Maternal Dönemde Kafeterya Diyeti ve Taurin Suplementasyonunun Laktasyon Sonundaki Bazı Plazma Parametrelerine Etkisi
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Date
2019Author
Alkan Tuğ, Tuğba
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The aim of this study was to investigate the effect of exposure to maternal consumption of cafeteria diet on maternal adaptation to pregnancy, maternal plasma glucose, total cholesterol, triglycerides, insulin concentration, plasma free amino acid profile at weaning and whether taurine suplementation affects the adaptation to pregnancy and plasma parameters. Twenty seven, 3 weeks old virgin female Wistar rats were randomized to four groups during pre-pregnancy (8 weeks), pregnancy and lactation; Control group (CON, n=6): standard chow, taurine group (CONT, n=7): CON supplemented with 1.5% taurine in drinking water, cafeteria group (CAF, n=7): standard chow and cafeteria diet, cafeteria+taurine group (CAFT, n=7): CAF supplemented with taurine. Maternal food intake and body weight were recorded daily. All dams were euthanized at the end of lactation and blood samples were taken. Plasma glucose, total cholesterol, triglycerides, insulin levels were assessed via ELISA while free amino acid profile with EZ:faast amino acid kit by GC (gas chromatography). It was determined that rats fed with cafeteria diet (CAF and CAFT) had a greater weight gain during the pre-pregnancy and pregnancy period compared to the CON group (pre-pregnancy; diet factor: p<0.001, week factor: p<0.001, interaction: p>0.05 pregnancy; diet factor: p<0.05, week factor: p<0.001, interaction: p>0.05). Food intake of CAF and CAFT groups were much more than CON group and this was found statistically important (pre-pregnancy; diet factor: p<0.001, week factor: p<0.001, interaction: p<0.001, pregnancy; diet factor: p<0.001, week factor: p<0.05, interaction: p>0.05; lactation; diet factor: p<0.001, week factor: p<0.001, interaction: p<0.05). There were no differences between groups in maternal plasma glucose, total cholesterol, triglycerides, insulin concentration at the end of lactation (p>0.05). While free alfa-aminobutyric acid, serine, aspartic acid, alfa-amino pimelic acid concentrations in plasma of CAF and CAFT dams were significantly higher, plasma free phenyl alanine and tyrosine concentrations were significantly lower in group CON (p<0.05). There were no differences between CAF and CAFT groups in body weight, food intake and plasma parameters (p>0.05). Consequently, maternal cafeteria diet had an important effect on maternal adaptation to pregnancy and plasma free amino acid profile of dams but there was no effect of taurine supplementation. Further comprehensive studies are required in order to assess long term metabolic and physiological effects of maternal cafeteria diet and taurine on metabolism.