Metilentetrahidrofolat Redüktaz Gen Olimorfizmi Olan Gebe Kadınlarda Antenatal Depresyon ve Bazı Aminoasitlerle İlişkisi
Abstract
Methylenetetrahydrofolate Reductase (MTHFR) is the enzyme converting
5,10-methylenetetrahydrofolate (product of cytosolic serine hydroxymethyltransferase) to 5-
methyltetrahydrofolate for homocysteine remethylation. MTHFR gene polymorphism is
one of the congenital disorders related with homocysteine metabolism. Both
hyperhomocysteinemia’s possible negative effect on woman and fetal health, and
homocysteine’s role in depression etiology makes woman prone to antenatal
depression. This research is planned for determining amount of nutrients, mainly
aminoacids, consumed by pregnant and non-pregnent women with or without
MTHFR gene polymorphism, for determining plasma vitamin B12, folate, iron,
thyroid stimulating hormone concentrations in maternal venous (14th, 24th, 32nd
gestational weeks, at birth) and umblical cord blood and determining apgar scores
and the relationship between these parametres and effect of these parametres on
antenatal depression. Therefore, we determined that half of the subjects at all subpolymorphism
groups had Beck Depression Inventory (BDI) scores convenient for
taking depression diagnosis, and one third of the subjects at all sub-polymorphism
groups had mild or midgrade anxiety. MTHFR gene polymorhism was statistically
related to live birth number (p=0.000, <0.05), number of abortus at 10th and 22nd
gestation weeks (p=0.008, < 0.05), birth weight (p=0.003, p<0.05), total pregnancy
number (p=0.003, <0.05), and first pregnancy history (p=0.000, <0.05). Umblical
cord blood folic acid and vitamin B12 values were statistically related to 14th
gestation week iron consumption (p=0,013, <0,05) and 24th gestation week folic acid
consumption (p=0,008, <0,05). Postnatal first and fifth minute apgar score was
statistically related to and 32nd gestation weeks (p<0,05). Socia support taking
situation of pregnant women with MTHFR gene polymorphism was statistically
related to BDI scores (p=0.006, <0.05). In conclusion, maternal nutrition can effect
newborn’s Apgar score and blood parametres.