ANCA-İLİŞKİLİ VASKÜLİTLER HASTA KAYNAKLI ÖLÇÜTLER (AAV-PRO) ÖLÇEĞİNİN TÜRKÇE ÇEVİRİSİNİN GÜVENİLİRLİK VE GEÇERLİLİĞİNİN İNCELENMESİ

Abstract

ANCA-associated vasculitides (AAV) are chronic diseases primarily affecting small vessels. This 29-item scale, developed under the leadership of Oxford University in 2016, aims to provide a more objective measurement of conditions alongside disease activity in the treatment and follow-up of patients. This study aimed to evaluate the validity and reliability of the Turkish translation of the AAV-Patient Reported Outcomes (AAV-PRO) scale. Confirmatory factor analysis, hypothesis testing, convergent validity, internal consistency, and intraclass correlation coefficients were calculated based on the original structure of the scale and its validated Italian version. A total of 154 patients with AAV, who applied to Hacettepe, Gazi, and İzmir Katip Çelebi University and agreed to participate between January 2023 and May 2024, were included in the study. The mean (SD) age was 52.6 (14.8) years, and 45.5% were female. Of all patients, 111 (72.1%) patients had GPA, and 24 (15.6%) had EGPA; the distribution of organ involvement was similar to the literature. Construct validity was not achieved for the original scale structure. However, in the confirmatory factor analysis of the Italian scale structure (3 subgroups), CMID/DF was 1.36, IFI=0.95, TLI=0.95, CFI=0.95, and RMSA=0.048 in the study group, indicating that the scale’s construct validity was achieved. Subscores in active patients (hypothesis-test validity) were significantly higher. A strong correlation was found between the subgroup scores and EQ-5D-5L subgroup scores (convergent validity). The Cronbach’s alpha coefficient was 0.94. Forty-six patients were included in the test-retest analysis. Intraclass correlation coefficients were calculated as 0.95 [95% Confidence Interval (CI) = 0.90–0.97] for the ‘organ-specific and systemic symptoms’ subgroup, 0.94 (0.90–0.97) for ‘physical function’, and 0.96 (0.92–0.98) for the ‘social and emotional impact’ subgroup. The Turkish translation of the AAV-PRO scale (in the 3-subgroup structure) has been demonstrated to be a valid and reliable tool for the follow-up and treatment of patients with AAV.