Silikon Hidrojel Kontakt Lenslerin Göz Yüzeyi Üzerine Olan Etkilerinin İncelenmesi

Abstract

The Effects of Silicon Hydrogel Contact Lenses on the Ocular Surface, Hacettepe University School of Medicine, Department of Ophthalmology, Thesis in Ophthalmology, Ankara, 2015. The aim of this study is to compare the tear cytokine levels of silicon hydrogel contact lens users with the healthy controls and to evaluate the relationship with ocular surface inflammation caused by the contact lens usage and meibomian gland dysfunction. In this study we investigated tear function tests; tear break-up time, ocular surface staining, Schirmer test, OSDI (Ocular Surface Disease Index) questionaire and tear IL-1RA, IL-1β, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17, IFN-α, IFN-γ, TNF-α, GM-CSF, IP-10, MIG, RANTES, Eotaxin, MIP-1α, MIP-1β, MCP-1 levels with luminex in 20 patients who have used silicone hydrogel contact lenses for at least 6 months coexisting meibomian gland dysfunction (group 1), 20 patients who have used for at least 6 months silicone hydrogel contact lenses without meibomian gland dysfunction (group 2), 20 patients who had meibomian gland dysfunction and who were not using contact lenses (group 3) and 20 healthy individuals without any known systemic and ocular diseases and who were not using contact lenses (group 4). In group 1 tear break-up time was lower (p=0.048); ocular surface staining (p=0.032) and OSDI scores (p=0.001) were higher than the control group but tear cytokine levels were similar in all groups. Our results suggest that, meibomian gland dysfunction is not associated with a clinically significant ocular surface inflammation in contact lens users.