Sıçanlarda Maternal Diyetle Fruktoz Alımının Fetüse Etkilerinin Bazı Lipit Parametreleri ve Lipogenez Açısından İncelenmesi
Özet
The aim of this study was to examine the effects
of high fructose intake during preconception, throughout pregnancy and lactation on some
lipid parameters and insulin level in the plasma, triglyceride accumulation in the liver and
total body fat accumulation of both the mother rats and pups. Therefore, this study was
carried out on Sprague Dawley strain, virgin female rats (n=10). After a two- week wash out
period rats were divided into two groups. The fructose with a concentration of 0.2 g/mL
(20% w/v) in water was administered to the first group and the same amount of
maltodextrin was administered to the other group. After a 12-week dietary manipulation
period the rats were mated for pregnancy. The dietary manipulation continued in the same
way during pregnancy and lactation periods. At the end of lactation period, blood and issues
were isolated from the rats and animals were immediately sacrificed. As a result, it was
found that there were no differences on chow intake while water intake of maltodextrin
group was higher (p=0.016). Body weights, plasma and liver trygliceride levels, plasma free
fatty acids of both mothers and pups were found similar. Plasma insülin levels were
significantly different in the mothers and pups (p=0.049 and p= 0.005, respectively). Total
body fats of mothers in the fructose group were higher (p=0.029) but there was no
difference in total body fats of pups between the two groups. Consequently, it was found
that high fructose intake elevated plasma insülin level and total body fat and high fructose
intake with maternal diet elevated plasma insülin levels. In conclusion, this study showed
that to reduce the risk of chronic diseases such as type II diabetes mellitus and obesity in the
later life of children, fructose intake in preconception, pregnancy and lactation periods might
be restricted.