Üst Üriner Sistem Ürotelyal Kanseri Nedeniyle Cerrahi Yapılan Hastalarda Prognoz ve Sağkalım Üzerine Etkili Faktörlerin Araştırılması

Abstract

Balayev T. Investigation of Prognostic Factors on Prognosis and Survival in Patients Undergoing Surgery for Upper Urinary Tract Urothelial Carcinoma: A Retrospective Analysis" University of Hacettepe School of Medicine, Thesis in Urology, Ankara 2023. Between 1987 and 2023, data from 210 patients who underwent surgery due to upper urinary tract urothelial carcinoma (UTUC) without metastasis at the time of diagnosis and a history of muscle-invasive bladder cancer (MIBC) were retrospectively analyzed. Factors influencing bladder recurrence and survival were investigated. The data were analyzed using SPSS 23.0 software. The median followup period was 24 (1-324) months, and the mean age at surgery was 62,5 ± 11 years. Of the patients, 91 (43.3%) were <62.5 years old, and 119 (56.7%) were >62.5 years old, with a female-to-male ratio of 44/166. Bladder tumor history, high tumor grade, and positive surgical margin (PSM) were found to be independent risk factors for cancer-specific survival (p=0.034, p=0.019, p<0.001; respectively). High T stage and grade, PSM were significant risk factors for cancer-specific survival. Advanced hydronephrosis, age, and surgical margin status were identified as factors affecting overall survival (respectively, p=0.048, p=0.003, p=0.003, p<0.001). Patients with tumor at the surgical margin, a history of MIBC, or high-grade tumor should be closely monitored for postoperative bladder recurrences. Keywords: Upper urinary tract, urothelial carcinoma, survival