KOROİD PLEKSUS, BEYİN HACİMLERİ ve NÖROFİLAMAN HAFİF ZİNCİR DÜZEYLERİNİN RADYOLOJİK İZOLE SENDROM, MULTİPL SKLEROZ ve SAĞLIKLI KONTROLLERLE KARŞILAŞTIRMALI ANALİZİ

Abstract

Multiple sclerosis (MS) is neuroinflamating and neurodegenerative disease of central nervous system. Radiologically Isolated Syndrome (RIS) describes patients with incidental demyelinating white matter lesions. Currently, RIS is accepted as a part of MS continuum. Choroid plexus volume is a newly emerging radiological marker in various neurological diseases. In this study, it was aimed to evaluate the value of choroid plexus volume as a biomarker and its relation to serum NFL levels and regional brain volumetrics. 16 RIS, 48 (34 Mild and 14 Severe) relapsing remitting MS (RRMS) and 16 healthy controls were included. Baseline and first-year follow-up imaging and serum samples were collected. Choroid plexus and regional brain volume was extracted. Choroid plexus was larger in RIS and MS groups than healthy controls (p=0,002). Groups also differed in volumes of white matter, corpus callosum, lateral ventricle, thalamus, caudate, putamen, pallidum and hippocampus. Choroid plexus volume was correlated with age, IgG index, lesion volume and the volume of lateral ventricles. A negative relationship was found between choroid plexus and thalamus, putamen and hippocampal volumes. Serum NFL levels were inversely correlated with white matter, thalamus and putamen volumes while positively correlated with lesion volume. No relationship was found between serum NFL levels and choroid plexus volume. Choroid plexus volume predicts thalamus atrophy in multiple lineer regression model (=-0,159, p=0,035). Regional brain volumes and NFL levels were stable in one-year follow-up. Choroid plexus volume can be used as a biomarker in MS continuum for prognostic purposes.