Propil Parabenin Olgunlaşmamış Erkek Sıçanlardaki Antiandrojenik Etkilerinin Araştırılması

Abstract

With the effects of developing industrial industry, one of the most used paraben class; the propyl paraben (propyl 4-Hydroxybenzoate), is widely used in many products because of their low toxicity, physical and chemical stability, wide spectrum activity, worldwide admitted applications, biosolubility, preventing from mold and yeast and their low cost. In this study it will undertake to understand the antiandrogenic effects of propyl paraben on the 6-weeks old castrated male Wistar albino rats. Due to aim of investigating the antiandrogenic effects of propyl paraben on the male reproductive tracts, the 10-days Hershberger Bioassay has chosen. After the 10-days treatment period, the evaluation of weights of accessory tissues of the male reproductive tracts, body and weights plus food and water consumption were recorded. The LH and FSH hormone levels and hematologic results had also analyzed. As a result of the comparative analytical studies, there was a decrease in androgenic tracts and liver tissues weights, increase in serum LH levels and atrophic aspects on histopathological endpoints on 250 mg/kg/day of propyl paraben dose. These specific findings strongly indicate that propyl paraben, an antimicrobial preservative, has an antiandrogenic activity.