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Toplam kayıt 48, listelenen: 31-40
Thrombotic Distal Middle Cerebral Artery Occlusion Produced By Topical Fecl3 Application: A Novel Model Suitable For Intravital Microscopy And Thrombolysis Studies
(Nature Publishing Group, 2011)
Intravital or multiphoton microscopy and laser-speckle imaging have become popular because they allow live monitoring of several processes during cerebral ischemia. Available rodent models have limitations for these ...
Deneysel İskemik İnme Modelinde Oksidatif Hasarın Hücresel Düzeyde İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-11)
The aim of this study is direct intravital monitorization of the pharmacological effects of two well-known neuroprotectant antioxidant molecules having different blood-brain barrier (BBB) permeability against ischemia/reperfusion ...
Psikolojik Stres İle Kortikal Yayılan Depresyon Uyarılma Eşiği İlişkisi ve İlgili Mekanizmaları
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2013)
Migraine is suggested to belinked to cortical spreading depression (CSD), thus CSD is used to model migraine inexperimental animals. Migraine is frequently comorbid with depression and anxiety,two disorders that are ...
Fizyolojik Uyarılarla Kortikal Yayılan Depresyonun Oluşturulması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2015)
Migraine is a primary headache disorder with an
annual prevalence of 12-15% in the general population, causing considerable disability
and productivity loss. Migraine aura is associated with cortical spreading depression
(CSD) ...
Hücre Membranı Yamayıcı Molekülleri ile Panneksin1 Megakanalı Arasındaki Olası İlişkinin Araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2015)
For most of the neurological diseases, new theurapeutic targets and drugs are needed. During the last several years one of the large pore channels, Pannexin (Panx) channels have emerged as an important target for neurological ...
Glikojen Döngüsünün Bozulmasının Kortikal Yayılan Depolarizasyon Oluşumu ve Panneksin 1 Kanalları Üzerine Etkisinin Araştırılması
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2013)
Migraine is an episodic neurological disorder that affects 10-20 % of general population. Cortical spreading depression (CSD) is proposed as the mechanism of migraine aura and the downstream trigeminal activation as the ...
Parenchymal Neuroinflammation in Familial Hemiplegic Migraine Type 1 Transgenic Mouse Model After Cortical Spreading Depression
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-01)
Cortical spreading depression (CSD) is the likely cause of the migraine aura. CSD causes a signaling pathway between stressed neurons and trigeminal afferents via transient opening of neuronal Pannexin-1 (Panx1) mega-channels ...
Dysregulated Fibroblast Growth Factor (Fgf) Signaling in Neurological and Psychiatric Disorders
(Academic Press Ltd Elsevier Science Ltd, 2016)
The role of the fibroblast growth factor (FGF) system in brain-related disorders has received considerable attention in recent years. To understand the role of this system in neurological and psychiatric disorders, it is ...
DOPA Yanıtlı Distoni Fare Modelinde Striatal Kolinerjik Sistemin Rolü
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022-05-26)
Dystonia, which is the third most common movement disorder, is a heterogeneous group of diseases both etiologically and pathophysiologically. Striatal cholinergic dysfunction is a common pathophysiologiccal mechanism ...
Optogenetik uyarımla nf-κb aktivasyonu yapan bir yöntemin mss'de inflamasyonun primer depresyon patofizyolojisindeki rolünün incelenmesi amacıyla ın vıvo koşullar için geliştirilmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2023-01-05)
One of the critical limitations of the studies examining the effects of neuro-inflammation on depression is not implementing a protocol compatible with the pathophysiology of primary depression instead of using a protocol ...