Mitomycin C Release from Molecularly Imprinted Microcryogels

Abstract

Molecularly imprinted polymers (MIPs) offer the self-organization of functional monomer/s around target molecules, leading formation of area for the target molecules with the high selectivity. Here, microscale cryogels as injectable forms of [poly (hydroxyethyl methacrylate)] p(HEMA) was developed as novel drug delivery materials using molecular imprinting technology for control the released of Mitomycin C (MMC) as an anti-cancer drug. The MMC imprinted microcryogels were prepared using a micro stencil array chip with microwells of 200 μm diameter and 500 μm thickness and then characterized by Scanning electron microscope (SEM) and swelling degree properties. Furthermore, the non-imprinted microcryogels were prepared to show the imprinted effect of the drug released performance of MMC. The findings showed that the drug imprinted microcryogels could be cost-friendly, and injectable for control release of anti-cancer drugs.