Kan Filtrasyon Uygulamaları İçin Titanyum Dioksit Nanotüp Tabanlı Membran Sistemlerinin Üretimi ve Karakterizasyonu

Abstract

Due to high biocompatible properties, titanium dioxide nanotube surface arrays have widely been used in orthopedic and dental implants, biosensor and drug releasing systems. In the presented thesis study, titania nanotube-based membrane structures, which preserving its bulk stability, had been fabricated by three-step electrochemical anodic oxidation and sudden change in application potential at different temperatures. Availability of fabricated titania nanotube-based membrane structures at blood filtration applications were investigated for wearable/portable and implantable artificial kidneys; their chemical and morphological properties had been determined by scanning electron microscopy (SEM), energy dispersive x-ray analysis (EDX), x-ray diffraction analysis (XRD), water contact angle (WCA) and atomic force microscopy (AFM). In this aim, uremic toxin filtration performances of these nanostructures had been tested in the flow cells which had been manufactured with 3D printing by modernized fused deposition modelling technology of poly(ethlyene tereftalat – gyclycol) (PETG). Two different membrane structures, which having nanotubes with 50 nm radius and 30 µm length on 36% of their surfaces, had been investigated for crossflow pure water flux (PWF), rates of creatinine clearance and bovine serum albumin (BSA) rejection. The nanoceramic ultrafiltration membranes shows 95% in creatinine clearance and 20% in BSA rejection due to negative repulsive electostatic forces in the blood filtration application which being claimed appliable as the results of digital and experimental failure analysis.