Selektif Transarteryal Mikrokateterizasyon Yöntemi ile Parçalanabilir Nişasta Mikrokürecikleri Kulanılarak Geçici Serebral İskemi Modeli Oluşturularak İntrakarotid Sodyum Tiyopental Uygulamasının Geçici İskemi Süresine Etkisinin Araştırılması

Abstract

Degradable starch microspheres combined with chemotherapeutic agents applied into vascular structures by selective trans-arterial microcatheterization method to achieve locoregional tumor treatment is frequently performed. The aim of these clinical practices is to impair tumor blood supply, reduce the side effects and systemic toxicity and acquire higher drug concentrations in target organ. There are many studies research brain tolerance to ischemia. Stroke is defined by the World Health Organization7 as ‘a clinical syndrome consisting of rapidly developing clinical signs of focal (or global in case of coma) disturbance of cerebral function lasting more than 24 hours or leading to death with no apparent cause other than a vascular origin. Ischemic stroke consists of 80-85% of cerebrovasculer diseases and is most frequent disease that causes death. Because of these results many experimental stroke models have been developed for understanding the stroke’s exact mechanism. Penumbra is shown to be more tolerable for ischemia or easy to survive in ischemic conditions. There were not enough studies about the brain which is considered to be very sensitive because a short period of ischemic condition can cause permanent neurological deficits. In this study; cerebral ischemia was created by the introduction of degradable starch microspheres via selective trans-arterial microcatheterization. Thiopental effects on ischemia are published in many papers in recent years. Thiopental has many side effects and hard to control its effects because it has very narrow clinical usage. In this study we achieved cerebral supression by low dose intraarterial thiopental and by using lower doses avoided the side effects of thiopental. If intracarotid thiopental achieves on cerebral ischemia it can be used with tromboliytic agents on acute stroke patients. Thiopental can elong the ischemia time and as a result it can lower the mortality and morbidity.