İnsan Kaynaklı Kistik Ekinokokkozis'in Moleküler Epidemiyolojisi

Abstract

Cystic Echinococcosis (CE) is a zoonotic disease caused by larval forms of parasites of the genus Echinococcus in humans. CE is one of the most common zoonotic diseases in the world, particularly in regions where the local population is active with animal breeding, being in close contact with sheep, cattle and dogs. Members of the Echinococcus circulate between domestic / wild carnivores and herbivores, and humans become incidental hosts. The genus includes mainly 4 species which comprise E.granulosus, E.multilocularis, E.oligarthrus and E.vogeli. Significant genetic variability has been demonstrated on CE agents and has been associated with life cycle and host specificity. According to recent findings, E.granulosus complex are divided into 10 genotypes (G1-G10). The proposed study aims to determine the genotypes of E.granulosus isolates, detected in CE cases from endemic regions including Turkey and various Eastern European countries and investigate the epidemiology and impact of genotypes on clinical progress.