Piperasilin-Tazobaktam ve Vankomisin Antibiyoterapilerinin Birlikte Kullanımının Nefrotoksik Etkilerinin Incelenmesi

Abstract

Aim of the Study: To assess the risk of acute kidney injury related to the use of piperacillintazobactamcombined with vancomycin, which is an effective regimen for treatment of healthcare associated infections.Materials and Methods: The hospital charts of 402 patients who received piperacillintazobactamalone, vancomycin alone, piperacillin-tazobactam combined with vancomycin,and meropenem combined with vancomycin was evaluated retrospectively in a two-yearperiod from January 1st, 2012 to December 31st, 2013. The patients admitted to the intensivecare units, those with a baseline serum creatinine level higher than 2 mg dL, the patients inhemodialysis or peritoneal dialysis program, pregnant women and, finally, those in septicshock were not included. The presence and severity of acute kidney injury was assessedaccording to the AKIN criteria. The possible factors determined in univariate analysis weretested with logistic regression analysis to find out if they were i