Polikistik Over Sendromlu ve Sağlıklı Kadınlarda Bağırsak Mikrobiyota Üyelerinden Prevotella Melaninogenica, Ruminococcus Torques ve Clostridium Difficile Karşılaştırılması

Abstract

Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy characterized with hyperandrogenism, oligo-anovulation and polycystic ovaries. Dysbiosis of intestinal microbiota is associated with diabetes, obesity and several metabolic disorders. However, limited data is available regarding potential relationship between PCOS and intestinal microbiota. In this pilot study, intestinal microbiota members Prevotella melaninogenica, Ruminococcus torques and Clostridium difficile were compared quantitatively in 25 reproductive aged patients with PCOS and normal body weight and 25 healthy, BMI-matched women. As compared to healthy control group, the amount of Prevotella Melaninogenica was significantly higher in PCOS group (6.50 ± 0.27 log10 / gram stool, 5.81 ± 0.19 log10 / gram stool; p = 0.04). Significant positive correlation was found between Prevotella melaninogenica and testosterone levels (Pearson r=0.28; p=0.04). No significant difference was found between PCOS and control groups for the amount of a Ruminococcus torques and Clostridium difficile. These results suggest a potential relationship between PCOS and Prevotella melaninogenica possibly through androgen excess.