İskelet Kasında Tüm Vücut Titreşimi ve Immobilizasyonun Protein Sentez ve Yıkımında Rol Oynayan Sinyal Yolakları Üzerine Etkisi

Abstract

In addition to disuse such as immobilization, denervation and hindlimb suspension, some physiologic and pathologic conditions result in skeletal muscle atrophy. Although atrophy is an important clinical problem, there are no known therapeutic interventions. Recently, there is a growing interest on Whole Body Vibration (WBV) which has shown to increase muscle mass, strength and balance. The molecular mechanisms of the effect of WBV on skeletal muscle are unknown. This study was designed to elucidate the effects of immobilization, remobilization and WBT on signaling pathways involved in muscle atrophy and hypertrophy. Four months old female Wistar Albino rats randomly divided to five groups (n=6 each group): Control (C), two weeks of immobilization (I), immobilization followed by one week of remobilization (IR), immobilization followed by one week of remobilization and WBV (IRV) one week of WBV (WBV).