxiety was present 2 patients and no depression was detected in any patient. In the evaluation of exercise capacity; there was a significant increase in walking distance after CPAP treatment (548,83 ± 60,6, 579,33 ± 54) (p: 0,007). CPAP treatment was significantly improved in subscales of quality of life in general health, physical function, vitality (energy), social function and mental health sub-parameters. There was no significant change in spirometric measurements before and after CPAP treatment and titration. There was no significant change in spirometric measurements before and after CPAP treatment and titration. In the correlation analysis, a significant relationship was found between the change in 6MWT and the change in physical function, energy, mental health and anxiety score. At the same

time, a significant correlation was found between anxiety and depression improvement and quality of life subscales.

İn conclusion; OSAS causes exercise limitation, quality of life, and impairment of anxiety / depression parameters. CPAP therapy in OSAS patients shows improvement in exercise capacity, anxiety / depression moods and quality of life sub-parameters.