Uyku Hastalıklarında Gelişebilecek Otonomik Değişikliklerin Kalp Hızı Değişkenliği ile Tespiti
Date
2018Author
Aslan, Sabina
Aslan, Sabina
xmlui.mirage2.itemSummaryView.MetaData
Show full item recordAbstract
It is known that sleep disorders are associated with cardiovascular and
cerebrovascular morbidity and mortality. The role of the autonomic system
dysfunctions in this is discussed. The aim of our study was to evaluate heart rate
variability (HRV), which is a marker of autonomic function, in sleep disorders
frequently encountered sleep disorders, such as narcolepsy and REM Behavioural
Disorders (RBD) in neurology sleep outpatient clinics and to compare, that with
healthy controls. 26 patients who were diagnosed with narcolepsy according to
ICSD 3 and 10 patients who matched the RBD criteria were included in this study
from the patients who were admitted to Hacettepe University Neurology
Department Polisomnography (PSG) laboratory. PSG findings of patients and ECG
data of PSG recordings were examined. HRV analysis of all patients by means of
time and frequency dependent automatic analysis; in different sleep stages and
multiple sleep latency tests (MSLT) were calculated. LF and LF / HF values increased
in NREM Stage 2 in narcolepsy patients(p=0.025; p=0.008). The lower RMSSD value
during REM sleep stage in narcoleptic patients with cataplexy than without
cataplexy was remarkable (p=0.041). In SOREM (-) the SDNN score was significantly
lower (p=0.018) in comparison with SOREM (+). SDNN values in REM was found to
be decreased in RBD patients compared to control group (p=0.004) . As a result, it
has been observed that HRV was decreased in REM, especially in narcoleptic
patients with cataplexy. As supporting findings of previous few studies in the
literature, it has been shown that HRV is decreased during REM in RBD patients.
Also the abnormalities in HRV were less pronounced in narcoleptic patients having
sleep onset REM during their raps than who did not have. These our HRV findings
which can show the possible risks of morbidity and mortality in narcolepsy and RBD
patients who have cardiac autonomic dysfunction during sleep, would be important
in preventive medicine if these will be supported by further long-term prospective
studies