Klinik Ve Radyolojik Olarak Diz Osteoartriti Tanısı Almış Olan Hastalarda Serum Comp ve Mmp-3 Düzeylerinin Hastalık Evresi ve Günlük Yaşam Aktiviteleri ile İlişkisi

Abstract

Introduction: Osteoarthritis is the most common joint disease affecting the knee joints mostly. The incidence is increasing and it significantly affects the quality of life by causing significant morbidity especially in the second half of life. In recent years, a multifactorial disease with low-grade chronic inflammation is considered to play a role in the pathogenesis of osteoarthritis. The aim of this study is to investigate the relationship between serum COMP (Cartilage Oligomeric Matrix Protein) and MMP-3 (Matrix Metalloproteinase-3) levels and disease stage and daily life activities in patients diagnosed with knee osteoarthritis.

Materials and Methods: A total of 85 patients who were diagnosed with knee osteoarthritis according to ACR (American College of Rheumatology) criteria and had been admitted to Hacettepe University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, were included to the study. Patients' age, gender, weight, height, educational background, occupation, additional diseases and medications were recorded. Knee osteoarthritis was evaluated by performing a detailed physical examination. In addition, blood samples were taken from patients for serum COMP and MMP-3 measurements. The severity of pain in patients and functional status in daily life activities were evaluated with VAS (Visual Analog Scale), WOMAC (The Western Ontario and McMaster Universities Osteoarthritis Index), Lequesne and KOOS-PS (Knee Injury and Osteoarthritis Outcome Score Short Form) scales.

Results: Seventy-five (88.2%) of the patients were female and ten (11.8%) were male. 85 patients were divided into 3 groups according to the Kellgren-Lewrence radiological staging system (K-L). K-L stage I patients were included in group 1, patients with K-L stage II and III were included in group 2, and patients with K-L stage IV were included in group 3. The mean age was 57.17 ± 9.37 in group 1, 64.73 ± 9.48 in group 2, and 68.17 ± 10.27 years in group 3. In our study, serum COMP and MMP-3 levels were found to be similar in all three patient groups. When these biomarkers and functional test scores were compared, moderate correlation between serum COMP level and VAS score, moderately negative correlation with WOMAC, and low-moderately negative correlation with KOOS-PS was found. There was no correlation between serum MMP-3 level and VAS, WOMAC, KOOS-PS scores, but a low correlation with Lequesne score was observed. Conclusion: In our study, there was no significant differences in serum COMP and MMP-3 levels between different stage of knee osteoarthritis groups. Further studies are needed in larger sample groups of these biomarkers to predict the diagnosis and prognosis of osteoartritis.