3-Aminopropiltrietoksisilan (APTS) ile Modifiye Polimer/Halloysit Nanotüplerinin Tasarımı, Sentezi ve Karakterizasyonu

Abstract

In this thesis study; design, synthesis and characterization of poly (maleic anhydride-alt-acrylic acid) with biological activity and polymer/clay nanocomposites to be aimed. Poly (MA-alt-AA) was synthesized by complex radical copolymerization via charge transfer complex (CTC). Surface modification of halloysite nanotubes (HNT) with 3-aminopropyltriethoxysilane (APTS) was performed to obtain organic functionalized halloysite. Nanocomposite materials were obtained in nanotube form by in situ solution complex copolymerization via charge transfer (CTC) under conditions of copolymerization, using pure halloysite and APTS functionalized halloysite nanotubes, acrylic acid (AA) and maleic anhydride (MA) monomers. Optimization study using different clay ratios and recipe for organic-inorganic compatibility. Characterization studies of hallyosite, modified halloysite, copolymers and the formed copolymer-HNT nanotubes have been done using spectroscopic analyzes (XRD, ATR-FTIR, HR-Raman, XPS), thermal analysis (TGA), dynamic mechanical properties (DMA) and surface morphology with Transmission Electron Microscopy (TEM). The obtained poly (MA-alt-AA)/halloysite and poly (MA-alt-AA)/modified halloysite nanotubes were drug conjugated with 5 fluorouracil (5-FU) used as a cancer therapy agent. ATR-FTIR, HR-Raman, XRD, DMA, TGA and TEM methods were used for the characterization of synthesized polymer / clay nanotubes and drug conjugates.