Eczacılık Fakültesi
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Fruktozla indüklenen hipertansif sıçan modelinde nöroinflamasyon ve artmış kan basıncı üzerine mikroglial inhibisyonun etkisi.
(Sağlık Bilimleri Enstitüsü, 2024)Neuroinflammation and increased sympathetic activity are at the forefront of the neurogenic etiology of hypertension. Microglia, the structural immune cells of the brain, plays a critical role in the inflammatory process ... -
İDİYOPATİK PULMONER FİBROZİS (İPF) TEDAVİSİNDE KULLANILMAK ÜZERE NİNTEDANİB VE miR-29b YÜKLÜ LİPOPLEKS FORMÜLASYONLARININ GELİŞTİRİLMESİ, KARAKTERİZE EDİLMESİ VE TEDAVİ ETKİNLİKLERİNİN İPF HÜCRE KÜLTÜRÜ MODELİNDE DEĞERLENDİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2024-08-16)Idiopathic pulmonary fibrosis (IPF) is a disease with a high mortality rate, caused by cellular stress and tissue damage in the lungs, leading to the excessive accumulation of extracellular matrix (ECM) components that ... -
METİSİLİNE DİRENÇLİ STAPHYLOCOCCUS AUREUS (MRSA) KAYNAKLI DERİ ENFEKSİYONLARIN TEDAVİSİ İÇİN TOPİKAL BİYOADEZİF JEL FORMÜLASYONLARININ GELİŞTİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2024)In this study, it was aimed to develop a drug delivery system that will be applied topically in the treatment of skin infections caused by Methicillin-resistant S. aureus (MRSA), which has caused frequent infections in the ... -
Herpes Simpleks Enfeksiyonunun Topikal Yolla Tedavisine Yönelik Asiklovir Yüklü Kitosan/Poliakrilik Asit Film Formülasyonları Hazırlanması ve İn Vitro Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2024)Herpes simplex virus is a very common disease with 2 types as HSV-1 and HSV -2, approximately 90% of which are known to be prevalent until 40 years of age. The infection can be transmitted through body fluids or direct ... -
MYRTUS COMMUNIS L. ÜZERİNE FARMASÖTİK BOTANİK ARAŞTIRMALAR
(Sağlık Bilimleri Enstitüsü, 2024-09-23)Myrtus communis L., a member of the Myrtaceae family, is a naturally growing, evergreen plant in our country. It is used internally in stress management, diabetes treatment, wound healing, cholesterol lowering, diarrhea ... -
OTOMOTİV SANAYİSİ ÇALIŞANLARINDA OLASI GENOTOKSİK HASARIN DEĞERLENDİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2024-08-31)A lot of people have been employed in the automotive production sector worldwide and our country. Automotive production consists of many steps, at which there are different levels of exposure to welding fumes, paint, ... -
Linaria corifolia Desf. Üzerinde Farmakognozik Araştırmalar
(Sağlık Bilimleri Enstitüsü, 2024-09-16)Linaria Mill. genus that is a member of the Plantaginaceae family is widely found in our country. There are approximately 200 species of Linaria in the world, 21 in Turkey, and 12 of them are endemic. Linaria species, ... -
ANTİMİKROBİYAL TEDAVİDE İNTRAVENÖZDEN ORALE GEÇİŞ PROTOKOLÜ GELİŞTİRİLMESİ VE UYGULAMASININ GEÇİŞE ETKİSİ VE KLİNİK ECZACININ ROLÜ
(Sağlık Bilimleri Enstitüsü, 2024)In antimicrobial treatment, it is recommended to switch from intravenous to oral therapy in eligible patients to reduce complications and ensure pharmacoeconomic treatment. In this study, we evaluated the effect of a ... -
DOĞAL VE SENTETİK ENDOKRİN BOZUCU KİMYASAL MADDELERİN 3T3- L1 HÜCRELERİNDE ADİPOJENEZLE İLGİLİ PROTEİNLER ÜZERİNDEKİ TOKSİK ETKİLERİNİN KARŞILAŞTIRMALI OLARAK DEĞERLENDİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2024)Bilinmiş, İ. Comparative Evaluation of the Toxic Effects of Natural and Synthetic Endocrine Disrupting Chemicals on Adipogenesis-Related Proteins in 3T3-L1 Cells, Hacettepe University Graduate School of Health Sciences ... -
In Silico Toksikoloji Yöntemleri ve Uygulamaları Üzerine Araştırmalar
(Sağlık Bilimleri Enstitüsü, 2024)The use of computer-assisted toxicology methods (in silico toxicology, computer-based toxicology etc.) in predicting preclinical toxicological endpoints, clinical side effects, and the metabolism of pharmaceutical ... -
STATİNLERİN ABSORPSİYON VE PERMEABİLİTELERİ ÜZERİNE GREYFURT SUYUNUN ETKİSİNİN İNCELENMESİ
(Sağlık Bilimleri Enstitüsü, 2024)The aim of this study is to examine the intestinal absorption of four model substances (atorvastatin, pravastatin, simvastatin, lovastatin) selected from the statins, using both the Caco-2 cell line and the in situ intestinal ... -
Glioblastom Tedavisinde İleri Yaklaşım: Tümör Mikroçevresine Duyarlı ve Dual Etkili Nanopartiküler Sistemlerin Radyoterapinin Etkinliğini Artırmak İçin Tasarlanması ve Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2024)Glioblastoma is one of the most aggressive brain tumors due to its features such as rapid proliferation and high invasion. Within the scope of this thesis study, in order to provide effective treatment of GBM by using ... -
Endokannabinoid Metabolizmasının İnhibisyonunun Alerjik Solunum Yolu İnflamasyonunda Yeni Bir Tedavi Stratejisi Olarak İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2024-07-10)Endocannabinoids are biologically active endogeneous substances with a cannabinoid structure. Their degradation is primarily carried out by two enzymes: fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). ... -
Meme Kanseri (Mcf-7) Hücre Haattında Lc/Ms Temelli Metabolomik ve Lipidomik Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2024-07-04)In this thesis, the effects of five different drug carrier nanoparticles, both loaded and unloaded with paclitaxel, on MCF-7 cancer cell lines were investigated using liquid chromatography-mass spectrometry (LC/MS)-based ... -
Romatoloji Kliniğinde Takip Edilen Hastalarda Glukokortikoid Tedavisinin İzlemi
(Sağlık Bilimleri Enstitüsü, 2024)Glucocorticoid toxicity index (GTI) is an assessment tool that measures glucocorticoid-related toxicity and its change over time. This study aimed to assess the glucocorticoid therapy of patients in a rheumatology outpatient ... -
Ultrafiltrasyon Tekniği Kullanılarak Ketoprofen’in İnsan Plazmasından Yüksek Performanslı Sıvı Kromatografisi ile Tayini İçin Analitik Yöntem Geliştirilmesi ve Validasyonu
(Sağlık Bilimleri Enstitüsü, 2024)ABSTRACT Demir, A. Analytical Method Development and Validation for Determination of Ketoprofen from Human Plasma by High Performance Liquid Chromatography Using the Ultrafiltration Technique, Hacettepe University Graduate ... -
Overektomi Uygulanan Sıçanların Detrusor Düz Kasında Hücre İçi Kalsiyum Hareketleri Üzerinde Hidrojen Sülfürün Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2024)Women experience incontinence during menopause, as a result of the decrease in estrogen levels due to aging. Hydrogen sulfide is an endogenous gasotransmitter which has relaxant effect on detrusor smooth muscle and estrogen ... -
Sıçanlarda Subakut Alkol Kullanımına Bağlı Gelişen Karaciğer Fibrozisinde İdebenon ve Koenzim Q10’un Etkisinin NLRP3 İnflamazom Aktivitesi Üzerinden İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2024-06-13)YOLADI, F.B., Investigation of the Effects of Idebenone and Coenzyme Q10 on Liver Fibrosis Due to Subacute Alcohol Use in Rats through NLRP3 Inflammasome Activity, Hacettepe University Graduate School of Health Sciences, ... -
Gentiana olivieri Griseb.’in Nöroprotektif Etkisi
(Sağlık Bilimleri Enstitüsü, 2024-06-25)The genus Gentiana has 400 species in the world and 12 species in Türkiye, and plants belonging to this genus have had a wide range of uses in folk medicine for many years. Gentiana olivieri Griseb. used in Southeastern ... -
Sıçan İzole Torasik Aortunda Perivasküler Adipoz Doku Fonksiyonundaki Yaşa Bağlı Değişimin In Vıtro ve In Vıvo Çalışmalarla Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2024)Perivascular adipose tissue (PVAT) is the layer of fat surrounding the outside of blood vessels and contributes to the control of vascular tone through the release of relaxing factors that exhibit anticontractile effects ...
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