Tüp Mide Ameliyatı Geçiren Bireylerde Beslenme Durumu, Serum Nesfatin Düzeyi ve Glikoz Regülasyonunun İncelenmesi

Abstract

Nesfatin-1 was discovered in 2006 by Oh-I et al. and it is thought to be an anorectic protein with significant effects on glucose regulation. The aim of this study was to determine the nutritional status and serum nesfatin levels of individuals undergoing sleeve gastrectomy and to investigate the relationship between serum nesfatin and glucose levels. Fourty volunteers (31 females, 9 males) aged between 19 and 64 years with a body mass index greater than 30, without type 2 diabetes, who underwent sleeve gastrectomy participated in the study. In order to determine general demographic characteristics, and nutritional habits and status, a questionnaire was administered to individuals before operation and one month after operation. Anthropometric measurements (height, body weight, waist and hip circumference, neck circumference, body mass index, basal metabolic rate, body fat percentage), 24-hour recall food consumption records and blood samples were collected from the subjects before and one month after the operation. In the first postoperative month, body weight, body mass index and body fat ratio values significantly decreased (p<0.001). Postoperative serum nesfatin-1 levels (74.6±40.11 pg/ml) were decreased compared to preoperative serum nesfatin-1 levels (108.3±58.34 pg/ml) (p<0.05). There was no correlation between serum nesfatin-1 levels and anthropometric measurements (p>0.05). There was no correlation between serum nesfatin-1 levels and fasting blood glucose and plasma insulin levels (p>0.05). In our study, it was found that nesfatin levels decreased after postoperative weight loss, but no correlation was found between nesfatin level and glucose and insulin levels one month after surgery. More and longer term researches are needed to clarify the relationship between serum nesfatin levels and glucose regulation on individuals who underwent bariatric surgery.