Diyete Eklenen Farklı Türlerdeki Şekerin Yağ Asit Translokasyonu, Depolanması Ve İştah İle İlintili Peptidler Üzerine Etkileri

Abstract

This study was done to examine the effects of high consumption of added sugar (sucrose, fructose, high fructose corn syrup) on dams and pups when consumed as a part of the maternal diet through the points of obesity, fatty acid translocation and accumulation, appetite peptides, and insulin resistance. The blood and tissues used in this study was provided from Sprague Dawley rats (n=29) and their pups (n=196). After a wash-out period rats were divided into five groups. Added sugars (sucrose, fructose or high fructose corn syrup-HFCS) were added in the drinking water of rats at a concentration of 20%w/v, the same amount of maltodextrin was added to the drinking water of the vehicle and plain water was administered to the control group. The same diets were continued before, during gestation and lactation at a total of 18 weeks. The analysis results of the dietary manipulation groups were compared with the control group. Feed intake was high in the HFCS and sucrose groups whereas drink intake was high only in the HFCS group (p<0,05). Maternal added sugar intake increased body weights of dams whereas maternal HFCS and fructose intake increased body weights of pups (p<0,05). Plasma leptin was decreased in the fructose group of dams whereas decreased in the HFCS and fructose group of pups (p<0,05). Plasma ghrelin was increased both in dams and pups in the group of HFCS (p<0,05). Maternal added sugar intake increased the body fat, plasma glucose, plasma insulin and HOMA-IR index values of both dams and pups (p<0,05). Maternal HFCS intake increased sCD36 in both dams and pups whereas maternal fructose intake only increased sCD36 in dams (p<0,05). The expression of phosphorylated Acetyl CoA Carboxylase in the liver was the highest in the HFCS group of dams and in the fructose group of pups. The results of this study shows that added sugar consumption during pre-gestation, gestation and lactation may lead to obesity and other related disorders through the appetite and lipogenesis mechanisms in both dams and pups.