Ülseratif Kolit Hastalarında Standart Tedaviye Sinbiyotik Eklenmesinin Hastalık aktivitesi ile İlgili Parametrelere ve Yaşam Kalitesine Etkisi

Abstract

Ulcerative colitis (UC) is a disease affecting the quality of life, workforce and nutrition of patients negatively due to its symptoms. This study was conducted for the purpose of evaluating the effect of the synbiotic treatment initiated as an addition to the standard treatment in UC patients with a mild-moderate disease activity on the quality of life with acute phase reactants, clinical and endoscopic activity. In this placebo-controlled, randomized, single-blind study, 40 UC patients complying with the inclusion criteria were included and 36 patients completed the study. The intervention group (n=18) used a synbiotic supplement for 8 weeks, and the control group (n=18) used a placebo. Individuals’ food consumption frequencies, dietary records and anthropometric measurements (height and body weight) were taken and the quality of life scale was completed at the beginning and end of the study to assess the effect of the disease on the quality of life. Clinical and endoscopic activities of the disease were evaluated with the help of indices. While no differences were observed in the energy and nutrient intakes of the individuals in the control group at the beginning and end of the study, a significant increase was observed in the vitamin B1, B2, B6, potassium and phosphorus intakes of only males in the intervention group at the end of the study when compared to the beginning of the study (p<0,05). It was determined that the serum CRP and sedimentation values of the individuals in the intervention group were significantly lower at the end of the study (p<0,05). A statistically significant improvement was observed in the disease clinical and endoscopic activity levels of the individuals both in the control and intervention groups (p<0,05). It was determined that the decrease in the endoscopic activity score was more in the intervention group. At the end of the study, it was determined that more patients entered remission in the intervention group (10/18). It was observed that the patients in the intervention group had higher quality of life scores in comparison with those in the control group. At the end of the study, it was seen that the use of synbiotics in UC patients significantly reduced acute phase reactants, clinical and endoscopic activity levels and improved the patients’ quality of life.